Fbxl19 MGI Mouse Gene Detail - MGI:3039600 - F-box and leucine-rich repeat protein 19

Symbol

Fbxl19
Name

F-box and leucine-rich repeat protein 19
Synonyms

Fbl19

Feature Type

protein coding gene
IDs

MGI:3039600
NCBI Gene: 233902
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr7:127343715-127368655 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 69.71 cM
Mapping Data

1 experiment

SNPs within 2kb

513 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3039600	protein coding gene	Chr7:127343059-127368655 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0033051	protein coding gene	Chr7:132116211-132142330 (+)
A/J	MGP_AJ_G0033034	protein coding gene	Chr7:128583709-128608354 (+)
AKR/J	MGP_AKRJ_G0032966	protein coding gene	Chr7:131910394-131935132 (+)
BALB/cJ	MGP_BALBcJ_G0033035	protein coding gene	Chr7:128237235-128262886 (+)
C3H/HeJ	MGP_C3HHeJ_G0032749	protein coding gene	Chr7:131807098-131834489 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0033544	protein coding gene	Chr7:137267843-137292897 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030517	protein coding gene	Chr7:129781908-129808864 (+)
CAST/EiJ	MGP_CASTEiJ_G0032078	protein coding gene	Chr7:123606484-123633085 (+)
CBA/J	MGP_CBAJ_G0032722	protein coding gene	Chr7:141912387-141942207 (+)
DBA/2J	MGP_DBA2J_G0032874	protein coding gene	Chr7:126564605-126589604 (+)
FVB/NJ	MGP_FVBNJ_G0032827	protein coding gene	Chr7:126420385-126445082 (+)
LP/J	MGP_LPJ_G0032968	protein coding gene	Chr7:133590542-133615163 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032859	protein coding gene	Chr7:142999343-143026432 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033564	protein coding gene	Chr7:130896778-130923772 (+)
PWK/PhJ	MGP_PWKPhJ_G0031785	protein coding gene	Chr7:119576413-119601330 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0031631	protein coding gene	Chr7:117700438-117729786 (+)
WSB/EiJ	MGP_WSBEiJ_G0032190	protein coding gene	Chr7:131864845-131891297 (+)

Human Ortholog

FBXL19, F-box and leucine rich repeat protein 19

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FBXL19, F-box and leucine rich repeat protein 19
Synonyms

CXXC11, Fbl19, JHDM1C
Links

HGNC:25300

NCBI Gene ID: 54620

UniProt: Q6PCT2
Chr Location

16p11.2; chr16:30922851-30948783 (+) GRCh38

MGI Vertebrate Homology

Fbxl19 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: FBXL19
Gene Tree

Fbxl19

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Phenotype Summary

17 phenotypes from 2 alleles in 2 genetic backgrounds
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

23
Endonuclease-mediated

4
Gene trapped

13
Targeted

6
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

19 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele stop developing around E10.5 with growth retardation, underdeveloped facial mesenchyme , hypomorphic cardiac mesemchyme, decreased body length, and small limb buds.

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All GO Annotations

21
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

746
Tissues

31
cDNA Data

60
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase fbxl19

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All Sequences

64
RefSeq

16
UniProt

5
CCDS

CCDS21877.1, CCDS90334.1

Ensembl

ENSMUSG00000030811 (Evidence)
NCBI Gene

233902

			Length	Strain/Species	Flank
genomic	ENSMUSG00000030811	Ensembl Gene Model \| MGI Sequence Detail	24941	C57BL/6J	± kb
transcript	ENSMUST00000186207	Ensembl \| MGI Sequence Detail	3178	Not Applicable
polypeptide	ENSMUSP00000140303	Ensembl \| MGI Sequence Detail	674	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000007377 F-box/LRR-repeat protein 19

(term hierarchy)
InterPro Domains

IPR001810 F-box domain

IPR050648 F-box/Leucine-rich repeat

IPR050690 JHDM1 Histone Demethylase

IPR006553 Leucine-rich repeat, cysteine-containing subtype

IPR032675 Leucine-rich repeat domain superfamily

IPR002857 Zinc finger, CXXC-type

IPR011011 Zinc finger, FYVE/PHD-type

IPR019787 Zinc finger, PHD-finger

IPR001965 Zinc finger, PHD-type

IPR019786 Zinc finger, PHD-type, conserved site

IPR013083 Zinc finger, RING/FYVE/PHD-type
GlyGen

Q6PB97 2 sites

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All nucleic 62

cDNA 60

Primer pair 2

Microarray probesets 3

Summaries

All 48

Developmental Gene Expression 3

Gene Ontology 8

Phenotypes 14
Earliest

J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Fbxl19:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr69271	Chr7:127343471-127343493 (+)	-233 bp
Tssr69275	Chr7:127345705-127345737 (+)	2,006 bp
Tssr69276	Chr7:127345738-127345753 (+)	2,031 bp
Tssr69277	Chr7:127345886-127345901 (+)	2,179 bp
Tssr69278	Chr7:127345909-127345919 (+)	2,199 bp
Tssr69279	Chr7:127347280-127347292 (+)	3,571 bp
Tssr69280	Chr7:127347309-127347327 (+)	3,603 bp
Tssr69281	Chr7:127347339-127347349 (+)	3,629 bp
Tssr69282	Chr7:127366619-127366640 (+)	22,915 bp
Tssr69283	Chr7:127366645-127366658 (+)	22,937 bp
Tssr69284	Chr7:127366676-127366689 (+)	22,968 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/18/2025 MGI 6.24