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Enpp7 Gene Detail
Summary
  • Symbol
    Enpp7
  • Name
    ectonucleotide pyrophosphatase/phosphodiesterase 7
  • Synonyms
    Alk-SMase, LOC238011
  • Feature Type
    protein coding gene
  • IDs
    MGI:3027917
    NCBI Gene: 238011
  • Gene Overview
    MyGene.info: ENPP7
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:118988188-118992841 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 83.33 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    6 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3027917
protein coding gene Chr11:118988108-118993270 (.)
129S1/SvImJ MGP_129S1SvImJ_G0019471
protein coding gene Chr11:123329283-123333920 (+)
A/J MGP_AJ_G0019439
protein coding gene Chr11:117882465-117887118 (+)
AKR/J MGP_AKRJ_G0019409
protein coding gene Chr11:121440572-121445209 (+)
BALB/cJ MGP_BALBcJ_G0019414
protein coding gene Chr11:118243131-118247776 (+)
C3H/HeJ MGP_C3HHeJ_G0019220
protein coding gene Chr11:121754202-121758847 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019863
protein coding gene Chr11:127097997-127102638 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017488
protein coding gene Chr11:114879866-114884443 (+)
CAST/EiJ MGP_CASTEiJ_G0018774
protein coding gene Chr11:123192563-123229922 (+)
CBA/J MGP_CBAJ_G0019191
protein coding gene Chr11:132030882-132035527 (+)
DBA/2J MGP_DBA2J_G0019303
protein coding gene Chr11:117260588-117265233 (+)
FVB/NJ MGP_FVBNJ_G0019295
protein coding gene Chr11:116917319-116921954 (+)
LP/J MGP_LPJ_G0019373
protein coding gene Chr11:123652449-123657094 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019328
protein coding gene Chr11:130999379-131004116 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019902
protein coding gene Chr11:122110643-122115286 (+)
PWK/PhJ MGP_PWKPhJ_G0018540
protein coding gene Chr11:118573499-118683659 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018332
protein coding gene Chr11:121853018-121880855 (+)
WSB/EiJ MGP_WSBEiJ_G0018826
protein coding gene Chr11:122072390-122077045 (+)



Homology
more
  • Human Ortholog
    ENPP7, ectonucleotide pyrophosphatase/phosphodiesterase 7
  • Vertebrate Orthologs
    13
  • Human Ortholog
    ENPP7, ectonucleotide pyrophosphatase/phosphodiesterase 7
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ALK-SMase, E-NPP 7, NPP7, NPP-7
  • Links
    NCBI Gene ID: 339221
    neXtProt AC: NX_Q6UWV6
    UniProt: Q6UWV6

  • Chr Location
    17q25.3; chr17:79730919-79742926 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit intestinal epithelium hypertrophy, decreased crypt and villi width, and impaired sphingomyelin digestion.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000046697 Ensembl Gene Model | MGI Sequence Detail 4654 C57BL/6J ±  kb
transcript ENSMUST00000092373 Ensembl | MGI Sequence Detail 1370 Not Applicable  
polypeptide ENSMUSP00000090027 Ensembl | MGI Sequence Detail 446 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    4 Sequences
  • InterPro Domains
    IPR017849 Alkaline phosphatase-like, alpha/beta/alpha
    IPR017850 Alkaline-phosphatase-like, core domain superfamily
    IPR029895 Ectonucleotide pyrophosphatase/phosphodiesterase family member 7
    IPR002591 Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase
Molecular
Reagents
less
  • All nucleic 3
    cDNA 3

    Microarray probesets 1
Other
Accession IDs
less
MGI:2685100
References
more
  • Summaries
    All 19
    Gene Ontology 2
    Phenotypes 4
  • Earliest
    J:85836 Duan RD, et al., Identification of human intestinal alkaline sphingomyelinase as a novel ecto-enzyme related to the nucleotide phosphodiesterase family. J Biol Chem. 2003 Oct 3;278(40):38528-36
  • Latest
    J:211198 Zhang P, et al., Alkaline sphingomyelinase (NPP7) promotes cholesterol absorption by affecting sphingomyelin levels in the gut: A study with NPP7 knockout mice. Am J Physiol Gastrointest Liver Physiol. 2014 May 15;306(10):G903-8

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory