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Defb42 Gene Detail
Summary
  • Symbol
    Defb42
  • Name
    defensin beta 42
  • Feature Type
    protein coding gene
  • IDs
    MGI:3033850
    NCBI Gene: 619548
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr14:63046991-63048606 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 33.24 cM, cytoband C3
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    10 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3033850
protein coding gene Chr14:63046991-63058149 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021455
protein coding gene Chr14:57528872-57541066 (+)
A/J MGP_AJ_G0021414
protein coding gene Chr14:56237591-56249958 (+)
AKR/J MGP_AKRJ_G0021390
protein coding gene Chr14:58247342-58260638 (+)
BALB/cJ MGP_BALBcJ_G0021420
protein coding gene Chr14:56193418-56205125 (+)
C3H/HeJ MGP_C3HHeJ_G0021197
protein coding gene Chr14:57863019-57876801 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021859
protein coding gene Chr14:60276808-60291388 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019399
protein coding gene Chr14:54202550-54214395 (+)
CAST/EiJ MGP_CASTEiJ_G0020714
protein coding gene Chr14:54314026-54326064 (+)
CBA/J MGP_CBAJ_G0021164
protein coding gene Chr14:62060580-62074584 (+)
DBA/2J MGP_DBA2J_G0021287
protein coding gene Chr14:55893052-55904712 (+)
FVB/NJ MGP_FVBNJ_G0021266
protein coding gene Chr14:55313523-55324679 (+)
LP/J MGP_LPJ_G0021362
protein coding gene Chr14:58557898-58571560 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021295
protein coding gene Chr14:61338192-61352270 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021882
protein coding gene Chr14:57388333-57400190 (+)
PWK/PhJ MGP_PWKPhJ_G0020458
protein coding gene Chr14:52581747-52593395 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020291
protein coding gene Chr14:53368792-53380933 (+)
WSB/EiJ MGP_WSBEiJ_G0020767
protein coding gene Chr14:57707778-57719862 (+)



Homology
more
  • Human Ortholog
    DEFB136, defensin beta 136
  • Vertebrate Orthologs
    2
  • Human Ortholog
    DEFB136, defensin beta 136
    Orthology source: HGNC
  • Synonyms
    DEFB137
  • Links
    NCBI Gene ID: 613210
    neXtProt AC: NX_Q30KP8
    UniProt: Q30KP8

  • Chr Location
    8p23.1; chr8:11973937-11974599 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 619548 NCBI Gene Model | MGI Sequence Detail 1616 C57BL/6J ±  kb
transcript NM_001034910 RefSeq | MGI Sequence Detail 619 C57BL/6  
polypeptide Q8BVB5 UniProt | EBI | MGI Sequence Detail 75 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 6
    cDNA 6

    Microarray probesets 2
References
more
  • Summaries
    All 21
    Developmental Gene Expression 1
    Gene Ontology 2
    Phenotypes 2
  • Earliest
    J:100553 Jalkanen J, et al., Discovery and characterization of new epididymis-specific beta-defensins in mice. Biochim Biophys Acta. 2005 Jul 25;1730(1):22-30
  • Latest
    J:156769 Amid C, et al., Manual annotation and analysis of the defensin gene cluster in the C57BL/6J mouse reference genome. BMC Genomics. 2009;10:606

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory