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Hdac4 Gene Detail
Summary
  • Symbol
    Hdac4
  • Name
    histone deacetylase 4
  • Synonyms
    4932408F19Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:3036234
    NCBI Gene: 208727
  • Gene Overview
    MyGene.info: HDAC4
Location & Maps
more
  • Sequence Map
    Chr1:91928779-92180341 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      251563 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    HDAC4, histone deacetylase 4
  • Vertebrate Orthologs
    9
  • Human Ortholog
    HDAC4, histone deacetylase 4
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AHO3, BDMR, HA6116, HD4, HDAC-4, HDACA, HDAC-A
  • Links
    NCBI Gene ID: 9759
    neXtProt AC: NX_P56524

  • Chr Location
    2q37.3; chr2:239048168-239401647 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    26 phenotypes from 4 alleles in 5 genetic backgrounds
    2 phenotypes from multigenic genotypes
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    120
  • Chemically induced (other)
    1
  • Gene trapped
    114
  • Radiation induced
    1
  • Targeted
    3
  • Transgenic
    1
  • Genomic Mutations
    2 involving Hdac4
  • Incidental Mutations
Mice homozygous for a gene trap allele exhibit increased thermal nociception threshold and seizures. Mice homozygous for a knock-out allele exhibit postnatal lethality, exencephaly, and abnormal skeleton morphology and physiology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000048554 VEGA Gene Model | MGI Sequence Detail 251563 C57BL/6J ±  kb
transcript OTTMUST00000124406 VEGA | MGI Sequence Detail 8100 Not Applicable  
polypeptide OTTMUSP00000067696 VEGA | MGI Sequence Detail 1076 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1387 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000008483 histone deacetylase 4
  • EC
  • InterPro Domains
    IPR017320 Histone deacetylase class II, eukaryotic
    IPR023801 Histone deacetylase domain
    IPR024643 Histone deacetylase, glutamine rich N-terminal domain
    IPR000286 Histone deacetylase superfamily
Molecular
Reagents
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  • All nucleic 11
    cDNA 10
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:3034516
References
more
  • Summaries
    All 91
    Developmental Gene Expression 16
    Gene Ontology 25
    Phenotypes 31
  • Earliest
    J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
  • Latest
    J:225455 Crow M, et al., HDAC4 is required for inflammation-associated thermal hypersensitivity. FASEB J. 2015 Aug;29(8):3370-8

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory