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Nlrc4 Gene Detail
Summary
  • Symbol
    Nlrc4
  • Name
    NLR family, CARD domain containing 4
  • Synonyms
    9530011P19Rik, Card12, Ipaf
  • Feature Type
    protein coding gene
  • IDs
    MGI:3036243
    NCBI Gene: 268973
  • Gene Overview
    MyGene.info: NLRC4
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:74426295-74459108 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 45.64 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    240 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3036243
protein coding gene Chr17:74426255-74459145 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024029
protein coding gene Chr17:77060453-77102896 (-)
A/J MGP_AJ_G0023986
protein coding gene Chr17:74699770-74732468 (-)
AKR/J MGP_AKRJ_G0023955
protein coding gene Chr17:75773316-75814987 (-)
BALB/cJ MGP_BALBcJ_G0023988
protein coding gene Chr17:74605504-74638060 (-)
C3H/HeJ MGP_C3HHeJ_G0023752
protein coding gene Chr17:76702097-76735155 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024433
protein coding gene Chr17:79817584-79857202 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021877
protein coding gene Chr17:70336801-70370110 (-)
CAST/EiJ MGP_CASTEiJ_G0023232
protein coding gene Chr17:77200550-77238973 (-)
CBA/J MGP_CBAJ_G0023726
protein coding gene Chr17:83183626-83223890 (-)
DBA/2J MGP_DBA2J_G0023855
protein coding gene Chr17:73292743-73325449 (-)
FVB/NJ MGP_FVBNJ_G0023821
protein coding gene Chr17:72790978-72823191 (-)
LP/J MGP_LPJ_G0023938
protein coding gene Chr17:77822841-77864691 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023849
protein coding gene Chr17:82974395-83013298 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024477
protein coding gene Chr17:76249705-76288117 (-)
PWK/PhJ MGP_PWKPhJ_G0022978
protein coding gene Chr17:72666192-72701412 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022789
protein coding gene Chr17:72952138-72985563 (-)
WSB/EiJ MGP_WSBEiJ_G0023299
protein coding gene Chr17:77117306-77152279 (-)



Homology
more
  • Human Ortholog
    NLRC4, NLR family CARD domain containing 4
  • Vertebrate Orthologs
    7
  • Human Ortholog
    NLRC4, NLR family CARD domain containing 4
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AIFEC, CARD12, CLAN, CLAN1, CLANA, CLANB, CLANC, CLAND, CLR2.1, FCAS4, IPAF
  • Links
    NCBI Gene ID: 58484
    neXtProt AC: NX_Q9NPP4
    UniProt: Q9NPP4

  • Chr Location
    2p22.3; chr2:32224449-32265743 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Nlrc4 mouse models; 1 with human NLRC4 associations

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    21 phenotypes from 6 alleles in 5 genetic backgrounds
    4 phenotypes from multigenic genotypes
    150 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a null allele show lack of caspase-1 activation in macrophages infected with Legionella and Salmonella, and enhanced permissivity to Legionella replication. Homozygotes for another null allele fail to show caspase dependent cell death andIL-1beta secretion upon Salmonella infection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000039193 Ensembl Gene Model | MGI Sequence Detail 32814 C57BL/6J ±  kb
transcript ENSMUST00000052124 Ensembl | MGI Sequence Detail 4729 Not Applicable  
polypeptide ENSMUSP00000059637 Ensembl | MGI Sequence Detail 1024 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 9
    cDNA 9

    Microarray probesets 1
References
more
  • Summaries
    All 196
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 14
    Phenotypes 150
  • Earliest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
  • Latest
    J:262477 Karki R, et al., IRF8 Regulates Transcription of Naips for NLRC4 Inflammasome Activation. Cell. 2018 May 3;173(4):920-933.e13

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory