About   Help   FAQ
Med13 Gene Detail
Summary
  • Symbol
    Med13
  • Name
    mediator complex subunit 13
  • Synonyms
    1110067M05Rik, Thrap1, Trap240
  • Feature Type
    protein coding gene
  • IDs
    MGI:3029632
    NCBI Gene: 327987
  • Gene Overview
    MyGene.info: MED13
Location & Maps
more
  • Sequence Map
    Chr11:86267033-86357602 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      90570 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    MED13, mediator complex subunit 13
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MED13, mediator complex subunit 13
    Orthology source: HomoloGene
  • Synonyms
    ARC250, DRIP250, HSPC221, THRAP1, TRAP240
  • Links
    NCBI Gene ID: 9969
    neXtProt AC: NX_Q9UHV7

  • Chr Location
    17q23.2; chr17:61942605-62065311 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 21067
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: MED13
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 1 allele in 1 genetic background
    17 phenotypes from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    18
  • Chemically induced (other)
    1
  • Gene trapped
    12
  • Targeted
    4
  • Transgenic
    1
  • Genomic Mutations
    2 involving Med13
  • Incidental Mutations
Mice homozygous for a conditional allele exhibited in the heart exhibit increased susceptibility to obesity and worsened glucose intolerance when fed a high fat diet.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001199 VEGA Gene Model | MGI Sequence Detail 90570 C57BL/6J ±  kb
transcript OTTMUST00000002386 VEGA | MGI Sequence Detail 10546 Not Applicable  
polypeptide OTTMUSP00000001175 VEGA | MGI Sequence Detail 2171 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    275 from dbSNP Build 142
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000010284 mediator of RNA polymerase II transcription subunit 13
  • InterPro Domains
    IPR009401 Mediator complex, subunit Med13
    IPR021643 Mediator complex, subunit Med13, N-terminal, metazoa/fungi
Molecular
Reagents
less
  • All nucleic 103
    cDNA 101
    Primer pair 1
    Other 1

    Microarray probesets 5
Other
Accession IDs
less
MGI:1916101
References
more
  • Summaries
    All 42
    Developmental Gene Expression 3
    Gene Ontology 9
    Phenotypes 17
  • Earliest
    J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
  • Latest
    J:186193 Grueter CE, et al., A cardiac microRNA governs systemic energy homeostasis by regulation of MED13. Cell. 2012 Apr 27;149(3):671-83

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/17/2016
MGI 6.03
The Jackson Laboratory