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Cerkl
Gene Detail
Symbol

Name
ID
Cerkl
ceramide kinase-like
MGI:3037816
Synonyms
Rp26
Feature Type
protein coding gene
Genetic Map
Chromosome 2
47.43 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr2:79330543-79456785 bp, - strand
From VEGA annotation of GRCm38

  126243 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:52396  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Cerkl

Human
homologs
Human Homolog CERKL, ceramide kinase-like
NCBI Gene ID 375298
neXtProt AC  NX_Q49MI3
Human Synonyms  RP26
Human Chr (Location)  2q31.3; chr2:181536672-181657107 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human CERKL
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Genomic Mutations involving Cerkl (2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a hypomorphic allele exhibit retinal apoptosis and decreased amplitudes and increased implicit time of oscillatory potentials.
 
Interactions
Cerkl interacts with 15 markers (Mir125b-2, Mir144, Mir217, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Process negative regulation of apoptotic process
Component cytoplasm, endoplasmic reticulum, ...
Expression
Literature Summary: (2 records)
Data Summary: Results (31)    Tissues (18)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 8
Western blot 2
RT-PCR 21
cDNA source data(1)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(4) cDNA(1) Primer pair(1) Other(2)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000013312 (Evidence)
Ensembl Gene ModelENSMUSG00000075256 (Evidence)
Entrez Gene228094 (Evidence)
DFCITC1614302, TC1607527, TC1584740, TC1776567, TC1654342
NIA Mouse Gene IndexU022792
Consensus CDS ProjectCCDS38157.1
International Mouse Knockout Project StatusCerkl
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000013312 VEGA Gene Model | MGI Sequence Detail 126243 C57BL/6J ±  kb
transcript OTTMUST00000032178 VEGA | MGI Sequence Detail 1623 Not Applicable 
polypeptide OTTMUSP00000014303 VEGA | MGI Sequence Detail 525 Not Applicable 

For the selected sequences
All sequences(130) RefSeq(17) UniProt(36)
Polymorphisms
SNPs within 2kb(690 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016064 ATP-NAD kinase-like domain
InterPro IPR001206 Diacylglycerol kinase, catalytic domain
Protein Ontology PR:000005364 ceramide kinase-like protein
References
(Earliest) J:137892 Graf C, et al., Wild-type levels of ceramide and ceramide-1-phosphate in the retina of ceramide kinase-like-deficient mice. Biochem Biophys Res Commun. 2008 Aug 15;373(1):159-63
(Latest) J:210433 Mandal NA, et al., Expression and localization of CERKL in the mammalian retina, its response to light-stress, and relationship with NeuroD1 gene. Exp Eye Res. 2013 Jan;106:24-33
All references(25)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory