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Kcnt2 Gene Detail
Summary
  • Symbol
    Kcnt2
  • Name
    potassium channel, subfamily T, member 2
  • Synonyms
    E330038N15Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:3036273
    NCBI Gene: 240776
Location & Maps
more
  • Sequence Map
    Chr1:140246158-140612067 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      365910 bp   ±  kb flank

  • Genome Browsers
Homology
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  • Human Ortholog
    KCNT2, potassium channel, sodium activated subfamily T, member 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    KCNT2, potassium channel, sodium activated subfamily T, member 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    KCa4.2, SLICK, SLO2.1
  • Links
    NCBI Gene ID: 343450
    neXtProt AC: NX_Q6UVM3

  • Chr Location
    1q31.3; chr1:196225779-196608560 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 16121
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: KCNT2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    9 phenotype references
  • All Mutations and Alleles
    29
  • Chemically induced (other)
    2
  • Gene trapped
    24
  • Targeted
    3
  • Genomic Mutations
    2 involving Kcnt2
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029830 VEGA Gene Model | MGI Sequence Detail 365910 C57BL/6J ±  kb
transcript OTTMUST00000074239 VEGA | MGI Sequence Detail 3540 Not Applicable  
polypeptide OTTMUSP00000038560 VEGA | MGI Sequence Detail 1135 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    1638 from dbSNP Build 137
Protein
Information
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  • UniProt
    5 Sequences
  • InterPro Domains
    IPR016040 NAD(P)-binding domain
    IPR003929 Potassium channel, calcium-activated, BK, alpha subunit
    IPR013099 Potassium channel domain
Molecular
Reagents
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  • All nucleic 1
    cDNA 1

    Microarray probesets 2
References
more
  • Summaries
    All 23
    Developmental Gene Expression 1
    Gene Ontology 2
    Phenotypes 9
  • Earliest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
  • Latest
    J:198109 Oeschger FM, et al., Gene expression analysis of the embryonic subplate. Cereb Cortex. 2012 Jun;22(6):1343-59

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory