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Brwd3 Gene Detail
Summary
  • Symbol
    Brwd3
  • Name
    bromodomain and WD repeat domain containing 3
  • Synonyms
    Brodl, D030064D06Rik, LOC236955
  • Feature Type
    protein coding gene
  • IDs
    MGI:3029414
    NCBI Gene: 382236
  • Gene Overview
    MyGene.info: BRWD3
Location & Maps
more
  • Sequence Map
    ChrX:108737016-108834372 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      97357 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome X, 47.88 cM
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    BRWD3, bromodomain and WD repeat domain containing 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    BRWD3, bromodomain and WD repeat domain containing 3
    Orthology source: HomoloGene
  • Synonyms
    BRODL, MRX93
  • Links
    NCBI Gene ID: 254065
    neXtProt AC: NX_Q6RI45

  • Chr Location
    Xq21.1; chrX:80669488-80809734 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human BRWD3 associations

Human Disease Mouse Models
       Mental Retardation, X-Linked 93; MRX93   OMIM: 300659
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    6 images
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    17
  • Gene trapped
    14
  • Targeted
    3
  • Incidental Mutations
    APF , CvDC
Male chimeras hemizygous for a gene trapped allele exhibit short tail buds, microcephaly and, in some cases, embryonic growth retardation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018333 VEGA Gene Model | MGI Sequence Detail 97357 C57BL/6J ±  kb
transcript OTTMUST00000044266 VEGA | MGI Sequence Detail 11619 Not Applicable  
polypeptide OTTMUSP00000019897 VEGA | MGI Sequence Detail 1799 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    311 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 12
    cDNA 12

    Microarray probesets 2
Other
Accession IDs
less
MGI:2443903, MGI:2685442
References
more
  • Summaries
    All 31
    Developmental Gene Expression 1
    Gene Ontology 2
    Phenotypes 10
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:204566 Gendrel AV, et al., Epigenetic functions of smchd1 repress gene clusters on the inactive X chromosome and on autosomes. Mol Cell Biol. 2013 Aug;33(16):3150-65

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory