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Cerkl Gene Detail
Summary
  • Symbol
    Cerkl
  • Name
    ceramide kinase-like
  • Synonyms
    Rp26
  • Feature Type
    protein coding gene
  • IDs
    MGI:3037816
    NCBI Gene: 228094
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:79162835-79259332 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 47.43 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    785 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3037816
 protein coding gene Chr2:79160887-79287129 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025877
 protein coding gene Chr2:79872306-80004960 (-)
A/J MGP_AJ_G0025854
 protein coding gene Chr2:76783992-76915854 (-)
AKR/J MGP_AKRJ_G0025823
 protein coding gene Chr2:78795736-78919531 (-)
BALB/cJ MGP_BALBcJ_G0025850
 protein coding gene Chr2:76910662-77037642 (-)
C3H/HeJ MGP_C3HHeJ_G0025609
 protein coding gene Chr2:79020082-79148186 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026296
 protein coding gene Chr2:82238858-82377873 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023699
 protein coding gene Chr2:74036432-74161219 (-)
CAST/EiJ MGP_CASTEiJ_G0025071
 protein coding gene Chr2:79441121-79569955 (-)
CBA/J MGP_CBAJ_G0025590
 protein coding gene Chr2:85183447-85341928 (-)
DBA/2J MGP_DBA2J_G0025721
 protein coding gene Chr2:76336795-76464214 (-)
FVB/NJ MGP_FVBNJ_G0025683
 protein coding gene Chr2:75704983-75832112 (-)
LP/J MGP_LPJ_G0025809
 protein coding gene Chr2:79716868-79855209 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025714
 protein coding gene Chr2:87035873-87176281 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026352
 protein coding gene Chr2:78963767-79093360 (-)
PWK/PhJ MGP_PWKPhJ_G0024814
 protein coding gene Chr2:76281844-76408114 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024620
 protein coding gene Chr2:79227193-79355029 (-)
WSB/EiJ MGP_WSBEiJ_G0025140
 protein coding gene Chr2:79590801-79723840 (-)



Homology
more
  • Human Ortholog
    CERKL, ceramide kinase like
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CERKL, ceramide kinase like
  • Synonyms
    RP26
  • Links
    NCBI Gene ID: 375298
    neXtProt AC: NX_Q49MI3
    UniProt: Q49MI3

  • Chr Location
    2q31.3; chr2:181536672-181657107 (-)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with Cerkl mouse models; 2 with human CERKL associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 4 alleles in 4 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a hypomorphic allele exhibit retinal apoptosis and decreased amplitudes and increased implicit time of oscillatory potentials.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    703
  • Tissues
    19
  • cDNA Data
    1
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 228094 NCBI Gene Model | MGI Sequence Detail 96498 C57BL/6J ±  kb
    transcript NM_001048176 RefSeq | MGI Sequence Detail 1759 C57BL/6  
    polypeptide NP_001041641 RefSeq | MGI Sequence Detail 525 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      16 Sequences
    • Protein Ontology
      PR:000005364 ceramide kinase-like protein
      (term hierarchy)
    • InterPro Domains
      IPR045363 Ceramide kinase, C-terminal domain
      IPR001206 Diacylglycerol kinase, catalytic domain
      IPR017438 Inorganic polyphosphate/ATP-NAD kinase, N-terminal
      IPR016064 NAD kinase/diacylglycerol kinase-like domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 2
      cDNA 1
      Primer pair 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 6
      Phenotypes 16
    • Earliest
      J:100298 Spitz F, et al., Inversion-induced disruption of the Hoxd cluster leads to the partition of regulatory landscapes. Nat Genet. 2005 Aug;37(8):889-93
    • Latest
      J:307395 Mirra S, et al., CERKL, a retinal dystrophy gene, regulates mitochondrial function and dynamics in the mammalian retina. Neurobiol Dis. 2021 Aug;156:105405
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    08/09/2022
    MGI 6.21     		The Jackson Laboratory