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Kng2
Gene Detail
Symbol

Name
ID
Kng2
kininogen 2
MGI:3027157
Synonyms
Kininogen-II
Feature Type
protein coding gene
Genetic Map
Chromosome 16
13.82 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr16:22985854-23029101 bp, - strand
From VEGA annotation of GRCm38

  43248 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:88343  Vertebrate Homology Class
1 human; 2 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: KNG1
Gene Tree: Kng2

Human
homologs
KNG1, kininogen 1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 3827
neXtProt AC: NX_P01042

Human Synonyms: BDK, BK, KNG

Human Chr (Location): 3q27; chr3:186717309-186744410 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human KNG1

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(2) Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Interactions
Kng2 interacts with 147 markers (Mir1a-1, Mir1a-2, Mir19a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process negative regulation of endopeptidase activity
Component blood microparticle, cytosol, ...
Function cysteine-type endopeptidase inhibitor activity, receptor binding
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(51)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(52) Genomic(1) cDNA(51)
Microarray probesets(1)
Other database
links
VEGA Gene Model OTTMUSG00000028303 (Evidence)
Ensembl Gene Model ENSMUSG00000060459 (Evidence)
Entrez Gene 385643 (Evidence)
UniGene 440414
DoTS DT.110718576, DT.102554113, DT.94284252, DT.99855341, DT.101339889
NIA Mouse Gene Index U235382
Consensus CDS Project CCDS28072.1, CCDS49801.1, CCDS49802.1
International Mouse Phenotyping Consortium Status Kng2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028303 VEGA Gene Model | MGI Sequence Detail 43248 C57BL/6J ±  kb
transcript OTTMUST00000070137 VEGA | MGI Sequence Detail 2294 Not Applicable 
polypeptide OTTMUSP00000035712 VEGA | MGI Sequence Detail 644 Not Applicable 

For the selected sequences
All sequences(49) RefSeq(8) UniProt(5)
Polymorphisms
SNPs within 2kb(246 from dbSNP Build 137)    SNPs within 2kb including multiple locations(308)
Protein-related
information
ResourceIDDescription
InterPro IPR002395 HMW kininogen
InterPro IPR027358 Kininogen-type cystatin domain
InterPro IPR000010 Proteinase inhibitor I25, cystatin
InterPro IPR018073 Proteinase inhibitor I25, cystatin, conserved site
References
(Earliest) J:90550 Cardoso CC, et al., Structure and expression of two kininogen genes in mice. Biol Chem. 2004 Mar-Apr;385(3-4):295-301
(Latest) J:201630 Ryder E, et al., Molecular characterization of mutant mouse strains generated from the EUCOMM/KOMP-CSD ES cell resource. Mamm Genome. 2013 Aug;24(7-8):286-94
All references(27)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory