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Rasgrp3
Gene Detail
 Symbol
Name
ID
Rasgrp3
RAS, guanyl releasing protein 3
MGI:3028579
Synonyms LOC240168, MGC:74365
Feature Type protein coding gene
Genetic Map
Chromosome 17
46.55 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr17:75435905-75529043 bp, + strand
From Ensembl annotation of GRCm38

  93139 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:15019  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Rasgrp3

Human
homologs
Human Homolog RASGRP3, RAS guanyl releasing protein 3 (calcium and DAG-regulated)
NCBI Gene ID 25780
neXtProt AC  NX_Q8IV61
Human Synonyms  GRP3
Human Chr (Location)  2p25.1-p24.1; chr2:33436349-33564731 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant mice are viable and fertile with no obvious abnormalities in the kidneys or vasculature.
 
Interactions
Rasgrp3 interacts with 295 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process positive regulation of Rap GTPase activity, positive regulation of Ras GTPase activity, ...
Component cytoplasm, guanyl-nucleotide exchange factor complex, ...
Function guanyl-nucleotide exchange factor activity, kinase binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (6)    Tissues (3)    Images (4)
Theiler Stages: 21, 23, 25
Assay TypeResults
RNA in situ 4
RT-PCR 2
cDNA source data(5)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(6) cDNA(5) Primer pair(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000071042 (Evidence)
Entrez Gene240168 (Evidence)
DFCITC1579999, TC1641054
DoTSDT.101271331
NIA Mouse Gene IndexU018229
Consensus CDS ProjectCCDS37695.1
International Mouse Knockout Project StatusRasgrp3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000071042 Ensembl Gene Model | MGI Sequence Detail 93139 C57BL/6J ±  kb
transcript ENSMUST00000164192 Ensembl | MGI Sequence Detail 4665 Not Applicable 
polypeptide ENSMUSP00000129393 Ensembl | MGI Sequence Detail 691 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(10) UniProt(3)
Polymorphisms SNPs within 2kb(707 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR020454 Diacylglycerol/phorbol-ester binding
InterPro IPR018247 EF-Hand 1, calcium-binding site
InterPro IPR002048 EF-hand domain
InterPro IPR011992 EF-hand-like domain
InterPro IPR001895 Guanine-nucleotide dissociation stimulator CDC25
InterPro IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding
InterPro IPR023578 Ras guanine nucleotide exchange factor, domain
InterPro IPR000651 Ras-like guanine nucleotide exchange factor, N-terminal
Protein Ontology PR:000013760 ras guanyl-releasing protein 3
References (Earliest) J:94466 Aiba Y, et al., Activation of RasGRP3 by phosphorylation of Thr-133 is required for B cell receptor-mediated Ras activation. Proc Natl Acad Sci U S A. 2004 Nov 23;101(47):16612-7
(Latest) J:195716 Golec DP, et al., RasGRP1, but not RasGRP3, is required for efficient thymic beta-selection and ERK activation downstream of CXCR4. PLoS One. 2013;8(1):e53300
All references(34)
Other
accession IDs
MGI:2685173

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory