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Med13 Gene Detail
Summary
  • Symbol
    Med13
  • Name
    mediator complex subunit 13
  • Synonyms
    1110067M05Rik, Thrap1, Trap240
  • Feature Type
    protein coding gene
  • IDs
    MGI:3029632
    NCBI Gene: 327987
  • Gene Overview
    MyGene.info: MED13
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr11:86267033-86357602 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      90570 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 51.75 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    MED13, mediator complex subunit 13
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MED13, mediator complex subunit 13
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ARC250, DRIP250, HSPC221, THRAP1, TRAP240
  • Links
    NCBI Gene ID: 9969
    neXtProt AC: NX_Q9UHV7
    UniProt: Q9UHV7

  • Chr Location
    17q23.2; chr17:61942605-62065983 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 21067
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: MED13
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 1 allele in 1 genetic background
    17 phenotypes from multigenic genotypes
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a conditional allele exhibited in the heart exhibit increased susceptibility to obesity and worsened glucose intolerance when fed a high fat diet.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000001199 VEGA Gene Model | MGI Sequence Detail 90570 C57BL/6J ±  kb
    transcript OTTMUST00000002386 VEGA | MGI Sequence Detail 10546 Not Applicable  
    polypeptide OTTMUSP00000001175 VEGA | MGI Sequence Detail 2171 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      275 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000010284 mediator of RNA polymerase II transcription subunit 13
    • InterPro Domains
      IPR009401 Mediator complex, subunit Med13
      IPR021643 Mediator complex, subunit Med13, N-terminal, metazoa/fungi
    Molecular
    Reagents
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    • All nucleic 102
      cDNA 101
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1916101
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 3
      Gene Ontology 9
      Phenotypes 20
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:239012 Aranda-Orgilles B, et al., MED12 Regulates HSC-Specific Enhancers Independently of Mediator Kinase Activity to Control Hematopoiesis. Cell Stem Cell. 2016 Dec 01;19(6):784-799

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    Funding Information
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory