About   Help   FAQ
Ralgapa2
Gene Detail
 Symbol
Name
ID
Ralgapa2
Ral GTPase activating protein, alpha subunit 2 (catalytic)
MGI:3036245
Synonyms A230067G21Rik, AS250, RGC2
Feature Type protein coding gene
Genetic Map
Chromosome 2
71.33 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:146239879-146512026 bp, - strand
From VEGA annotation of GRCm38

  272148 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:28131  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Ralgapa2

Human
homologs
Human Homolog RALGAPA2, Ral GTPase activating protein, alpha subunit 2 (catalytic)
NCBI Gene ID 57186
neXtProt AC  NX_Q2PPJ7
Human Synonyms  AS250, bA287B20.1, C20orf74, dJ1049G11, dJ1049G11.4, p220
Human Chr (Location)  chr20:20389558-20712638 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(31) : Gene trapped(28) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit increased incidence and severity of induced urothelial bladder tumors.
 
Interactions
Ralgapa2 interacts with 505 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process activation of Ral GTPase activity, Ral protein signal transduction, ...
Component cytoplasm, extracellular space, ...
Function GTPase activator activity, protein heterodimerization activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (30)    Tissues (5)    Images (15)
Theiler Stages: 23
Assay TypeResults
RNA in situ 30
cDNA source data(70)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(70) cDNA(70)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000015703 (Evidence)
Ensembl Gene ModelENSMUSG00000037110 (Evidence)
Entrez Gene241694 (Evidence)
UniGene222310
DFCITC1589781, TC1594877, TC1598811, TC1602993, TC1603811, TC1604917, TC1618350, TC1625120, TC1628752, TC1655553
DoTSDT.101180187, DT.101184915, DT.101268679, DT.101353087, DT.101721057, DT.103568233, DT.40135974, DT.488836, DT.91368755
NIA Mouse Gene IndexU023449
Consensus CDS ProjectCCDS16831.2
International Mouse Knockout Project StatusRalgapa2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015703 VEGA Gene Model | MGI Sequence Detail 272148 C57BL/6J ±  kb
transcript OTTMUST00000037314 VEGA | MGI Sequence Detail 11030 Not Applicable 
polypeptide OTTMUSP00000016712 VEGA | MGI Sequence Detail 1910 Not Applicable 

For the selected sequences
All sequences(88) RefSeq(15) UniProt(4)
Polymorphisms SNPs within 2kb(2056 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016024 Armadillo-type fold
InterPro IPR000331 Rap GTPase activating proteins domain
Protein Ontology PR:000030854 ral GTPase-activating protein subunit alpha-2
References (Earliest) J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
(Latest) J:193368 Saito R, et al., Downregulation of Ral GTPase-activating protein promotes tumor invasion and metastasis of bladder cancer. Oncogene. 2013 Feb 14;32(7):894-902
All references(36)
Other
accession IDs
MGI:2681868

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/12/2014
MGI 5.19
The Jackson Laboratory