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Zbtb24 Gene Detail
Summary
  • Symbol
    Zbtb24
  • Name
    zinc finger and BTB domain containing 24
  • Synonyms
    ZNF450
  • Feature Type
    protein coding gene
  • IDs
    MGI:3039618
    NCBI Gene: 268294
Location & Maps
more
  • Sequence Map
    Chr10:41450396-41465571 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      15176 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 22.38 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    ZBTB24, zinc finger and BTB domain containing 24
  • Vertebrate Orthologs
    11
  • Human Ortholog
    ZBTB24, zinc finger and BTB domain containing 24
    Orthology source: HomoloGene
  • Synonyms
    BIF1, ICF2, PATZ2, ZNF450
  • Links
    NCBI Gene ID: 9841
    neXtProt AC: NX_O43167

  • Chr Location
    6q21; chr6:109462516-109483237 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 8870
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;2 zebrafish
  • HCOP
    human homology predictions: ZBTB24
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human ZBTB24 associations

Human Disease Mouse Models
       Immunodeficiency-Centromeric Instability-Facial Anomalies Syndrome 2; ICF2   OMIM: 614069
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    13
  • Chemically induced (other)
    1
  • Gene trapped
    8
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Zbtb24
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000019826 Ensembl Gene Model | MGI Sequence Detail 15176 C57BL/6J ±  kb
transcript ENSMUST00000080771 Ensembl | MGI Sequence Detail 2828 Not Applicable  
polypeptide ENSMUSP00000079592 Ensembl | MGI Sequence Detail 710 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    100 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000017570 zinc finger and BTB domain-containing protein 24
  • InterPro Domains
    IPR000210 BTB/POZ domain
    IPR011333 SKP1/BTB/POZ domain
    IPR007087 Zinc finger, C2H2
    IPR015880 Zinc finger, C2H2-like
    IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Molecular
Reagents
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  • All nucleic 12
    cDNA 11
    Primer pair 1

    Microarray probesets 6
References
more
  • Summaries
    All 27
    Developmental Gene Expression 4
    Gene Ontology 4
    Phenotypes 13
  • Earliest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
  • Latest
    J:202604 Nagamachi A, et al., Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7. Cancer Cell. 2013 Sep 9;24(3):305-17

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory