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Rasgrp3
Gene Detail
Symbol

Name
ID
Rasgrp3
RAS, guanyl releasing protein 3
MGI:3028579
Synonyms
LOC240168, MGC:74365
Feature Type
protein coding gene
Genetic Map
Chromosome 17
46.55 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr17:75435905-75529043 bp, + strand
From Ensembl annotation of GRCm38

  93139 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:15019  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: RASGRP3
Gene Tree: Rasgrp3

Human
homologs
RASGRP3, RAS guanyl releasing protein 3 (calcium and DAG-regulated)
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 25780
neXtProt AC: NX_Q8IV61

Human Synonyms: GRP3

Human Chr (Location): 2p25.1-p24.1; chr2:33436349-33564731 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mutant mice are viable and fertile with no obvious abnormalities in the kidneys or vasculature.
 
Interactions
Rasgrp3 interacts with 294 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process positive regulation of GTPase activity, Ras protein signal transduction, ...
Component cytoplasm, guanyl-nucleotide exchange factor complex, ...
Function GTPase activator activity, kinase binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (6)    Tissues (3)    Images (4)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 4
RT-PCR 2
cDNA source data(5)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase rasgrp3 ; ZFIN rasgrp3    NEW 
Molecular
reagents
All nucleic(6) cDNA(5) Primer pair(1)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000071042 (Evidence)
Entrez Gene 240168 (Evidence)
DFCI TC1579999, TC1641054
DoTS DT.101271331
NIA Mouse Gene Index U018229
Consensus CDS Project CCDS37695.1
International Mouse Phenotyping Consortium Status Rasgrp3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000071042 Ensembl Gene Model | MGI Sequence Detail 93139 C57BL/6J ±  kb
transcript ENSMUST00000164192 Ensembl | MGI Sequence Detail 4665 Not Applicable 
polypeptide ENSMUSP00000129393 Ensembl | MGI Sequence Detail 691 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(10) UniProt(3)
Polymorphisms
SNPs within 2kb(707 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR020454 Diacylglycerol/phorbol-ester binding
InterPro IPR018247 EF-Hand 1, calcium-binding site
InterPro IPR002048 EF-hand domain
InterPro IPR011992 EF-hand domain pair
InterPro IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
InterPro IPR023578 Ras guanine nucleotide exchange factor domain
InterPro IPR001895 Ras guanine-nucleotide exchange factors catalytic domain
InterPro IPR029645 Ras guanyl-releasing protein 3
InterPro IPR000651 Ras-like guanine nucleotide exchange factor, N-terminal
Protein Ontology PR:000013760 ras guanyl-releasing protein 3
References
(Earliest) J:94466 Aiba Y, et al., Activation of RasGRP3 by phosphorylation of Thr-133 is required for B cell receptor-mediated Ras activation. Proc Natl Acad Sci U S A. 2004 Nov 23;101(47):16612-7
(Latest) J:195716 Golec DP, et al., RasGRP1, but not RasGRP3, is required for efficient thymic beta-selection and ERK activation downstream of CXCR4. PLoS One. 2013;8(1):e53300
All references(31)
Other
accession IDs
MGI:2685173

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory