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Dlgap3 Gene Detail
Summary
  • Symbol
    Dlgap3
  • Name
    discs, large (Drosophila) homolog-associated protein 3
  • Synonyms
    DAP3, Prpl8, PSD-95/SAP90-binding protein 3, SAP90/PSD 95 associated protein 3, Sapap3
  • Feature Type
    protein coding gene
  • IDs
    MGI:3039563
    NCBI Gene: 242667
Location & Maps
more
  • Sequence Map
    Chr4:127169204-127237022 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      67819 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 61.33 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    DLGAP3, DLG associated protein 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DLGAP3, DLG associated protein 3
    Orthology source: HomoloGene
  • Synonyms
    DAP3, SAPAP3
  • Links
    NCBI Gene ID: 58512
    neXtProt AC: NX_O95886

  • Chr Location
    1p35.3-p34.1; chr1:34862120-34929585 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Dlgap3 mouse models

Human Disease Mouse Models
       Obsessive-Compulsive Disorder; OCD   OMIM: 164230 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    73
  • Chemically induced (other)
    2
  • Gene trapped
    65
  • Radiation induced
    1
  • Targeted
    5
  • Genomic Mutations
    4 involving Dlgap3
  • Incidental Mutations
Mice homozygous for a null allele exhibit skin lesions associated with excessive grooming, increased anxiety-related behaviors, altered synaptic transmission and abnormal sleep patterns.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009331 VEGA Gene Model | MGI Sequence Detail 67819 C57BL/6J ±  kb
transcript OTTMUST00000021211 VEGA | MGI Sequence Detail 3884 Not Applicable  
polypeptide OTTMUSP00000009703 VEGA | MGI Sequence Detail 977 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    435 from dbSNP Build 142
  • RFLP
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000006518 disks large-associated protein 3
  • PDB
  • InterPro Domains
    IPR030526 Disks large-associated protein 3
    IPR005026 SAPAP family
Molecular
Reagents
less
  • All nucleic 27
    cDNA 27

    Microarray probesets 4
Other
Accession IDs
less
MGI:892992
References
more
  • Summaries
    All 38
    Developmental Gene Expression 1
    Diseases 2
    Gene Ontology 5
    Phenotypes 18
  • Earliest
    J:39869 Yehiely F, et al., Identification of candidate proteins binding to prion protein. Neurobiol Dis. 1997;3(4):339-55
  • Latest
    J:232355 Ahmari SE, Using mice to model Obsessive Compulsive Disorder: From genes to circuits. Neuroscience. 2016 May 3;321:121-37

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory