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Cerkl
Gene Detail
Symbol

Name
ID
Cerkl
ceramide kinase-like
MGI:3037816
Synonyms
Rp26
Feature Type
protein coding gene
Genetic Map
Chromosome 2
47.43 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr2:79330543-79456785 bp, - strand
From VEGA annotation of GRCm38

  126243 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:52396  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CERKL
Gene Tree: Cerkl

Human
homologs
CERKL, ceramide kinase-like
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 375298
neXtProt AC: NX_Q49MI3

Human Synonyms: RP26

Human Chr (Location): 2q31.3; chr2:181536672-181657107 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human CERKL

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Genomic Mutations involving Cerkl (2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a hypomorphic allele exhibit retinal apoptosis and decreased amplitudes and increased implicit time of oscillatory potentials.
 
Interactions
Cerkl interacts with 14 markers (Mir125b-2, Mir144, Mir217, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Process negative regulation of apoptotic process
Component cytoplasm, endoplasmic reticulum, ...
Expression
Literature Summary: (2 records)
Data Summary: Results (31)    Tissues (19)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 8
Western blot 2
RT-PCR 21
cDNA source data(1)
Other mouse links: GEO   Expression Atlas
Other vertebrate links: Xenbase cerkl ; ZFIN cerkl    NEW 
Molecular
reagents
All nucleic(4) cDNA(1) Primer pair(1) Other(2)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000013312 (Evidence)
Ensembl Gene Model ENSMUSG00000075256 (Evidence)
Entrez Gene 228094 (Evidence)
DFCI TC1776567, TC1654342, TC1584740, TC1614302, TC1607527
NIA Mouse Gene Index U022792
Consensus CDS Project CCDS38157.1
International Mouse Phenotyping Consortium Status Cerkl
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000013312 VEGA Gene Model | MGI Sequence Detail 126243 C57BL/6J ±  kb
transcript OTTMUST00000032178 VEGA | MGI Sequence Detail 1623 Not Applicable 
polypeptide OTTMUSP00000014303 VEGA | MGI Sequence Detail 525 Not Applicable 

For the selected sequences
All sequences(110) RefSeq(15) UniProt(18)
Polymorphisms
SNPs within 2kb(690 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016064 ATP-NAD kinase-like domain
InterPro IPR001206 Diacylglycerol kinase, catalytic domain
Protein Ontology PR:000005364 ceramide kinase-like protein
References
(Earliest) J:137892 Graf C, et al., Wild-type levels of ceramide and ceramide-1-phosphate in the retina of ceramide kinase-like-deficient mice. Biochem Biophys Res Commun. 2008 Aug 15;373(1):159-63
(Latest) J:212455 Li C, et al., CERKL interacts with mitochondrial TRX2 and protects retinal cells from oxidative stress-induced apoptosis. Biochim Biophys Acta. 2014 Jul;1842(7):1121-9
All references(25)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory