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Mrgprb8 Gene Detail
Summary
  • Symbol
    Mrgprb8
  • Name
    MAS-related GPR, member B8
  • Synonyms
    MrgB8
  • Feature Type
    protein coding gene
  • IDs
    MGI:3033134
    NCBI Gene: 404240
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr7:48038274-48039396 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 31.11 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    42 from dbSNP Build 142
  • Strain Annotations
    16
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3033134
protein coding gene Chr7:48038274-48039396 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032289
protein coding gene Chr7:49018177-49019299 (+)
A/J MGP_AJ_G0032268
protein coding gene Chr7:48293167-48294289 (+)
AKR/J MGP_AKRJ_G0032204
protein coding gene Chr7:49460237-49461359 (+)
BALB/cJ MGP_BALBcJ_G0032280
protein coding gene Chr7:47956858-47957980 (+)
C3H/HeJ MGP_C3HHeJ_G0031993
protein coding gene Chr7:49813753-49814875 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032773
protein coding gene Chr7:51256094-51257216 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029780
protein coding gene Chr7:51478924-51480055 (+)
CAST/EiJ MGP_CASTEiJ_G0031321
protein coding gene Chr7:41242160-41243282 (+)
CBA/J MGP_CBAJ_G0031958
protein coding gene Chr7:53014409-53015531 (+)
DBA/2J MGP_DBA2J_G0032115
protein coding gene Chr7:47512429-47513551 (+)
FVB/NJ MGP_FVBNJ_G0032069
protein coding gene Chr7:47467879-47469001 (+)
LP/J MGP_LPJ_G0032196
protein coding gene Chr7:49953960-49955082 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032106
protein coding gene Chr7:52141641-52143423 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032790
protein coding gene Chr7:48436091-48437213 (+)
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0030882
protein coding gene Chr7:36585152-36586274 (+)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    MRGPRX1, MAS related GPR family member X1
  • Vertebrate Orthologs
    6
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MRGPRX1, MAS related GPR family member X1
  • Synonyms
    GPCR, MGRG2, MRGX1, SNSR4
  • Links
    NCBI Gene ID: 259249
    neXtProt AC: NX_Q96LB2
    UniProt: Q96LB2

  • Chr Location
    11p15.1,11; chr11:18933813-18935002 (-)  GRCh38.p7

  • Human Ortholog
    MRGPRX2, MAS related GPR family member X2
  • Synonyms
    MGRG3, MRGX2
  • Links
    NCBI Gene ID: 117194
    neXtProt AC: NX_Q96LB1
    UniProt: Q96LB1

  • Chr Location
    11p15.1; chr11:19054455-19060681 (-)  GRCh38.p7

  • Human Ortholog
    MRGPRX3, MAS related GPR family member X3
  • Synonyms
    GPCR, MRGX3, SNSR1, SNSR2
  • Links
    NCBI Gene ID: 117195
    neXtProt AC: NX_Q96LB0
    UniProt: Q96LB0

  • Chr Location
    11p15.1; chr11:18120955-18138480 (+)  GRCh38.p7

  • Human Ortholog
    MRGPRX4, MAS related GPR family member X4
  • Synonyms
    GPCR, MRGX4, SNSR6
  • Links
    NCBI Gene ID: 117196
    neXtProt AC: NX_Q96LA9
    UniProt: Q96LA9

  • Chr Location
    11p15.1; chr11:18172837-18174280 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 404240 NCBI Gene Model | MGI Sequence Detail 1123 C57BL/6J ±  kb
transcript NM_207539 RefSeq | MGI Sequence Detail 1123 Not Specified  
polypeptide Q7TN51 UniProt | EBI | MGI Sequence Detail 330 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 3
    cDNA 3

    Microarray probesets 1
References
more
  • Summaries
    All 18
    Gene Ontology 4
  • Earliest
    J:71586 Dong X, et al., A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons. Cell. 2001 Sep 7;106(5):619-32
  • Latest
    J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
10/12/2021
MGI 6.17
The Jackson Laboratory