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Rasgrp3 Gene Detail
Summary
  • Symbol
    Rasgrp3
  • Name
    RAS, guanyl releasing protein 3
  • Synonyms
    LOC240168, MGC:74365
  • Feature Type
    protein coding gene
  • IDs
    MGI:3028579
    NCBI Gene: 240168
  • Gene Overview
    MyGene.info: RASGRP3
Location & Maps
more
  • Sequence Map
    Chr17:75435905-75529043 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      93139 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 46.55 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    RASGRP3, RAS guanyl releasing protein 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RASGRP3, RAS guanyl releasing protein 3
    Orthology source: HomoloGene
  • Synonyms
    GRP3
  • Links
    NCBI Gene ID: 25780
    neXtProt AC: NX_Q8IV61

  • Chr Location
    2p25.1-p24.1; chr2:33436349-33564731 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice are viable and fertile with no obvious abnormalities in the kidneys or vasculature.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000071042 Ensembl Gene Model | MGI Sequence Detail 93139 C57BL/6J ±  kb
transcript ENSMUST00000164192 Ensembl | MGI Sequence Detail 4665 Not Applicable  
polypeptide ENSMUSP00000129393 Ensembl | MGI Sequence Detail 691 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    705 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • InterPro Domains
    IPR020454 Diacylglycerol/phorbol-ester binding
    IPR018247 EF-Hand 1, calcium-binding site
    IPR002048 EF-hand domain
    IPR011992 EF-hand domain pair
    IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
    IPR023578 Ras guanine nucleotide exchange factor domain
    IPR001895 Ras guanine-nucleotide exchange factors catalytic domain
    IPR029645 Ras guanyl-releasing protein 3
    IPR000651 Ras-like guanine nucleotide exchange factor, N-terminal
Molecular
Reagents
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  • All nucleic 6
    cDNA 5
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
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MGI:2685173
References
more
  • Summaries
    All 27
    Developmental Gene Expression 4
    Gene Ontology 3
    Phenotypes 7
  • Earliest
    J:94466 Aiba Y, et al., Activation of RasGRP3 by phosphorylation of Thr-133 is required for B cell receptor-mediated Ras activation. Proc Natl Acad Sci U S A. 2004 Nov 23;101(47):16612-7
  • Latest
    J:195716 Golec DP, et al., RasGRP1, but not RasGRP3, is required for efficient thymic beta-selection and ERK activation downstream of CXCR4. PLoS One. 2013;8(1):e53300

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory