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Dlgap3 Gene Detail
Summary
  • Symbol
    Dlgap3
  • Name
    DLG associated protein 3
  • Synonyms
    DAP3, Prpl8, PSD-95/SAP90-binding protein 3, SAP90/PSD 95 associated protein 3, Sapap3
  • Feature Type
    protein coding gene
  • IDs
    MGI:3039563
    NCBI Gene: 242667
  • Alliance
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:127169204-127237022 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 61.33 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    435 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3039563
protein coding gene Chr4:127168305-127237022 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028794
protein coding gene Chr4:128906907-128979805 (+)
A/J MGP_AJ_G0028753
protein coding gene Chr4:123823267-123895417 (+)
AKR/J MGP_AKRJ_G0028706
protein coding gene Chr4:127224066-127303023 (+)
BALB/cJ MGP_BALBcJ_G0028776
protein coding gene Chr4:124390987-124459895 (+)
C3H/HeJ MGP_C3HHeJ_G0028490
protein coding gene Chr4:127301206-127372860 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029218
protein coding gene Chr4:133812226-133889356 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026491
protein coding gene Chr4:116946264-117013924 (+)
CAST/EiJ MGP_CASTEiJ_G0027923
protein coding gene Chr4:125424048-125497644 (+)
CBA/J MGP_CBAJ_G0028456
protein coding gene Chr4:137068091-137160409 (+)
DBA/2J MGP_DBA2J_G0028605
protein coding gene Chr4:124267048-124335937 (+)
FVB/NJ MGP_FVBNJ_G0028572
protein coding gene Chr4:122930200-122997201 (+)
LP/J MGP_LPJ_G0028706
protein coding gene Chr4:129193413-129270389 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028598
protein coding gene Chr4:142067198-142139172 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029256
protein coding gene Chr4:127602082-127674971 (+)
PWK/PhJ MGP_PWKPhJ_G0027644
protein coding gene Chr4:120771448-120846865 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027471
protein coding gene Chr4:123418113-123490214 (+)
WSB/EiJ MGP_WSBEiJ_G0028003
protein coding gene Chr4:127709108-127782027 (+)



Homology
more
  • Human Ortholog
    DLGAP3, DLG associated protein 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DLGAP3, DLG associated protein 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DAP3, SAPAP3
  • Links
    NCBI Gene ID: 58512
    neXtProt AC: NX_O95886
    UniProt: O95886

  • Chr Location
    1p34.3; chr1:34862120-34929585 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 18276
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: DLGAP3
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit skin lesions associated with excessive grooming, increased anxiety-related behaviors, altered synaptic transmission and abnormal sleep patterns.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000042388 Ensembl Gene Model | MGI Sequence Detail 67819 C57BL/6J ±  kb
transcript ENSMUST00000046659 Ensembl | MGI Sequence Detail 3884 Not Applicable  
polypeptide ENSMUSP00000039724 Ensembl | MGI Sequence Detail 977 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 28
    cDNA 28

    Microarray probesets 4
Other
Accession IDs
less
MGI:892992
References
more
  • Summaries
    All 51
    Developmental Gene Expression 2
    Gene Ontology 6
    Phenotypes 22
  • Earliest
    J:39869 Yehiely F, et al., Identification of candidate proteins binding to prion protein. Neurobiol Dis. 1997;3(4):339-55
  • Latest
    J:278631 Todorov G, et al., Amelioration of obsessive-compulsive disorder in three mouse models treated with one epigenetic drug: unraveling the underlying mechanism. Sci Rep. 2019 Jun 19;9(1):8741

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory