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Pde11a
Gene Detail
Symbol

Name
ID
Pde11a
phosphodiesterase 11A
MGI:3036251
Synonyms
6330414F14Rik, A630086N24Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 2
44.80 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:75989141-76338774 bp, - strand
From VEGA annotation of GRCm38

  349634 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56763  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PDE11A
Protein SuperFamily: 3',5'-cyclic-GMP phosphodiesterase 5A
Gene Tree: Pde11a

Human
homologs
PDE11A, phosphodiesterase 11A
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 50940
neXtProt AC: NX_Q9HCR9

Human Synonyms: PPNAD2

Human Chr (Location): 2q31.2; chr2:177623249-178108339 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human PDE11A

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Targeted(4)
Genomic Mutations involving Pde11a (2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele have enlarged lateral ventricles and exhibit abnormal behavior.
 
Interactions
Pde11a interacts with 245 markers (Mir7-2, Mir7b, Mir9-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (3 records)
Data Summary: Results (94)    Tissues (94)    Images (4)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
cDNA source data(3)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase pde11a    NEW 
Molecular
reagents
All nucleic(5) Genomic(1) cDNA(4)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000015170 (Evidence)
Ensembl Gene Model ENSMUSG00000075270 (Evidence)
Entrez Gene 241489 (Evidence)
UniGene 246613
DFCI TC1606562, TC1622522, TC1600577
DoTS DT.91278738, DT.101143126, DT.91378873, DT.110653726
NIA Mouse Gene Index U022770
EC 3.1.4.35, 3.1.4.17
Consensus CDS Project CCDS38152.1
International Mouse Phenotyping Consortium Status Pde11a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015170 VEGA Gene Model | MGI Sequence Detail 349634 C57BL/6J ±  kb
transcript OTTMUST00000035969 VEGA | MGI Sequence Detail 4189 Not Applicable 
polypeptide OTTMUSP00000016155 VEGA | MGI Sequence Detail 933 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(7) UniProt(4)
Polymorphisms
SNPs within 2kb(3257 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023088 3'5'-cyclic nucleotide phosphodiesterase
InterPro IPR002073 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
InterPro IPR023174 3'5'-cyclic nucleotide phosphodiesterase, conserved site
InterPro IPR003018 GAF domain
InterPro IPR003607 HD/PDEase domain
Protein Ontology PR:000012464 dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:205051 Miller JA, et al., Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Development. 2013 Nov;140(22):4633-44
All references(34)
Other
accession IDs
MGI:1923982

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory