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Rasgrp3 Gene Detail
Summary
  • Symbol
    Rasgrp3
  • Name
    RAS, guanyl releasing protein 3
  • Synonyms
    LOC240168, MGC:74365
  • Feature Type
    protein coding gene
  • IDs
    MGI:3028579
    NCBI Gene: 240168
  • Gene Overview
    MyGene.info: RASGRP3
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:75435905-75529043 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 46.55 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    705 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3028579
protein coding gene Chr17:75435870-75529054 (.)
129S1/SvImJ MGP_129S1SvImJ_G0024034
protein coding gene Chr17:78143797-78243200 (+)
A/J MGP_AJ_G0023991
protein coding gene Chr17:75704664-75802928 (+)
AKR/J MGP_AKRJ_G0023960
protein coding gene Chr17:76822066-76920750 (+)
BALB/cJ MGP_BALBcJ_G0023993
protein coding gene Chr17:75611034-75707095 (+)
C3H/HeJ MGP_C3HHeJ_G0023757
protein coding gene Chr17:77731804-77833545 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024438
protein coding gene Chr17:80934999-81042472 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021882
protein coding gene Chr17:71312754-71408082 (+)
CAST/EiJ MGP_CASTEiJ_G0023237
protein coding gene Chr17:78272289-78373129 (+)
CBA/J MGP_CBAJ_G0023731
protein coding gene Chr17:84331716-84423266 (+)
DBA/2J MGP_DBA2J_G0023860
protein coding gene Chr17:74275890-74370882 (+)
FVB/NJ MGP_FVBNJ_G0023826
protein coding gene Chr17:73819319-73913285 (+)
LP/J MGP_LPJ_G0023943
protein coding gene Chr17:78902299-79006995 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023854
protein coding gene Chr17:84099587-84205221 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024482
protein coding gene Chr17:77298877-77398608 (+)
PWK/PhJ MGP_PWKPhJ_G0022983
protein coding gene Chr17:73698435-73794215 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022794
protein coding gene Chr17:74039566-74143413 (+)
WSB/EiJ MGP_WSBEiJ_G0023304
protein coding gene Chr17:78168783-78271113 (+)



Homology
more
  • Human Ortholog
    RASGRP3, RAS guanyl releasing protein 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RASGRP3, RAS guanyl releasing protein 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GRP3
  • Links
    NCBI Gene ID: 25780
    neXtProt AC: NX_Q8IV61
    UniProt: Q8IV61

  • Chr Location
    2p22.3; chr2:33436348-33564731 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutant mice are viable and fertile with no obvious abnormalities in the kidneys or vasculature.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000071042 Ensembl Gene Model | MGI Sequence Detail 93139 C57BL/6J ±  kb
    transcript ENSMUST00000164192 Ensembl | MGI Sequence Detail 4665 Not Applicable  
    polypeptide ENSMUSP00000129393 Ensembl | MGI Sequence Detail 691 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • InterPro Domains
      IPR020454 Diacylglycerol/phorbol-ester binding
      IPR018247 EF-Hand 1, calcium-binding site
      IPR002048 EF-hand domain
      IPR011992 EF-hand domain pair
      IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
      IPR036964 Ras guanine-nucleotide exchange factor catalytic domain superfamily
      IPR023578 Ras guanine nucleotide exchange factor domain superfamily
      IPR001895 Ras guanine-nucleotide exchange factors catalytic domain
      IPR029645 Ras guanyl-releasing protein 1/3
      IPR000651 Ras-like guanine nucleotide exchange factor, N-terminal
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 7
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2685173
    References
    more
    • Summaries
      All 30
      Developmental Gene Expression 4
      Gene Ontology 3
      Phenotypes 8
    • Earliest
      J:94466 Aiba Y, et al., Activation of RasGRP3 by phosphorylation of Thr-133 is required for B cell receptor-mediated Ras activation. Proc Natl Acad Sci U S A. 2004 Nov 23;101(47):16612-7
    • Latest
      J:195716 Golec DP, et al., RasGRP1, but not RasGRP3, is required for efficient thymic beta-selection and ERK activation downstream of CXCR4. PLoS One. 2013;8(1):e53300

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory