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Dlgap3
Gene Detail
 Symbol
Name
ID
Dlgap3
discs, large (Drosophila) homolog-associated protein 3
MGI:3039563
Synonyms DAP3, Prpl8, PSD-95/SAP90-binding protein 3, SAP90/PSD 95 associated protein 3, Sapap3
Feature Type protein coding gene
Genetic Map
Chromosome 4
61.33 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr4:127169204-127237022 bp, + strand
From VEGA annotation of GRCm38

  67819 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:18276  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Dlgap3

Human
homologs
Human Homolog DLGAP3, discs, large (Drosophila) homolog-associated protein 3
NCBI Gene ID 58512
neXtProt AC  NX_O95886
Human Synonyms  DAP3, SAPAP3
Human Chr (Location)  1p35.3-p34.1; chr1:34865436-34925482 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(69) : Gene trapped(65) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit skin lesions associated with excessive grooming, increased anxiety-related behaviors, altered synaptic transmission and abnormal sleep patterns.
 
Human Diseases Modeled Using Mouse Dlgap3 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Dlgap3 interacts with 141 markers (Mir22, Mir23a, Mir25, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process cell-cell signaling, protein complex assembly
Component cell junction, dendritic spine, ...
Function beta-amyloid binding, PDZ domain binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(27)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(27) cDNA(27)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000009331 (Evidence)
Ensembl Gene ModelENSMUSG00000042388 (Evidence)
Entrez Gene242667 (Evidence)
UniGene331885
DFCITC1582336
DoTSDT.101181933, DT.101336495, DT.40171640
NIA Mouse Gene IndexU004839
Consensus CDS ProjectCCDS18665.1
International Mouse Knockout Project StatusDlgap3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009331 VEGA Gene Model | MGI Sequence Detail 67819 C57BL/6J ±  kb
transcript OTTMUST00000021211 VEGA | MGI Sequence Detail 3884 Not Applicable 
polypeptide OTTMUSP00000009703 VEGA | MGI Sequence Detail 977 Not Applicable 

For the selected sequences
All sequences(42) RefSeq(8) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(437 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005026 Guanylate-kinase-associated protein
Protein Ontology PR:000006518 disks large-associated protein 3
References (Earliest) J:39869 Yehiely F, et al., Identification of candidate proteins binding to prion protein. Neurobiol Dis. 1997;3(4):339-55
(Latest) J:199175 Burguiere E, et al., Optogenetic stimulation of lateral orbitofronto-striatal pathway suppresses compulsive behaviors. Science. 2013 Jun 7;340(6137):1243-6
All references(42)
Disease annotation references (1)
Other
accession IDs
MGI:892992

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory