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Hdac4
Gene Detail
Symbol

Name
ID
Hdac4
histone deacetylase 4
MGI:3036234
Synonyms
4932408F19Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 1
46.24 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:91928779-92180341 bp, - strand
From VEGA annotation of GRCm38

  251563 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55946  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: HDAC4
Protein SuperFamily: histone deacetylase class II, eukaryotic type
Gene Tree: Hdac4

Human
homologs
HDAC4, histone deacetylase 4
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 9759
neXtProt AC: NX_P56524

Human Synonyms: AHO3, BDMR, HA6116, HD4, HDAC-4, HDACA, HDAC-A

Human Chr (Location): 2q37.3; chr2:239048168-239401647 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(117) : Gene trapped(114) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a gene trap allele exhibit increased thermal nociception threshold and seizures. Mice homozygous for a knock-out allele exhibit postnatal lethality, exencephaly, and abnormal skeleton morphology and physiology.
 
Interactions
Hdac4 interacts with 288 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (100 annotations)
Process chromatin modification, chromatin remodeling, ...
Component A band, actomyosin, ...
Function activating transcription factor binding, chromatin binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (15 records)
Data Summary: Results (99)    Tissues (16)    Images (21)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 63
RT-PCR 36
cDNA source data(10)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA HDAC4 ; Xenbase hdac4 ; ZFIN hdac4    NEW 
Molecular
reagents
All nucleic(11) cDNA(10) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000048554 (Evidence)
Ensembl Gene Model ENSMUSG00000026313 (Evidence)
Entrez Gene 208727 (Evidence)
DFCI TC1611020, TC1638018, TC1609771, TC1579334
NIA Mouse Gene Index U021595
EC 3.5.1.98
Consensus CDS Project CCDS48324.1
International Mouse Phenotyping Consortium Status Hdac4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000048554 VEGA Gene Model | MGI Sequence Detail 251563 C57BL/6J ±  kb
transcript OTTMUST00000124406 VEGA | MGI Sequence Detail 8100 Not Applicable 
polypeptide OTTMUSP00000067696 VEGA | MGI Sequence Detail 1076 Not Applicable 

For the selected sequences
All sequences(75) RefSeq(24) UniProt(4)
Polymorphisms
SNPs within 2kb(1392 from dbSNP Build 137)    SNPs within 2kb including multiple locations(1396)
Protein-related
information
ResourceIDDescription
InterPro IPR017320 Histone deacetylase class II, eukaryotic
InterPro IPR023801 Histone deacetylase domain
InterPro IPR024643 Histone deacetylase, glutamine rich N-terminal domain
InterPro IPR000286 Histone deacetylase superfamily
Protein Ontology PR:000008483 histone deacetylase 4
References
(Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:215793 Obri A, et al., HDAC4 integrates PTH and sympathetic signaling in osteoblasts. J Cell Biol. 2014 Jun 23;205(6):771-80
All references(87)
Other
accession IDs
MGI:3034516

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory