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Brwd3
Gene Detail
Symbol

Name
ID
Brwd3
bromodomain and WD repeat domain containing 3
MGI:3029414
Synonyms
Brodl, D030064D06Rik, LOC236955
Feature Type
protein coding gene
Genetic Map
Chromosome X
47.88 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
ChrX:108737016-108834372 bp, - strand
From VEGA annotation of GRCm38

  97357 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:18736  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: BRWD3
Gene Tree: Brwd3

Human
homologs
BRWD3, bromodomain and WD repeat domain containing 3
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 254065
neXtProt AC: NX_Q6RI45

Human Synonyms: BRODL, MRX93

Human Chr (Location): Xq21.1; chrX:80669488-80809734 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human BRWD3

Mutations,
alleles, and
phenotypes
All mutations/alleles(17) : Gene trapped(14) Targeted(3)
Incidental mutations (data from APF , CvDC )
 
Male chimeras hemizygous for a gene trapped allele exhibit short tail buds, microcephaly and, in some cases, embryonic growth retardation.
 
Phenotype Images(6)
Interactions
Brwd3 interacts with 560 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process cytoskeleton organization, regulation of cell shape, ...
Component nucleus
Function molecular_function
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(10)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase brwd3    NEW 
Molecular
reagents
All nucleic(12) cDNA(12)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000018333 (Evidence)
Ensembl Gene Model ENSMUSG00000063663 (Evidence)
Entrez Gene 382236 (Evidence)
DFCI TC1643021, TC1606367, TC1598123, TC1588193
Consensus CDS Project CCDS41100.1
International Mouse Phenotyping Consortium Status Brwd3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018333 VEGA Gene Model | MGI Sequence Detail 97357 C57BL/6J ±  kb
transcript OTTMUST00000044266 VEGA | MGI Sequence Detail 11619 Not Applicable 
polypeptide OTTMUSP00000019897 VEGA | MGI Sequence Detail 1799 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(311 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001487 Bromodomain
InterPro IPR001680 WD40 repeat
InterPro IPR019775 WD40 repeat, conserved site
InterPro IPR017986 WD40-repeat-containing domain
InterPro IPR015943 WD40/YVTN repeat-like-containing domain
Protein Ontology PR:000029303 bromodomain and WD repeat-containing protein 3
References
(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:204566 Gendrel AV, et al., Epigenetic functions of smchd1 repress gene clusters on the inactive X chromosome and on autosomes. Mol Cell Biol. 2013 Aug;33(16):3150-65
All references(32)
Other
accession IDs
MGI:2443903, MGI:2685442

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory