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Dlgap3
Gene Detail
Symbol

Name
ID
Dlgap3
discs, large (Drosophila) homolog-associated protein 3
MGI:3039563
Synonyms
DAP3, Prpl8, PSD-95/SAP90-binding protein 3, SAP90/PSD 95 associated protein 3, Sapap3
Feature Type
protein coding gene
Genetic Map
Chromosome 4
61.33 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr4:127169204-127237022 bp, + strand
From VEGA annotation of GRCm38

  67819 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:18276  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: DLGAP3
Gene Tree: Dlgap3

Human
homologs
DLGAP3, discs, large (Drosophila) homolog-associated protein 3
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 58512
neXtProt AC: NX_O95886

Human Synonyms: DAP3, SAPAP3

Human Chr (Location): 1p35.3-p34.1; chr1:34862120-34929585 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(70) : Gene trapped(65) Targeted(5)
Genomic Mutations involving Dlgap3 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a null allele exhibit skin lesions associated with excessive grooming, increased anxiety-related behaviors, altered synaptic transmission and abnormal sleep patterns.
 
Human Diseases Modeled in Mice Using Dlgap3 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Dlgap3 interacts with 140 markers (Mir22, Mir23a, Mir25, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process protein complex assembly, signaling
Component cell junction, dendritic spine, ...
Function beta-amyloid binding, PDZ domain binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(27)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase dlgap3    NEW 
Molecular
reagents
All nucleic(27) cDNA(27)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000009331 (Evidence)
Ensembl Gene Model ENSMUSG00000042388 (Evidence)
Entrez Gene 242667 (Evidence)
UniGene 331885
DFCI TC1582336
DoTS DT.101181933, DT.101336495, DT.40171640
NIA Mouse Gene Index U004839
Consensus CDS Project CCDS18665.1
International Mouse Phenotyping Consortium Status Dlgap3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009331 VEGA Gene Model | MGI Sequence Detail 67819 C57BL/6J ±  kb
transcript OTTMUST00000021211 VEGA | MGI Sequence Detail 3884 Not Applicable 
polypeptide OTTMUSP00000009703 VEGA | MGI Sequence Detail 977 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(10) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(437 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005026 Guanylate-kinase-associated protein
Protein Ontology PR:000006518 disks large-associated protein 3
References
(Earliest) J:39869 Yehiely F, et al., Identification of candidate proteins binding to prion protein. Neurobiol Dis. 1997;3(4):339-55
(Latest) J:199175 Burguiere E, et al., Optogenetic stimulation of lateral orbitofronto-striatal pathway suppresses compulsive behaviors. Science. 2013 Jun 7;340(6137):1243-6
All references(40)
Disease annotation references (1)
Other
accession IDs
MGI:892992

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory