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BC048546
Gene Detail
 Symbol
Name
ID
BC048546
cDNA sequence BC048546
MGI:3039594
Synonyms MGC:58520
Feature Type protein coding gene
Genetic Map
Chromosome 6
63.05 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr6:128539822-128581606 bp, - strand
From NCBI annotation of GRCm38

  41785 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:45969  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: alpha-2-macroglobulin
Gene Tree: BC048546

Human
homologs
Human Homolog OVOS2, ovostatin 2
NCBI Gene ID 144203
neXtProt AC  NX_Q6IE36
Human Chr (Location)  12p11.21; chr12:31111657-31201228 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Gene trapped(2)
Incidental mutations (data from Mutagenetix , APF )
Interactions
BC048546 interacts with 55 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process negative regulation of peptidase activity
Component extracellular region, extracellular space
Function endopeptidase inhibitor activity, peptidase inhibitor activity, ...
External Resources: FuncBase
Expression
cDNA source data(179)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(179) cDNA(179)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000047228 (Evidence)
Entrez Gene232400 (Evidence)
UniGene259234
DFCITC1576387, TC1587334
DoTSDT.40140119, DT.94245199, DT.99839110
NIA Mouse Gene IndexU027902
Consensus CDS ProjectCCDS39651.1
International Mouse Knockout Project StatusBC048546
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 232400 NCBI Gene Model | MGI Sequence Detail 41785 C57BL/6J ±  kb
transcript NM_001001179 RefSeq | MGI Sequence Detail 4698 C57BL/6 
polypeptide Q3UU35 UniProt | EBI | MGI Sequence Detail 1456 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(4) UniProt(4)
Polymorphisms SNPs within 2kb(525 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001599 Alpha-2-macroglobulin
InterPro IPR019742 Alpha-2-macroglobulin, conserved site
InterPro IPR002890 Alpha-2-macroglobulin, N-terminal
InterPro IPR011625 Alpha-2-macroglobulin, N-terminal 2
InterPro IPR019565 Alpha-2-macroglobulin, thiol-ester bond-forming
InterPro IPR009048 Alpha-macroglobulin, receptor-binding
InterPro IPR011626 A-macroglobulin complement component
InterPro IPR014756 Immunoglobulin E-set
InterPro IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
Protein Ontology PR:000012184 ovostatin
Graphical View of Protein Domain Structure
References (Earliest) J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
(Latest) J:152068 Friedel RH, et al., EUCOMM--the European conditional mouse mutagenesis program. Brief Funct Genomic Proteomic. 2007 Sep;6(3):180-5
All references(25)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory