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Pigu Gene Detail
Summary
  • Symbol
    Pigu
  • Name
    phosphatidylinositol glycan anchor biosynthesis, class U
  • Synonyms
    5430426F17Rik, Cdc91l1
  • Feature Type
    protein coding gene
  • IDs
    MGI:3039607
    NCBI Gene: 228812
  • Gene Overview
    MyGene.info: PIGU
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:155278243-155357424 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 77.18 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    730 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3039607
protein coding gene Chr2:155278243-155357430 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026732
protein coding gene Chr2:160087795-160171266 (-)
A/J MGP_AJ_G0026698
protein coding gene Chr2:153724006-153805071 (-)
AKR/J MGP_AKRJ_G0026669
protein coding gene Chr2:158184971-158267602 (-)
BALB/cJ MGP_BALBcJ_G0026707
protein coding gene Chr2:154027186-154107731 (-)
C3H/HeJ MGP_C3HHeJ_G0026450
protein coding gene Chr2:158544783-158627325 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027156
protein coding gene Chr2:164779187-164863131 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024526
protein coding gene Chr2:147229485-147309693 (-)
CAST/EiJ MGP_CASTEiJ_G0025911
protein coding gene Chr2:158847281-158931769 (-)
CBA/J MGP_CBAJ_G0026427
protein coding gene Chr2:170777367-170859749 (-)
DBA/2J MGP_DBA2J_G0026564
protein coding gene Chr2:152908069-152989447 (-)
FVB/NJ MGP_FVBNJ_G0026531
protein coding gene Chr2:151289061-151369637 (-)
LP/J MGP_LPJ_G0026669
protein coding gene Chr2:160230833-160312020 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026552
protein coding gene Chr2:174772000-174868543 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027212
protein coding gene Chr2:158073330-158158643 (-)
PWK/PhJ MGP_PWKPhJ_G0025645
protein coding gene Chr2:152407805-152489700 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025448
protein coding gene Chr2:157003476-157084870 (-)
WSB/EiJ MGP_WSBEiJ_G0025981
protein coding gene Chr2:158958753-159038016 (-)



Homology
more
  • Human Ortholog
    PIGU, phosphatidylinositol glycan anchor biosynthesis class U
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PIGU, phosphatidylinositol glycan anchor biosynthesis class U
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CDC91L1, GAB1
  • Links
    NCBI Gene ID: 128869
    neXtProt AC: NX_Q9H490
    UniProt: Q9H490

  • Chr Location
    20q11.22; chr20:34560542-34677285 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 6553
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: PIGU
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 228812 NCBI Gene Model | MGI Sequence Detail 79182 C57BL/6J ±  kb
transcript NM_001004721 RefSeq | MGI Sequence Detail 1621 C57BL/6  
polypeptide Q8K358 UniProt | EBI | MGI Sequence Detail 434 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • InterPro Domains
    IPR009600 GPI transamidase subunit PIG-U
Molecular
Reagents
less
  • All nucleic 32
    cDNA 32

    Microarray probesets 5
Other
Accession IDs
less
MGI:1918597
References
more
  • Summaries
    All 30
    Gene Ontology 5
    Phenotypes 8
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory