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Cerkl Gene Detail
Summary
  • Symbol
    Cerkl
  • Name
    ceramide kinase-like
  • Synonyms
    Rp26
  • Feature Type
    protein coding gene
  • IDs
    MGI:3037816
    NCBI Gene: 228094
Location & Maps
more
  • Sequence Map
    Chr2:79330543-79456785 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      126243 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 47.43 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    CERKL, ceramide kinase like
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CERKL, ceramide kinase like
    Orthology source: HomoloGene, HGNC
  • Synonyms
    RP26
  • Links
    NCBI Gene ID: 375298
    neXtProt AC: NX_Q49MI3

  • Chr Location
    2q31.3; chr2:181536672-181657107 (-)  GRCh38.p2
  • HomoloGene
    Vertebrate Homology Class 52396
    1 human;1 mouse;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: CERKL
  • Gene Tree
    Cerkl
Human Diseases
more
  • Diseases
    1 with human CERKL associations

Human Disease Mouse Models
       Retinitis Pigmentosa 26; RP26   OMIM: 608380
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Targeted
    5
  • Genomic Mutations
    3 involving Cerkl
  • Incidental Mutations
    Mutagenetix , APF , CvDC
Mice homozygous for a hypomorphic allele exhibit retinal apoptosis and decreased amplitudes and increased implicit time of oscillatory potentials.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    31
  • Tissues
    19
  • cDNA Data
    1
  • Literature Summary
    2
  • Other Mouse Links
    GEO
  • Other Vertebrate Links
    Xenbase cerkl
    ZFIN cerkl
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000013312 VEGA Gene Model | MGI Sequence Detail 126243 C57BL/6J ±  kb
transcript OTTMUST00000032178 VEGA | MGI Sequence Detail 1623 Not Applicable  
polypeptide OTTMUSP00000014303 VEGA | MGI Sequence Detail 525 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    788 from dbSNP Build 142
Protein
Information
less
  • UniProt
    18 Sequences
  • InterPro Domains
    IPR001206 Diacylglycerol kinase, catalytic domain
    IPR016064 NAD kinase/diacylglycerol kinase-like domain
Molecular
Reagents
less
  • All nucleic 4
    cDNA 1
    Primer pair 1
    Other 2

    Microarray probesets 2
References
more
  • Summaries
    All 22
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 9
  • Earliest
    J:137892 Graf C, et al., Wild-type levels of ceramide and ceramide-1-phosphate in the retina of ceramide kinase-like-deficient mice. Biochem Biophys Res Commun. 2008 Aug 15;373(1):159-63
  • Latest
    J:212455 Li C, et al., CERKL interacts with mitochondrial TRX2 and protects retinal cells from oxidative stress-induced apoptosis. Biochim Biophys Acta. 2014 Jul;1842(7):1121-9
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/20/2016
MGI 6.05 		The Jackson Laboratory