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Card6 Gene Detail
Summary
  • Symbol
    Card6
  • Name
    caspase recruitment domain family, member 6
  • Feature Type
    protein coding gene
  • IDs
    MGI:3032959
    NCBI Gene: 239319
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:5125463-5138021 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 1.99 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    378 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3032959
 protein coding gene Chr15:5125463-5146762 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021690
 protein coding gene Chr15:2006141-2009453 (-)
A/J MGP_AJ_G0021650
 protein coding gene Chr15:2009694-2024223 (-)
AKR/J MGP_AKRJ_G0021628
 protein coding gene Chr15:1977655-1990550 (-)
BALB/cJ MGP_BALBcJ_G0021657
 protein coding gene Chr15:1934235-1948388 (-)
C3H/HeJ MGP_C3HHeJ_G0021433
 protein coding gene Chr15:2006795-2019295 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022096
 protein coding gene Chr15:2085629-2098670 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019634
 protein coding gene Chr15:1751979-1764232 (-)
CAST/EiJ MGP_CASTEiJ_G0020950
 protein coding gene Chr15:1994032-2008410 (-)
CBA/J MGP_CBAJ_G0021402
 protein coding gene Chr15:2122013-2135107 (-)
DBA/2J MGP_DBA2J_G0021526
 protein coding gene Chr15:1945393-1957076 (-)
FVB/NJ MGP_FVBNJ_G0021504
 protein coding gene Chr15:1881864-1895485 (-)
LP/J MGP_LPJ_G0021594
 protein coding gene Chr15:1940406-1943764 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021530
 protein coding gene Chr15:2240009-2255612 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022119
 protein coding gene Chr15:1981549-1997282 (-)
PWK/PhJ MGP_PWKPhJ_G0020693
 protein coding gene Chr15:1956354-1969090 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020531
 protein coding gene Chr15:1957384-1969544 (-)
WSB/EiJ MGP_WSBEiJ_G0021005
 protein coding gene Chr15:1922181-1937798 (-)



Homology
more
  • Human Ortholog
    CARD6, caspase recruitment domain family member 6
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CARD6, caspase recruitment domain family member 6
  • Synonyms
    CINCIN1
  • Links
    NCBI Gene ID: 84674
    UniProt: Q9BX69

  • Chr Location
    5p13.1; chr5:40841308-40860175 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    6 phenotype references
Knockout mice are viable and grossly normal with no deficits in thymocytes, granulocytes, macrophages, NK cells or T- and B-cell subsets. Various signaling pathways mediating innate and adaptive immune responses appear unaltered. Mice are normally resistant to infection by a wide range of pathogens.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    2
  • GO References
    1
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    744
  • Tissues
    5
  • cDNA Data
    22
  • Literature Summary
    1
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000041849 Ensembl Gene Model | MGI Sequence Detail 12559 C57BL/6J ±  kb
transcript ENSMUST00000118365 Ensembl | MGI Sequence Detail 5995 Not Applicable  
polypeptide ENSMUSP00000112833 Ensembl | MGI Sequence Detail 1175 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • InterPro Domains
    IPR052685 Apoptosis Repressor CARD Domain-Containing Protein
    IPR001315 CARD domain
    IPR011029 Death-like domain superfamily
  • GlyGen
    E9PWH2 1 site
Molecular
Reagents
less
  • All nucleic 22
    cDNA 22

    Microarray probesets 2
References
more
  • Summaries
    All 25
    Developmental Gene Expression 1
    Gene Ontology 1
    Phenotypes 6
  • Earliest
    J:85109 Stehlik C, et al., CARD6 is a modulator of NF-kappa B activation by Nod1- and Cardiak-mediated pathways. J Biol Chem. 2003 Aug 22;278(34):31941-9
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory