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Spag6 Gene Detail
Summary
  • Symbol
    Spag6
  • Name
    sperm associated antigen 6
  • Synonyms
    BC061194, Spag6l
  • Feature Type
    protein coding gene
  • IDs
    MGI:3040687
    NCBI Gene: 381350
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:18698808-18754561 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 12.90 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1367 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3040687
 protein coding gene Chr2:18698808-18755224 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025377
 protein coding gene Chr2:16410326-16470177 (+)
A/J MGP_AJ_G0025355
 protein coding gene Chr2:15748526-15804224 (+)
AKR/J MGP_AKRJ_G0025323
 protein coding gene Chr2:16266980-16324559 (+)
BALB/cJ MGP_BALBcJ_G0025350
 protein coding gene Chr2:15770797-15827668 (+)
C3H/HeJ MGP_C3HHeJ_G0025110
 protein coding gene Chr2:16194789-16254979 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025793
 protein coding gene Chr2:16828064-16889743 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023208
 protein coding gene Chr2:15136833-15193563 (+)
CAST/EiJ MGP_CASTEiJ_G0024574
 protein coding gene Chr2:16163800-16220056 (+)
CBA/J MGP_CBAJ_G0025089
 protein coding gene Chr2:17588590-17654223 (+)
DBA/2J MGP_DBA2J_G0025221
 protein coding gene Chr2:15673201-15730211 (+)
FVB/NJ MGP_FVBNJ_G0025184
 protein coding gene Chr2:15469272-15525317 (+)
LP/J MGP_LPJ_G0025308
 protein coding gene Chr2:16245979-16305514 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025215
 protein coding gene Chr2:17544243-17607420 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025851
 protein coding gene Chr2:16220698-16280383 (+)
PWK/PhJ MGP_PWKPhJ_G0024323
 protein coding gene Chr2:15549385-15605150 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024123
 protein coding gene Chr2:16356316-16413404 (+)
WSB/EiJ MGP_WSBEiJ_G0024644
 protein coding gene Chr2:16280838-16342586 (+)



Homology
more
  • Human Ortholog
    SPAG6, sperm associated antigen 6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SPAG6, sperm associated antigen 6
  • Synonyms
    CFAP194, CT141, FAP194, pf16, Repro-SA-1
  • Links
    NCBI Gene ID: 9576
    UniProt: O75602

  • Chr Location
    10p12.2; chr10:22345445-22454224 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Homozygous null mice are grossly normal, with normal fertility and sperm parameters, and normal behavior.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    8
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 381350 NCBI Gene Model | MGI Sequence Detail 55754 C57BL/6J ±  kb
transcript NM_001409584 RefSeq | MGI Sequence Detail 2732 C57BL/6  
polypeptide NP_001396513 RefSeq | MGI Sequence Detail 509 C57BL/6  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 8
    cDNA 8

    Microarray probesets 2
Other
Accession IDs
less
MGI:3757726
References
more
  • Summaries
    All 32
    Gene Ontology 2
    Phenotypes 8
  • Earliest
    J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
07/22/2025
MGI 6.24 		The Jackson Laboratory