Fbxl19 MGI Mouse Gene Detail - MGI:3039600 - F-box and leucine-rich repeat protein 19

Symbol

Fbxl19
Name

F-box and leucine-rich repeat protein 19
Synonyms

Fbl19

Feature Type

protein coding gene
IDs

MGI:3039600
NCBI Gene: 233902
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr7:127744543-127769483 bp, + strand
From Ensembl annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 69.71 cM
Mapping Data

1 experiment

SNPs within 2kb

124 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3039600	protein coding gene	Chr7:127743957-127769483 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0033051	protein coding gene	Chr7:132116211-132142330 (+)
A/J	MGP_AJ_G0033034	protein coding gene	Chr7:128583709-128608354 (+)
AKR/J	MGP_AKRJ_G0032966	protein coding gene	Chr7:131910394-131935132 (+)
BALB/cJ	MGP_BALBcJ_G0033035	protein coding gene	Chr7:128237235-128262886 (+)
C3H/HeJ	MGP_C3HHeJ_G0032749	protein coding gene	Chr7:131807098-131834489 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0033544	protein coding gene	Chr7:137267843-137292897 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030517	protein coding gene	Chr7:129781908-129808864 (+)
CAST/EiJ	MGP_CASTEiJ_G0032078	protein coding gene	Chr7:123606484-123633085 (+)
CBA/J	MGP_CBAJ_G0032722	protein coding gene	Chr7:141912387-141942207 (+)
DBA/2J	MGP_DBA2J_G0032874	protein coding gene	Chr7:126564605-126589604 (+)
FVB/NJ	MGP_FVBNJ_G0032827	protein coding gene	Chr7:126420385-126445082 (+)
LP/J	MGP_LPJ_G0032968	protein coding gene	Chr7:133590542-133615163 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032859	protein coding gene	Chr7:142999343-143026432 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033564	protein coding gene	Chr7:130896778-130923772 (+)
PWK/PhJ	MGP_PWKPhJ_G0031785	protein coding gene	Chr7:119576413-119601330 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0031631	protein coding gene	Chr7:117700438-117729786 (+)
WSB/EiJ	MGP_WSBEiJ_G0032190	protein coding gene	Chr7:131864845-131891297 (+)

Human Ortholog

FBXL19, F-box and leucine rich repeat protein 19

Vertebrate Orthologs

6

Human Ortholog

FBXL19, F-box and leucine rich repeat protein 19
Orthology source: HomoloGene, HGNC
Synonyms

CXXC11, Fbl19, JHDM1C
Links

HGNC:25300

NCBI Gene ID: 54620

neXtProt AC: NX_Q6PCT2

UniProt: Q6PCT2
Chr Location

16p11.2; chr16:30923055-30948783 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 129692
1 human;1 mouse;1 cattle;1 dog;1 zebrafish;1 macaque, rhesus
HCOP

human homology predictions: FBXL19
Gene Tree

Fbxl19

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

17
Gene trapped

14
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

12 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

7
GO References

4

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

32
Tissues

23
cDNA Data

60
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase fbxl19

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Fbxl19 interacts with 181 markers (Mir1b, Mir16-1, Mir18, ...) View All

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All Sequences

62
RefSeq

14
UniProt

5
CCDS

CCDS21877.1
UniGene

259353

Ensembl

ENSMUSG00000030811 (Evidence)
NCBI Gene

233902

			Length	Strain/Species	Flank
genomic	ENSMUSG00000030811	Ensembl Gene Model \| MGI Sequence Detail	24941	C57BL/6J	± kb
transcript	ENSMUST00000186207	Ensembl \| MGI Sequence Detail	3178	Not Applicable
polypeptide	ENSMUSP00000140303	Ensembl \| MGI Sequence Detail	674	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000007377 F-box/LRR-repeat protein 19

(term hierarchy)
InterPro Domains

IPR001810 F-box domain

IPR006553 Leucine-rich repeat, cysteine-containing subtype

IPR032675 Leucine-rich repeat domain superfamily

IPR002857 Zinc finger, CXXC-type

IPR011011 Zinc finger, FYVE/PHD-type

IPR019787 Zinc finger, PHD-finger

IPR001965 Zinc finger, PHD-type

IPR019786 Zinc finger, PHD-type, conserved site

IPR013083 Zinc finger, RING/FYVE/PHD-type

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All nucleic 61

cDNA 60

Primer pair 1

Microarray probesets 3

Summaries

All 38

Developmental Gene Expression 3

Gene Ontology 4

Phenotypes 9
Earliest

J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
Latest

J:204105 Wei J, et al., A new mechanism of RhoA ubiquitination and degradation: Roles of SCF(FBXL19) E3 ligase and Erk2. Biochim Biophys Acta. 2013 Dec;1833(12):2757-64

TSS for Fbxl19:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr69271	Chr7:127744299-127744321 (+)	-233 bp
Tssr69272	Chr7:127745532-127745544 (+)	995 bp
Tssr69273	Chr7:127745785-127745824 (+)	1,262 bp
Tssr69274	Chr7:127746254-127746321 (+)	1,745 bp
Tssr69275	Chr7:127746533-127746565 (+)	2,006 bp
Tssr69276	Chr7:127746566-127746581 (+)	2,031 bp
Tssr69277	Chr7:127746714-127746729 (+)	2,179 bp
Tssr69278	Chr7:127746737-127746747 (+)	2,199 bp
Tssr69279	Chr7:127748108-127748120 (+)	3,571 bp
Tssr69280	Chr7:127748137-127748155 (+)	3,603 bp
Tssr69281	Chr7:127748167-127748177 (+)	3,629 bp
Tssr69282	Chr7:127767447-127767468 (+)	22,915 bp
Tssr69283	Chr7:127767473-127767486 (+)	22,937 bp
Tssr69284	Chr7:127767504-127767517 (+)	22,968 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO)
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