Cerkl MGI Mouse Gene Detail - MGI:3037816

Symbol

Cerkl
Name

ceramide kinase-like
Synonyms

Rp26

Feature Type

protein coding gene
IDs

MGI:3037816
NCBI Gene: 228094
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr2:79332491-79428988 bp, - strand
From NCBI annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 47.43 cM
Mapping Data

1 experiment

SNPs within 2kb

785 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3037816	protein coding gene	Chr2:79330543-79456785 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0025877	protein coding gene	Chr2:79872306-80004960 (-)
A/J	MGP_AJ_G0025854	protein coding gene	Chr2:76783992-76915854 (-)
AKR/J	MGP_AKRJ_G0025823	protein coding gene	Chr2:78795736-78919531 (-)
BALB/cJ	MGP_BALBcJ_G0025850	protein coding gene	Chr2:76910662-77037642 (-)
C3H/HeJ	MGP_C3HHeJ_G0025609	protein coding gene	Chr2:79020082-79148186 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0026296	protein coding gene	Chr2:82238858-82377873 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023699	protein coding gene	Chr2:74036432-74161219 (-)
CAST/EiJ	MGP_CASTEiJ_G0025071	protein coding gene	Chr2:79441121-79569955 (-)
CBA/J	MGP_CBAJ_G0025590	protein coding gene	Chr2:85183447-85341928 (-)
DBA/2J	MGP_DBA2J_G0025721	protein coding gene	Chr2:76336795-76464214 (-)
FVB/NJ	MGP_FVBNJ_G0025683	protein coding gene	Chr2:75704983-75832112 (-)
LP/J	MGP_LPJ_G0025809	protein coding gene	Chr2:79716868-79855209 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025714	protein coding gene	Chr2:87035873-87176281 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026352	protein coding gene	Chr2:78963767-79093360 (-)
PWK/PhJ	MGP_PWKPhJ_G0024814	protein coding gene	Chr2:76281844-76408114 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0024620	protein coding gene	Chr2:79227193-79355029 (-)
WSB/EiJ	MGP_WSBEiJ_G0025140	protein coding gene	Chr2:79590801-79723840 (-)

Human Ortholog

CERKL, ceramide kinase like

Vertebrate Orthologs

9

Human Ortholog

CERKL, ceramide kinase like
Orthology source: HomoloGene, HGNC
Synonyms

RP26
Links

HGNC:21699

NCBI Gene ID: 375298

neXtProt AC: NX_Q49MI3

UniProt: Q49MI3
Chr Location

2q31.3; chr2:181536672-181657107 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 52396
1 human;1 mouse;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: CERKL
Gene Tree

Cerkl

Diseases

1 with human CERKL associations

				Human Disease	Mouse Models
				retinitis pigmentosa 26 IDs retinitis pigmentosa 26 DOID:0110368 ICD10CM:H35.5 OMIM:608380

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

3 phenotypes from 2 alleles in 2 genetic backgrounds
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Targeted

6
Genomic Mutations

3 involving Cerkl
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

16 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a hypomorphic allele exhibit retinal apoptosis and decreased amplitudes and increased implicit time of oscillatory potentials.

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All GO Annotations

20
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

662
Tissues

19
cDNA Data

1
Literature Summary

2

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cerkl

ZFIN cerkl

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Cerkl interacts with 14 markers (Mir125b-2, Mir144, Mir217, ...) View All

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All Sequences

79
RefSeq

2
UniProt

16
CCDS

CCDS38157.1

Ensembl

ENSMUSG00000075256 (Evidence)
NCBI Gene

228094

			Length	Strain/Species	Flank
genomic	228094	NCBI Gene Model \| MGI Sequence Detail	96498	C57BL/6J	± kb
transcript	NM_001048176	RefSeq \| MGI Sequence Detail	1759	C57BL/6
polypeptide	NP_001041641	RefSeq \| MGI Sequence Detail	525	C57BL/6

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UniProt

16 Sequences
Protein Ontology

PR:000005364 ceramide kinase-like protein

(term hierarchy)
InterPro Domains

IPR001206 Diacylglycerol kinase, catalytic domain

IPR017438 Inorganic polyphosphate/ATP-NAD kinase, N-terminal

IPR016064 NAD kinase/diacylglycerol kinase-like domain superfamily

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All nucleic 2

cDNA 1

Primer pair 1

Microarray probesets 2

Summaries

All 32

Developmental Gene Expression 2

Gene Ontology 6

Phenotypes 12
Earliest

J:100298 Spitz F, et al., Inversion-induced disruption of the Hoxd cluster leads to the partition of regulatory landscapes. Nat Genet. 2005 Aug;37(8):889-93
Latest

J:292626 Domenech EB, et al., A New Cerkl Mouse Model Generated by CRISPR-Cas9 Shows Progressive Retinal Degeneration and Altered Morphological and Electrophysiological Phenotype. Invest Ophthalmol Vis Sci. 2020 Jul 1;61(8):14

TSS for Cerkl:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr24890	Chr2:79428958-79428990 (-)	14 bp
Tssr24888	Chr2:79391558-79391561 (-)	37,428 bp
Tssr24887	Chr2:79370855-79370892 (-)	58,114 bp
Tssr24886	Chr2:79369103-79369127 (-)	59,873 bp
Tssr24885	Chr2:79369070-79369090 (-)	59,908 bp
Tssr24884	Chr2:79368858-79368868 (-)	60,125 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 02/23/2021 MGI 6.16