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Hfm1 Gene Detail
Summary
  • Symbol
    Hfm1
  • Name
    HFM1, ATP-dependent DNA helicase homolog
  • Synonyms
    A330009G12Rik, LOC381663, Mer3, Sec63d1
  • Feature Type
    protein coding gene
  • IDs
    MGI:3036246
    NCBI Gene: 330149
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:106988058-107074187 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 5, 51.43 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    485 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3036246
protein coding gene Chr5:106988058-107074427 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029832
protein coding gene Chr5:108822327-108911588 (-)
A/J MGP_AJ_G0029796
protein coding gene Chr5:104670396-104755773 (-)
AKR/J MGP_AKRJ_G0029741
protein coding gene Chr5:108061095-108153612 (-)
BALB/cJ MGP_BALBcJ_G0029808
protein coding gene Chr5:105810407-105898232 (-)
C3H/HeJ MGP_C3HHeJ_G0029530
protein coding gene Chr5:108508736-108596451 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030262
protein coding gene Chr5:113336732-113425175 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027496
protein coding gene Chr5:99738911-99828789 (-)
CAST/EiJ MGP_CASTEiJ_G0028944
protein coding gene Chr5:107411332-107503592 (-)
CBA/J MGP_CBAJ_G0029498
protein coding gene Chr5:117108939-117211925 (-)
DBA/2J MGP_DBA2J_G0029644
protein coding gene Chr5:104812283-104895279 (-)
FVB/NJ MGP_FVBNJ_G0029601
protein coding gene Chr5:103535672-103618798 (-)
LP/J MGP_LPJ_G0029732
protein coding gene Chr5:109412905-109507897 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029633
protein coding gene Chr5:122066158-122169168 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030296
protein coding gene Chr5:107604432-107691222 (-)
PWK/PhJ MGP_PWKPhJ_G0028657
protein coding gene Chr5:103602590-103687779 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028495
protein coding gene Chr5:105102477-105195587 (-)
WSB/EiJ MGP_WSBEiJ_G0029017
protein coding gene Chr5:107911860-107998642 (-)



Homology
more
  • Human Ortholog
    HFM1, helicase for meiosis 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HFM1, helicase for meiosis 1
  • Synonyms
    helicase, MER3, POF9, SEC63D1, Si-11, Si-11-6
  • Links
    NCBI Gene ID: 164045
    neXtProt AC: NX_A2PYH4
    UniProt: A2PYH4

  • Chr Location
    1p22.2; chr1:91260766-91408007 (-)  GRCh38

Human Diseases
more
  • Diseases
    1 with human HFM1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    22 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Meiosis ais disrupted in homozygotes and bothe sexes are sterile
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000043410 Ensembl Gene Model | MGI Sequence Detail 86130 C57BL/6J ±  kb
    transcript ENSMUST00000117588 Ensembl | MGI Sequence Detail 4870 Not Applicable  
    polypeptide ENSMUSP00000112590 Ensembl | MGI Sequence Detail 1434 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 4
      cDNA 4
    Other
    Accession IDs
    less
    MGI:2685892
    References
    more
    • Summaries
      All 32
      Developmental Gene Expression 1
      Gene Ontology 4
      Phenotypes 15
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:306271 Wang H, et al., Hfm1 participates in Golgi-associated spindle assembly and division in mouse oocyte meiosis. Cell Death Dis. 2020 Jun 30;11(6):490

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory