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Orai3 Gene Detail
Summary
  • Symbol
    Orai3
  • Name
    ORAI calcium release-activated calcium modulator 3
  • Synonyms
    Tmem142c
  • Feature Type
    protein coding gene
  • IDs
    MGI:3039586
    NCBI Gene: 269999
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:127368987-127374322 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 69.73 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    102 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3039586
 protein coding gene Chr7:127368987-127374322 (+)
129S1/SvImJ ENSMUSG00200022203
 protein coding gene Chr7:113881980-113887315 (+)
A/J ENSMUSG00195035476
 protein coding gene Chr7:118383651-118388991 (+)
AKR/J ENSMUSG00220015626
 protein coding gene Chr7:111830659-111835994 (+)
BALB/cJ ENSMUSG00180011198
 protein coding gene Chr7:115071498-115076833 (+)
C3H/HeJ ENSMUSG00175016081
 protein coding gene Chr7:115798395-115803730 (+)
C57BL/6NJ ENSMUSG00215007416
 protein coding gene Chr7:115078714-115084049 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030518
 protein coding gene Chr7:129809196-129814525 (+)
CAST/EiJ ENSTCUG00005045386
 protein coding gene Chr7:118324972-118330313 (+)
CBA/J ENSMUSG00210022936
 protein coding gene Chr7:115559743-115565078 (+)
DBA/2J ENSMUSG00185041120
 protein coding gene Chr7:119872570-119877905 (+)
FVB/NJ ENSMUSG00205016603
 protein coding gene Chr7:115515566-115520901 (+)
JF1/MsJ ENSUMUG00000009204
 protein coding gene Chr7:124923532-124928867 (+)
LP/J ENSMUSG00230052124
 protein coding gene Chr7:125981902-125987237 (+)
NOD/ShiLtJ ENSMUSG00190016671
 protein coding gene Chr7:115709963-115715298 (+)
NZO/HlLtJ ENSMUSG00225011115
 protein coding gene Chr7:124211656-124216991 (+)
PWK/PhJ ENSLUMG00010032684
 protein coding gene Chr7:114060188-114065523 (+)
SPRET/EiJ ENSMSPG00010009877
 protein coding gene Chr7:115319849-115325186 (+)
WSB/EiJ ENSIUOG00005029426
 protein coding gene Chr7:116410067-116415402 (+)



Homology
more
  • Human Ortholog
    ORAI3, ORAI calcium release-activated calcium modulator 3
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ORAI3, ORAI calcium release-activated calcium modulator 3
  • Synonyms
    TMEM142C
  • Links
    NCBI Gene ID: 93129
    UniProt: Q9BRQ5

  • Chr Location
    16p11.2; chr16:30949068-30956461 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    5 phenotypes from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice with loss of expression in B cells display increased viability of anti-IgM stimulated B cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    32
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 269999 NCBI Gene Model | MGI Sequence Detail 5336 C57BL/6J ±  kb
    transcript NM_198424 RefSeq | MGI Sequence Detail 1996 C57BL/6  
    polypeptide Q6P8G8 UniProt | EBI | MGI Sequence Detail 290 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 32
      cDNA 32

      Microarray probesets 1
    References
    more
    • Summaries
      All 43
      Gene Ontology 7
      Phenotypes 12
    • Earliest
      J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
    • Latest
      J:352176 Oliveira TY, et al., Quantitative trait loci mapping provides insights into the genetic regulation of dendritic cell numbers in mouse tissues. Cell Rep. 2024 Jun 25;43(6):114296
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory