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Znrf3 Gene Detail
Summary
  • Symbol
    Znrf3
  • Name
    zinc and ring finger 3
  • Synonyms
    LOC382477
  • Feature Type
    protein coding gene
  • IDs
    MGI:3039616
    NCBI Gene: 407821
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:5226329-5394847 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 3.46 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2479 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3039616
 protein coding gene Chr11:5226324-5394847 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018000
 protein coding gene Chr11:2306579-2484275 (-)
A/J MGP_AJ_G0017973
 protein coding gene Chr11:2237437-2404121 (-)
AKR/J MGP_AKRJ_G0017937
 protein coding gene Chr11:2368708-2537285 (-)
BALB/cJ MGP_BALBcJ_G0017941
 protein coding gene Chr11:2220405-2390546 (-)
C3H/HeJ MGP_C3HHeJ_G0017754
 protein coding gene Chr11:2242521-2412358 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018393
 protein coding gene Chr11:2377291-2555708 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016051
 protein coding gene Chr11:2128646-2296181 (-)
CAST/EiJ MGP_CASTEiJ_G0017316
 protein coding gene Chr11:2201017-2377338 (-)
CBA/J MGP_CBAJ_G0017729
 protein coding gene Chr11:2693805-2879483 (-)
DBA/2J MGP_DBA2J_G0017839
 protein coding gene Chr11:2137243-2304822 (-)
FVB/NJ MGP_FVBNJ_G0017831
 protein coding gene Chr11:2176372-2342156 (-)
LP/J MGP_LPJ_G0017910
 protein coding gene Chr11:2393383-2568224 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017857
 protein coding gene Chr11:2305029-2509989 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018433
 protein coding gene Chr11:2347099-2515886 (-)
PWK/PhJ MGP_PWKPhJ_G0017096
 protein coding gene Chr11:2159429-2328867 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016893
 protein coding gene Chr11:2335859-2505918 (-)
WSB/EiJ MGP_WSBEiJ_G0017370
 protein coding gene Chr11:2208672-2374608 (-)



Homology
more
  • Human Ortholog
    ZNRF3, zinc and ring finger 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZNRF3, zinc and ring finger 3
  • Synonyms
    BK747E2.3, RNF203
  • Links
    NCBI Gene ID: 84133
    UniProt: Q9ULT6

  • Chr Location
    22q12.1; chr22:28883572-29057488 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    4 phenotypes from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted allele exhibit complete lethality around birth, aphakia, abnormal lens development and defective enural tube closure in some mice.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    48
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    737
  • Tissues
    20
  • cDNA Data
    23
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 407821 NCBI Gene Model | MGI Sequence Detail 168519 C57BL/6J ±  kb
    transcript NM_001290501 RefSeq | MGI Sequence Detail 7199 C57BL/6  
    polypeptide Q5SSZ7 UniProt | EBI | MGI Sequence Detail 913 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 25
      cDNA 24
      Primer pair 1

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGI:2686013, MGI:3034979
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 10
      Gene Ontology 13
      Phenotypes 17
    • Earliest
      J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
    • Latest
      J:359861 Kay RGG, et al., Gonadal sex reversal at single-cell resolution in Znrf3-deficient mice. Development. 2024 Dec 1;151(23)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    03/18/2025
    MGI 6.24     		The Jackson Laboratory