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BC048546
Gene Detail
Symbol

Name
ID
BC048546
cDNA sequence BC048546
MGI:3039594
Synonyms
MGC:58520
Feature Type
protein coding gene
Genetic Map
Chromosome 6
63.05 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr6:128539822-128581606 bp, - strand
From NCBI annotation of GRCm38

  41785 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:45969  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

HCOP human homology predictions: OVOS2
Protein SuperFamily: alpha-2-macroglobulin
Gene Tree: BC048546

Human
homologs
OVOS2, ovostatin 2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 144203
neXtProt AC: NX_Q6IE36

Human Chr (Location): 12p11.21; chr12:31111657-31232532 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Gene trapped(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Interactions
BC048546 interacts with 55 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process negative regulation of peptidase activity
Component extracellular region, extracellular space
Function endopeptidase inhibitor activity, peptidase inhibitor activity, ...
External Resources: FuncBase
Expression
cDNA source data(179)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase LOC100487907    NEW 
Molecular
reagents
All nucleic(179) cDNA(179)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000047228 (Evidence)
Entrez Gene 232400 (Evidence)
UniGene 259234
DFCI TC1587334, TC1576387
DoTS DT.94245199, DT.40140119, DT.99839110
NIA Mouse Gene Index U027902
Consensus CDS Project CCDS39651.1
International Mouse Phenotyping Consortium Status BC048546
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 232400 NCBI Gene Model | MGI Sequence Detail 41785 C57BL/6J ±  kb
transcript NM_001001179 RefSeq | MGI Sequence Detail 4698 C57BL/6 
polypeptide Q3UU35 UniProt | EBI | MGI Sequence Detail 1456 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(2) UniProt(4)
Polymorphisms
SNPs within 2kb(525 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001599 Alpha-2-macroglobulin
InterPro IPR019742 Alpha-2-macroglobulin, conserved site
InterPro IPR002890 Alpha-2-macroglobulin, N-terminal
InterPro IPR011625 Alpha-2-macroglobulin, N-terminal 2
InterPro IPR019565 Alpha-2-macroglobulin, thiol-ester bond-forming
InterPro IPR009048 Alpha-macroglobulin, receptor-binding
InterPro IPR011626 A-macroglobulin complement component
InterPro IPR014756 Immunoglobulin E-set
InterPro IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
Protein Ontology PR:000012184 ovostatin
Graphical View of Protein Domain Structure
References
(Earliest) J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
(Latest) J:152068 Friedel RH, et al., EUCOMM--the European conditional mouse mutagenesis program. Brief Funct Genomic Proteomic. 2007 Sep;6(3):180-5
All references(24)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory