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Lmtk3 Gene Detail
Summary
  • Symbol
    Lmtk3
  • Name
    lemur tyrosine kinase 3
  • Synonyms
    Aatyk3, AATYK3
  • Feature Type
    protein coding gene
  • IDs
    MGI:3039582
    NCBI Gene: 381983
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr7:45783738-45804144 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      20407 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 29.50 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    LMTK3, lemur tyrosine kinase 3
  • Vertebrate Orthologs
    7
  • Human Ortholog
    LMTK3, lemur tyrosine kinase 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    LMR3, PPP1R101, TYKLM3
  • Links
    NCBI Gene ID: 114783
    neXtProt AC: NX_Q96Q04
    UniProt: Q96Q04

  • Chr Location
    19q13.33; chr19:48485271-48513926 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit pronounced behavioral abnormalities, including locomotor hyperactivity, reduced anxiety, and decreased depression-like behavior, an increased striatal dopamine turnover rate, and enhanced behavioral response to methylphenidate.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029694 VEGA Gene Model | MGI Sequence Detail 20407 C57BL/6J ±  kb
transcript OTTMUST00000073674 VEGA | MGI Sequence Detail 5051 Not Applicable  
polypeptide OTTMUSP00000038175 VEGA | MGI Sequence Detail 1450 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    193 from dbSNP Build 142
Protein
Information
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  • UniProt
    7 Sequences
  • EC
  • InterPro Domains
    IPR017441 Protein kinase, ATP binding site
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain superfamily
    IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
    IPR008266 Tyrosine-protein kinase, active site
Molecular
Reagents
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  • All nucleic 6
    cDNA 6

    Microarray probesets 4
References
more
  • Summaries
    All 24
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 5
  • Earliest
    J:128285 Tomomura M, et al., Structural and functional analysis of the apoptosis-associated tyrosine kinase (AATYK) family. Neuroscience. 2007 Aug 24;148(2):510-21
  • Latest
    J:210612 Inoue T, et al., LMTK3 deficiency causes pronounced locomotor hyperactivity and impairs endocytic trafficking. J Neurosci. 2014 Apr 23;34(17):5927-37

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/07/2017
MGI 6.11
The Jackson Laboratory