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Pde11a
Gene Detail
 Symbol
Name
ID
Pde11a
phosphodiesterase 11A
MGI:3036251
Synonyms 6330414F14Rik, A630086N24Rik
Feature Type protein coding gene
Genetic Map
Chromosome 2
44.80 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:75989141-76338774 bp, - strand
From VEGA annotation of GRCm38

  349634 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56763  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: 3',5'-cyclic-GMP phosphodiesterase 5A
Gene Tree: Pde11a

Human
homologs
Human Homolog PDE11A, phosphodiesterase 11A
NCBI Gene ID 50940
neXtProt AC  NX_Q9HCR9
Human Synonyms  PPNAD2
Human Chr (Location)  2q31.2; chr2:177623249-178108339 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human PDE11A
Alleles
and
phenotypes
All alleles(3) : Targeted(2) Gene trapped(1)
 
Mice homozygous for a null allele have enlarged lateral ventricles and exhibit abnormal behavior.
 
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process cAMP catabolic process, cGMP catabolic process, ...
Component cytoplasm, perikaryon
Function 3',5'-cyclic-GMP phosphodiesterase activity, 3',5'-cyclic-nucleotide phosphodiesterase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (94)    Tissues (94)    Images (4)
Theiler Stages: 22
Assay TypeResults
RNA in situ 94
cDNA source data(3)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(5) Genomic(1) cDNA(4)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000015170 (Evidence)
Ensembl Gene ModelENSMUSG00000075270 (Evidence)
Entrez Gene241489 (Evidence)
UniGene246613
DFCITC1600577, TC1606562, TC1622522
DoTSDT.101143126, DT.110653726, DT.91278738, DT.91378873
NIA Mouse Gene IndexU022770
EC3.1.4.17, 3.1.4.35
Consensus CDS ProjectCCDS38152.1
International Mouse Knockout Project StatusPde11a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015170 VEGA Gene Model | MGI Sequence Detail 349634 C57BL/6J ±  kb
transcript OTTMUST00000035969 VEGA | MGI Sequence Detail 4189 Not Applicable 
polypeptide OTTMUSP00000016155 VEGA | MGI Sequence Detail 933 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(7) UniProt(4)
Polymorphisms SNPs within 2kb(3257 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023088 3'5'-cyclic nucleotide phosphodiesterase
InterPro IPR002073 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
InterPro IPR023174 3'5'-cyclic nucleotide phosphodiesterase, conserved site
InterPro IPR003018 GAF domain
InterPro IPR003607 HD/PDEase domain
Protein Ontology PR:000012464 dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:174459 Boyle MP, et al., Cell-type-specific consequences of Reelin deficiency in the mouse neocortex, hippocampus, and amygdala. J Comp Neurol. 2011 Aug 1;519(11):2061-89
All references(34)
Other
accession IDs
MGI:1923982

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/15/2014
MGI 5.17
The Jackson Laboratory