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Mrgprb4 Gene Detail
Summary
  • Symbol
    Mrgprb4
  • Name
    MAS-related GPR, member B4
  • Synonyms
    MrgB4
  • Feature Type
    protein coding gene
  • IDs
    MGI:3033119
    NCBI Gene: 233230
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr7:47847961-47848926 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 31.11 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    92 from dbSNP Build 142
  • Strain Annotations
    14
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3033119
protein coding gene Chr7:47847818-47849036 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032288
protein coding gene Chr7:48790485-48791703 (-)
A/J MGP_AJ_G0032267
protein coding gene Chr7:48053642-48054860 (-)
AKR/J MGP_AKRJ_G0032203
protein coding gene Chr7:49245293-49246511 (-)
BALB/cJ MGP_BALBcJ_G0032279
protein coding gene Chr7:47773364-47774582 (-)
C3H/HeJ MGP_C3HHeJ_G0031992
protein coding gene Chr7:49590794-49592012 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032772
protein coding gene Chr7:51063305-51064523 (-)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0031320
protein coding gene Chr7:41066078-41067295 (-)
CBA/J MGP_CBAJ_G0031957
protein coding gene Chr7:52760263-52761481 (-)
DBA/2J MGP_DBA2J_G0032114
protein coding gene Chr7:47329689-47330907 (-)
FVB/NJ MGP_FVBNJ_G0032068
protein coding gene Chr7:47332214-47334616 (-)
LP/J MGP_LPJ_G0032194
protein coding gene Chr7:49732215-49735748 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032105
protein coding gene Chr7:51978987-51981876 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032789
protein coding gene Chr7:48255887-48257105 (-)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    MRGPRX1, MAS related GPR family member X1
  • Vertebrate Orthologs
    6
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MRGPRX1, MAS related GPR family member X1
  • Synonyms
    GPCR, MGRG2, MRGX1, SNSR4
  • Links
    NCBI Gene ID: 259249
    neXtProt AC: NX_Q96LB2
    UniProt: Q96LB2

  • Chr Location
    11p15.1,11; chr11:18933813-18935002 (-)  GRCh38.p7

  • Human Ortholog
    MRGPRX2, MAS related GPR family member X2
  • Synonyms
    MGRG3, MRGX2
  • Links
    NCBI Gene ID: 117194
    neXtProt AC: NX_Q96LB1
    UniProt: Q96LB1

  • Chr Location
    11p15.1; chr11:19054455-19060681 (-)  GRCh38.p7

  • Human Ortholog
    MRGPRX3, MAS related GPR family member X3
  • Synonyms
    GPCR, MRGX3, SNSR1, SNSR2
  • Links
    NCBI Gene ID: 117195
    neXtProt AC: NX_Q96LB0
    UniProt: Q96LB0

  • Chr Location
    11p15.1; chr11:18120955-18138480 (+)  GRCh38.p7

  • Human Ortholog
    MRGPRX4, MAS related GPR family member X4
  • Synonyms
    GPCR, MRGX4, SNSR6
  • Links
    NCBI Gene ID: 117196
    neXtProt AC: NX_Q96LA9
    UniProt: Q96LA9

  • Chr Location
    11p15.1; chr11:18172837-18174280 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    19 phenotype references
Mice homozygous for a null allele are viable, fertile and overtly normal with no apparent alterations in the pattern of axonal innervation of the epidermis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 233230 NCBI Gene Model | MGI Sequence Detail 966 C57BL/6J ±  kb
transcript NM_205795 RefSeq | MGI Sequence Detail 966 C57BL/6  
polypeptide Q91ZC0 UniProt | EBI | MGI Sequence Detail 321 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • InterPro Domains
    IPR017452 GPCR, rhodopsin-like, 7TM
    IPR000276 G protein-coupled receptor, rhodopsin-like
    IPR026234 Mas-related G protein-coupled receptor family
Molecular
Reagents
less
  • All nucleic 5
    cDNA 4
    Other 1

    Microarray probesets 1
References
more
  • Summaries
    All 44
    Developmental Gene Expression 8
    Gene Ontology 4
    Phenotypes 19
  • Earliest
    J:71586 Dong X, et al., A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons. Cell. 2001 Sep 7;106(5):619-32
  • Latest
    J:311626 Grundy L, et al., Activation of MrgprA3 and MrgprC11 on Bladder-Innervating Afferents Induces Peripheral and Central Hypersensitivity to Bladder Distension. J Neurosci. 2021 Apr 28;41(17):3900-3916

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
11/16/2021
MGI 6.17
The Jackson Laboratory