Cerkl
Gene Detail

Symbol Name ID

Cerkl ceramide kinase-like MGI:3037816

Synonyms

Rp26

Feature Type

protein coding gene

Genetic Map

Chromosome 2

47.43 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr2:79330543-79456785 bp, - strand From VEGA annotation of GRCm38   126243 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:52396  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Cerkl

Human homologs

Human Homolog		CERKL, ceramide kinase-like
NCBI Gene ID		375298
neXtProt AC		NX_Q49MI3
Human Synonyms		RP26
Human Chr (Location)		2q31.3; chr2:182401399-182521834 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human CERKL

Alleles and phenotypes

All alleles(2) : Targeted(2)
 

Mice homozygous for a hypomorphic allele exhibit retinal apoptosis and decreased amplitudes and increased implicit time of oscillatory potentials.

 

Gene Ontology (GO) classifications

All GO classifications: (8 annotations)

Process	negative regulation of apoptotic process, phosphorylation
Component	cytoplasm, endoplasmic reticulum, ...
Function	kinase activity, transferase activity

Expression

Literature Summary: (1 records)
cDNA source data(1)
External Resources: GEO   ArrayExpress

Molecular reagents

All nucleic(3) cDNA(1) Other(2)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000013312 (Evidence)
Ensembl Gene Model	ENSMUSG00000075256 (Evidence)
Entrez Gene	228094 (Evidence)
DFCI	TC1584740, TC1607527, TC1614302, TC1654342, TC1776567
NIA Mouse Gene Index	U022792
Consensus CDS Project	CCDS38157.1
International Mouse Knockout Project Status	Cerkl

Sequences

Length	Strain/Species
genomic	OTTMUSG00000013312	VEGA Gene Model | MGI Sequence Detail	126243	C57BL/6J
transcript	OTTMUST00000032178	VEGA | MGI Sequence Detail	1623	Not Applicable
polypeptide	OTTMUSP00000014303	VEGA | MGI Sequence Detail	525	Not Applicable

All sequences(98) RefSeq(3) UniProt(18)

Polymorphisms

SNPs within 2kb(690 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR016064	ATP-NAD kinase-like domain
InterPro	IPR001206	Diacylglycerol kinase, catalytic domain
Protein Ontology	PR:000005364	ceramide kinase-like protein

References

(Earliest) J:137892 Graf C, et al., Wild-type levels of ceramide and ceramide-1-phosphate in the retina of ceramide kinase-like-deficient mice. Biochem Biophys Res Commun. 2008 Aug 15;373(1):159-63
(Latest) J:185135 Garanto A, et al., Targeted knockdown of Cerkl, a retinal dystrophy gene, causes mild affectation of the retinal ganglion cell layer. Biochim Biophys Acta. 2012 Aug;1822(8):1258-69
All references(24)