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Znrf3 Gene Detail
Summary
  • Symbol
    Znrf3
  • Name
    zinc and ring finger 3
  • Synonyms
    LOC382477
  • Feature Type
    protein coding gene
  • IDs
    MGI:3039616
    NCBI Gene: 407821
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr11:5276324-5444847 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      168524 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 3.46 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    ZNRF3, zinc and ring finger 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ZNRF3, zinc and ring finger 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BK747E2.3, RNF203
  • Links
    NCBI Gene ID: 84133
    neXtProt AC: NX_Q9ULT6
    UniProt: Q9ULT6

  • Chr Location
    22q12.1; chr22:28800657-29057488 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    4 phenotypes from multigenic genotypes
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted allele exhibit complete lethality around birth, aphakia, abnormal lens development and defective enural tube closure in some mice.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    18
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    17
  • Tissues
    11
  • cDNA Data
    21
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000005083 VEGA Gene Model | MGI Sequence Detail 168524 C57BL/6J ±  kb
    transcript OTTMUST00000011371 VEGA | MGI Sequence Detail 6311 Not Applicable  
    polypeptide OTTMUSP00000005301 VEGA | MGI Sequence Detail 913 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      315 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      cDNA 22

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGI:2686013, MGI:3034979
    References
    more
    • Summaries
      All 32
      Developmental Gene Expression 5
      Gene Ontology 4
      Phenotypes 8
    • Earliest
      J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
    • Latest
      J:236636 Planas-Paz L, et al., The RSPO-LGR4/5-ZNRF3/RNF43 module controls liver zonation and size. Nat Cell Biol. 2016 May;18(5):467-79
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    05/15/2018
    MGI 6.12     		The Jackson Laboratory