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Ralgapa2
Gene Detail
Symbol

Name
ID
Ralgapa2
Ral GTPase activating protein, alpha subunit 2 (catalytic)
MGI:3036245
Synonyms
A230067G21Rik, AS250, RGC2
Feature Type
protein coding gene
Genetic Map
Chromosome 2
71.33 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:146239879-146512026 bp, - strand
From VEGA annotation of GRCm38

  272148 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:28131  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Ralgapa2

Human
homologs
Human Homolog   RALGAPA2, Ral GTPase activating protein, alpha subunit 2 (catalytic)
NCBI Gene ID 57186
neXtProt AC  NX_Q2PPJ7
Human Synonyms  AS250, bA287B20.1, C20orf74, dJ1049G11, dJ1049G11.4, p220
Human Chr (Location)  chr20:20389558-20712638 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(31) : Gene trapped(28) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit increased incidence and severity of induced urothelial bladder tumors.
 
Interactions
Ralgapa2 interacts with 505 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process activation of GTPase activity, Ral protein signal transduction, ...
Component cytoplasm, extracellular space, ...
Function GTPase activator activity, protein heterodimerization activity
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (30)    Tissues (5)    Images (15)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 30
cDNA source data(71)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(71) cDNA(71)
Microarray probesets(2)
Other database
links
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015703 VEGA Gene Model | MGI Sequence Detail 272148 C57BL/6J ±  kb
transcript OTTMUST00000037314 VEGA | MGI Sequence Detail 11030 Not Applicable 
polypeptide OTTMUSP00000016712 VEGA | MGI Sequence Detail 1910 Not Applicable 

For the selected sequences
All sequences(93) RefSeq(16) UniProt(5)
Polymorphisms
SNPs within 2kb(2056 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016024 Armadillo-type fold
InterPro IPR000331 Rap GTPase activating proteins domain
Protein Ontology PR:000030854 ral GTPase-activating protein subunit alpha-2
References
(Earliest) J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
(Latest) J:193368 Saito R, et al., Downregulation of Ral GTPase-activating protein promotes tumor invasion and metastasis of bladder cancer. Oncogene. 2013 Feb 14;32(7):894-902
All references(35)
Other
accession IDs
MGI:2681868

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
02/25/2015
MGI 5.21
The Jackson Laboratory