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Kcnt2 Gene Detail
Summary
  • Symbol
    Kcnt2
  • Name
    potassium channel, subfamily T, member 2
  • Synonyms
    E330038N15Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:3036273
    NCBI Gene: 240776
  • Gene Overview
    MyGene.info: KCNT2
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:140246158-140612067 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 61.62 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1630 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3036273
protein coding gene Chr1:140245657-140613962 (.)
129S1/SvImJ MGP_129S1SvImJ_G0016559
protein coding gene Chr1:144390111-144788000 (+)
A/J MGP_AJ_G0016542
protein coding gene Chr1:138767019-139137486 (+)
AKR/J MGP_AKRJ_G0016507
protein coding gene Chr1:142987782-143363086 (+)
BALB/cJ MGP_BALBcJ_G0016502
protein coding gene Chr1:139138648-139510013 (+)
C3H/HeJ MGP_C3HHeJ_G0016327
protein coding gene Chr1:143121437-143501863 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016963
protein coding gene Chr1:149448746-149849173 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014672
protein coding gene Chr1:131849874-132200655 (+)
CAST/EiJ MGP_CASTEiJ_G0015906
protein coding gene Chr1:142477353-142873682 (+)
CBA/J MGP_CBAJ_G0016301
protein coding gene Chr1:154539573-154958048 (+)
DBA/2J MGP_DBA2J_G0016407
protein coding gene Chr1:137781002-138158948 (+)
FVB/NJ MGP_FVBNJ_G0016405
protein coding gene Chr1:136406198-136772356 (+)
LP/J MGP_LPJ_G0016478
protein coding gene Chr1:145539173-145928532 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016431
protein coding gene Chr1:160348187-160844733 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016999
protein coding gene Chr1:142722470-143097363 (+)
PWK/PhJ MGP_PWKPhJ_G0015692
protein coding gene Chr1:136747059-137119394 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015479
protein coding gene Chr1:141513964-141896928 (+)
WSB/EiJ MGP_WSBEiJ_G0015969
protein coding gene Chr1:142722796-143110872 (+)



Homology
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  • Human Ortholog
    KCNT2, potassium sodium-activated channel subfamily T member 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    KCNT2, potassium sodium-activated channel subfamily T member 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    EIEE57, KCa4.2, SLICK, SLO2.1
  • Links
    NCBI Gene ID: 343450
    neXtProt AC: NX_Q6UVM3
    UniProt: Q6UVM3

  • Chr Location
    1q31.3; chr1:196225779-196608905 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 16121
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: KCNT2
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human KCNT2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    5 phenotypes from multigenic genotypes
    11 phenotype references
Mice homozygous for a null allele are viable with normal pain and itch responses.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000052726 Ensembl Gene Model | MGI Sequence Detail 365910 C57BL/6J ±  kb
transcript ENSMUST00000120796 Ensembl | MGI Sequence Detail 3540 Not Applicable  
polypeptide ENSMUSP00000113333 Ensembl | MGI Sequence Detail 1135 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    5 Sequences
  • InterPro Domains
    IPR036291 NAD(P)-binding domain superfamily
    IPR003929 Potassium channel, BK, alpha subunit
    IPR013099 Potassium channel domain
Molecular
Reagents
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  • All nucleic 2
    cDNA 2

    Microarray probesets 2
References
more
  • Summaries
    All 31
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 11
  • Earliest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
  • Latest
    J:233623 Rizzi S, et al., Differential distribution of the sodium-activated potassium channels slick and slack in mouse brain. J Comp Neurol. 2016 Jul 1;524(10):2093-116

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory