BC048546
Gene Detail

Symbol Name ID

BC048546 cDNA sequence BC048546 MGI:3039594

Synonyms

MGC:58520

Feature Type

protein coding gene

Genetic Map

Chromosome 6

63.05 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr6:128539822-128581606 bp, - strand From NCBI annotation of GRCm38   41785 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:45969  Vertebrate Homology Class
2 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: alpha-2-macroglobulin
Gene Tree: BC048546

Human homologs

Human Homolog		OVOS, ovostatin
NCBI Gene ID		408186
Human Chr (Location)		12p13; chr12:9613794-9725776 (+)  GRCh37.p10
Human Homolog		OVOS2, ovostatin 2
NCBI Gene ID		144203
neXtProt AC		NX_Q6IE36
Human Chr (Location)		12p11.21; chr12:31267684-31359088 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(2) : Gene trapped(2)

Gene Ontology (GO) classifications

All GO classifications: (7 annotations)

Process	negative regulation of peptidase activity
Component	extracellular region, extracellular space
Function	endopeptidase inhibitor activity, peptidase inhibitor activity, ...

External Resources: FuncBase

Expression

cDNA source data(179)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(179) cDNA(179)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000047228 (Evidence)
Entrez Gene	232400 (Evidence)
UniGene	259234
DFCI	TC1576387, TC1587334
DoTS	DT.40140119, DT.94245199, DT.99839110
NIA Mouse Gene Index	U027902
Consensus CDS Project	CCDS39651.1
International Mouse Knockout Project Status	BC048546

Sequences

Length	Strain/Species
genomic	232400	NCBI Gene Model | MGI Sequence Detail	41785	C57BL/6J
transcript	NM_001001179	RefSeq | MGI Sequence Detail	4698	C57BL/6
polypeptide	Q3UU35	UniProt | EBI | MGI Sequence Detail	1456	Not Applicable

All sequences(28) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(342 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001599	Alpha-2-macroglobulin
InterPro	IPR019742	Alpha-2-macroglobulin, conserved site
InterPro	IPR002890	Alpha-2-macroglobulin, N-terminal
InterPro	IPR011625	Alpha-2-macroglobulin, N-terminal 2
InterPro	IPR019565	Alpha-2-macroglobulin, thiol-ester bond-forming
InterPro	IPR009048	Alpha-macroglobulin, receptor-binding
InterPro	IPR011626	A-macroglobulin complement component
InterPro	IPR008930	Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
Protein Ontology	PR:000012184	ovostatin

Graphical View of Protein Domain Structure

References

(Earliest) J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
(Latest) J:152068 Friedel RH, et al., EUCOMM--the European conditional mouse mutagenesis program. Brief Funct Genomic Proteomic. 2007 Sep;6(3):180-5
All references(25)