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Zfp281 Gene Detail
Summary
  • Symbol
    Zfp281
  • Name
    zinc finger protein 281
  • Synonyms
    MGC:70044, MGC:7737
  • Feature Type
    protein coding gene
  • IDs
    MGI:3029290
    NCBI Gene: 226442
  • Gene Overview
    MyGene.info: ZNF281
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:136624901-136630053 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 59.93 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    183 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3029290
protein coding gene Chr1:136624901-136630391 (.)
129S1/SvImJ MGP_129S1SvImJ_G0016543
protein coding gene Chr1:140482922-140488074 (+)
A/J MGP_AJ_G0016526
protein coding gene Chr1:135136032-135141184 (+)
AKR/J MGP_AKRJ_G0016491
protein coding gene Chr1:139164333-139169485 (+)
BALB/cJ MGP_BALBcJ_G0016486
protein coding gene Chr1:135479094-135484246 (+)
C3H/HeJ MGP_C3HHeJ_G0016312
protein coding gene Chr1:139260031-139265183 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016947
protein coding gene Chr1:145482829-145487981 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014658
protein coding gene Chr1:128247357-128252492 (+)
CAST/EiJ MGP_CASTEiJ_G0015892
protein coding gene Chr1:138372127-138377283 (+)
CBA/J MGP_CBAJ_G0016285
protein coding gene Chr1:150519394-150524546 (+)
DBA/2J MGP_DBA2J_G0016391
protein coding gene Chr1:134132062-134137224 (+)
FVB/NJ MGP_FVBNJ_G0016390
protein coding gene Chr1:132783138-132788290 (+)
LP/J MGP_LPJ_G0016462
protein coding gene Chr1:141682650-141687802 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016415
protein coding gene Chr1:156163362-156168514 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016983
protein coding gene Chr1:138927711-138932863 (+)
PWK/PhJ MGP_PWKPhJ_G0015678
protein coding gene Chr1:133185405-133190526 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015465
protein coding gene Chr1:137918248-137923600 (+)
WSB/EiJ MGP_WSBEiJ_G0015955
protein coding gene Chr1:138966288-138971440 (+)



Homology
more
  • Human Ortholog
    ZNF281, zinc finger protein 281
  • Vertebrate Orthologs
    11
  • Human Ortholog
    ZNF281, zinc finger protein 281
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ZBP-99, ZNP-99
  • Links
    NCBI Gene ID: 23528
    neXtProt AC: NX_Q9Y2X9
    UniProt: Q9Y2X9

  • Chr Location
    1q32.1; chr1:200404947-200483604 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 8270
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ZNF281
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    2
  • Gene trapped
    2
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    3 involving Zfp281
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
Mice homozygous for a knock-out allele exhibit embryonic lethality between E7.5 and E8.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000041483 Ensembl Gene Model | MGI Sequence Detail 5153 C57BL/6J ±  kb
transcript ENSMUST00000047734 Ensembl | MGI Sequence Detail 4933 Not Applicable  
polypeptide ENSMUSP00000039003 Ensembl | MGI Sequence Detail 893 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 10
    cDNA 10

    Microarray probesets 4
References
more
  • Summaries
    All 44
    Developmental Gene Expression 7
    Gene Ontology 9
    Phenotypes 10
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:263854 Pieraccioli M, et al., ZNF281 inhibits neuronal differentiation and is a prognostic marker for neuroblastoma. Proc Natl Acad Sci U S A. 2018 Jul 10;115(28):7356-7361

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory