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Ralgapa2 Gene Detail
Summary
  • Symbol
    Ralgapa2
  • Name
    Ral GTPase activating protein, alpha subunit 2 (catalytic)
  • Synonyms
    A230067G21Rik, AS250, RGC2
  • Feature Type
    protein coding gene
  • IDs
    MGI:3036245
    NCBI Gene: 241694
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:146081799-146354264 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 2, 71.33 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2052 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3036245
protein coding gene Chr2:146079326-146354264 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026599
protein coding gene Chr2:150421215-150701600 (-)
A/J MGP_AJ_G0026563
protein coding gene Chr2:144319268-144593659 (-)
AKR/J MGP_AKRJ_G0026537
protein coding gene Chr2:148530141-148812433 (-)
BALB/cJ MGP_BALBcJ_G0026575
protein coding gene Chr2:144751779-145024753 (-)
C3H/HeJ MGP_C3HHeJ_G0026318
protein coding gene Chr2:148997144-149275458 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027020
protein coding gene Chr2:154856602-155142285 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024397
protein coding gene Chr2:138438537-138708358 (-)
CAST/EiJ MGP_CASTEiJ_G0025779
protein coding gene Chr2:149346512-149633061 (-)
CBA/J MGP_CBAJ_G0026298
protein coding gene Chr2:160471881-160774752 (-)
DBA/2J MGP_DBA2J_G0026432
protein coding gene Chr2:143621160-143893106 (-)
FVB/NJ MGP_FVBNJ_G0026396
protein coding gene Chr2:142154153-142426906 (-)
LP/J MGP_LPJ_G0026536
protein coding gene Chr2:150609611-150886560 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026416
protein coding gene Chr2:164662158-164959043 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027075
protein coding gene Chr2:148517345-148793699 (-)
PWK/PhJ MGP_PWKPhJ_G0025514
protein coding gene Chr2:143299969-143576666 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025315
protein coding gene Chr2:147491810-147767554 (-)
WSB/EiJ MGP_WSBEiJ_G0025852
protein coding gene Chr2:149446207-149728246 (-)



Homology
more
  • Human Ortholog
    RALGAPA2, Ral GTPase activating protein catalytic subunit alpha 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RALGAPA2, Ral GTPase activating protein catalytic subunit alpha 2
  • Synonyms
    AS250, bA287B20.1, C20orf74, dJ1049G11, dJ1049G11.4, p220
  • Links
    NCBI Gene ID: 57186
    neXtProt AC: NX_Q2PPJ7
    UniProt: Q2PPJ7

  • Chr Location
    chr20:20389530-20712644 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased incidence and severity of induced urothelial bladder tumors.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000037110 Ensembl Gene Model | MGI Sequence Detail 272466 C57BL/6J ±  kb
transcript ENSMUST00000228797 Ensembl | MGI Sequence Detail 8245 Not Applicable  
polypeptide ENSMUSP00000153734 Ensembl | MGI Sequence Detail 1957 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 73
    cDNA 73

    Microarray probesets 2
Other
Accession IDs
less
MGI:2681868
References
more
  • Summaries
    All 38
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 11
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:306836 Iida T, et al., Down-regulation of RalGTPase-Activating Protein Promotes Colitis-Associated Cancer via NLRP3 Inflammasome Activation. Cell Mol Gastroenterol Hepatol. 2020;9(2):277-293

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory