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Kcnt2 Gene Detail
Summary
  • Symbol
    Kcnt2
  • Name
    potassium channel, subfamily T, member 2
  • Synonyms
    E330038N15Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:3036273
    NCBI Gene: 240776
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:140173896-140539805 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 1, 61.62 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1628 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3036273
protein coding gene Chr1:140173373-140541783 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016559
protein coding gene Chr1:144390111-144788000 (+)
A/J MGP_AJ_G0016542
protein coding gene Chr1:138767019-139137486 (+)
AKR/J MGP_AKRJ_G0016507
protein coding gene Chr1:142987782-143363086 (+)
BALB/cJ MGP_BALBcJ_G0016502
protein coding gene Chr1:139138648-139510013 (+)
C3H/HeJ MGP_C3HHeJ_G0016327
protein coding gene Chr1:143121437-143501863 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016963
protein coding gene Chr1:149448746-149849173 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014672
protein coding gene Chr1:131849874-132200655 (+)
CAST/EiJ MGP_CASTEiJ_G0015906
protein coding gene Chr1:142477353-142873682 (+)
CBA/J MGP_CBAJ_G0016301
protein coding gene Chr1:154539573-154958048 (+)
DBA/2J MGP_DBA2J_G0016407
protein coding gene Chr1:137781002-138158948 (+)
FVB/NJ MGP_FVBNJ_G0016405
protein coding gene Chr1:136406198-136772356 (+)
LP/J MGP_LPJ_G0016478
protein coding gene Chr1:145539173-145928532 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016431
protein coding gene Chr1:160348187-160844733 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016999
protein coding gene Chr1:142722470-143097363 (+)
PWK/PhJ MGP_PWKPhJ_G0015692
protein coding gene Chr1:136747059-137119394 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015479
protein coding gene Chr1:141513964-141896928 (+)
WSB/EiJ MGP_WSBEiJ_G0015969
protein coding gene Chr1:142722796-143110872 (+)



Homology
more
  • Human Ortholog
    KCNT2, potassium sodium-activated channel subfamily T member 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KCNT2, potassium sodium-activated channel subfamily T member 2
  • Synonyms
    DEE57, EIEE57, KCa4.2, SLICK, SLO2.1
  • Links
    NCBI Gene ID: 343450
    neXtProt AC: NX_Q6UVM3
    UniProt: Q6UVM3

  • Chr Location
    1q31.3; chr1:196225779-196609225 (-)  GRCh38

Human Diseases
more
  • Diseases
    1 with human KCNT2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 3 alleles in 3 genetic backgrounds
    5 phenotypes from multigenic genotypes
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele are viable with normal pain and itch responses.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000052726 Ensembl Gene Model | MGI Sequence Detail 365910 C57BL/6J ±  kb
    transcript ENSMUST00000120796 Ensembl | MGI Sequence Detail 3540 Not Applicable  
    polypeptide ENSMUSP00000113333 Ensembl | MGI Sequence Detail 1135 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • InterPro Domains
      IPR003929 Calcium-activated potassium channel BK, alpha subunit
      IPR047871 Calcium-activated potassium channel slowpoke-like
      IPR036291 NAD(P)-binding domain superfamily
      IPR013099 Potassium channel domain
    Molecular
    Reagents
    less
    • All nucleic 2
      cDNA 2

      Microarray probesets 2
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 1
      Gene Ontology 4
      Phenotypes 16
    • Earliest
      J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
    • Latest
      J:298060 Liu B, et al., An inducible circular RNA circKcnt2 inhibits ILC3 activation to facilitate colitis resolution. Nat Commun. 2020 Aug 14;11(1):4076

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory