Hdac4
Gene Detail

Symbol Name ID

Hdac4 histone deacetylase 4 MGI:3036234

Synonyms

4932408F19Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 1

46.24 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr1:91932734-92148393 bp, - strand From NCBI annotation of GRCm38   215660 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:55946  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: histone deacetylase class II, eukaryotic type

Human homologs

Human Homolog		HDAC4, histone deacetylase 4
NCBI Gene ID		9759
neXtProt AC		NX_P56524
Human Synonyms		AHO3, BDMR, HA6116, HD4, HDAC-4, HDACA, HDAC-A
Human Chr (Location)		2q37.3; chr2:239969864-240322643 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human HDAC4

Alleles and phenotypes

All alleles(111) : Targeted(3) Gene trapped(108)
 

Mice homozygous for a gene trap allele exhibit increased thermal nociception threshold and seizures. Mice homozygous for a knock-out allele exhibit postnatal lethality, exencephaly, and abnormal skeleton morphology and physiology.

 

Gene Ontology (GO) classifications

All GO classifications: (93 annotations)

Process	chromatin modification, chromatin remodeling, ...
Component	A band, actomyosin, ...
Function	activating transcription factor binding, core promoter binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (12 records)
Data Summary: Results (99)    Tissues (16)    Images (21)
Theiler Stages: 2, 3, 23, 25

Assay Type	Results
RNA in situ	63
RT-PCR	36

cDNA source data(62)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(63) cDNA(62) Primer pair(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000073617 (Evidence), ENSMUSG00000026313 (Evidence)
Entrez Gene	208727 (Evidence)
UniGene	318567
DFCI	TC1579334, TC1609771, TC1611020, TC1638018
NIA Mouse Gene Index	U021595
EC	3.5.1.98
Consensus CDS Project	CCDS48324.1
International Mouse Knockout Project Status	Hdac4

Sequences

Length	Strain/Species
genomic	208727	NCBI Gene Model | MGI Sequence Detail	215660	C57BL/6J
transcript	NM_207225	RefSeq | MGI Sequence Detail	3960	C57BL/6
polypeptide	Q6NZM9	UniProt | EBI | MGI Sequence Detail	1076	Not Applicable

All sequences(30) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(1158 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017320	Histone deacetylase class II, eukaryotic
InterPro	IPR023801	Histone deacetylase domain
InterPro	IPR024643	Histone deacetylase, glutamine rich N-terminal domain
InterPro	IPR000286	Histone deacetylase superfamily
Protein Ontology	PR:000008483	histone deacetylase 4

Graphical View of Protein Domain Structure

References

(Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:193174 Sailaja BS, et al., Stress-induced epigenetic transcriptional memory of acetylcholinesterase by HDAC4. Proc Natl Acad Sci U S A. 2012 Dec 26;109(52):E3687-95
All references(76)

Other accession IDs

MGI:3034516