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Pde11a Gene Detail
Summary
  • Symbol
    Pde11a
  • Name
    phosphodiesterase 11A
  • Synonyms
    6330414F14Rik, A630086N24Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:3036251
    NCBI Gene: 241489
  • Gene Overview
    MyGene.info: PDE11A
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr2:75989141-76338774 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      349634 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 44.80 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    PDE11A, phosphodiesterase 11A
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PDE11A, phosphodiesterase 11A
    Orthology source: HGNC, HomoloGene
  • Synonyms
    PPNAD2
  • Links
    NCBI Gene ID: 50940
    neXtProt AC: NX_Q9HCR9
    UniProt: Q9HCR9

  • Chr Location
    2q31.2; chr2:177623249-178108339 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human PDE11A associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele have enlarged lateral ventricles and exhibit abnormal behavior.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000015170 VEGA Gene Model | MGI Sequence Detail 349634 C57BL/6J ±  kb
    transcript OTTMUST00000035969 VEGA | MGI Sequence Detail 4189 Not Applicable  
    polypeptide OTTMUSP00000016155 VEGA | MGI Sequence Detail 933 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      3208 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 7
      Genomic 2
      cDNA 5

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1923982
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 5
      Gene Ontology 5
      Phenotypes 9
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:252096 Paul A, et al., Transcriptional Architecture of Synaptic Communication Delineates GABAergic Neuron Identity. Cell. 2017 Oct 19;171(3):522-539.e20

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    09/18/2018
    MGI 6.12
    The Jackson Laboratory