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Kng2 Gene Detail
Summary
  • Symbol
    Kng2
  • Name
    kininogen 2
  • Synonyms
    Kininogen-II
  • Feature Type
    protein coding gene
  • IDs
    MGI:3027157
    NCBI Gene: 385643
  • Gene Overview
    MyGene.info: KNG1
Location & Maps
more
  • Sequence Map
    Chr16:22985854-23029101 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      43248 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 13.82 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    KNG1, kininogen 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    KNG1, kininogen 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BDK, BK, KNG
  • Links
    NCBI Gene ID: 3827
    neXtProt AC: NX_P01042

  • Chr Location
    3q27; chr3:186717309-186744410 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 88343
    1 human;2 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog
  • HCOP
    human homology predictions: KNG1
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human KNG1 associations

Human Disease Mouse Models
       High Molecular Weight Kininogen Deficiency   OMIM: 228960
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028303 VEGA Gene Model | MGI Sequence Detail 43248 C57BL/6J ±  kb
transcript OTTMUST00000070137 VEGA | MGI Sequence Detail 2294 Not Applicable  
polypeptide OTTMUSP00000035712 VEGA | MGI Sequence Detail 644 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    226 from dbSNP Build 142
Protein
Information
less
  • UniProt
    5 Sequences
  • InterPro Domains
    IPR000010 Cystatin domain
    IPR002395 HMW kininogen
    IPR027358 Kininogen-type cystatin domain
    IPR018073 Proteinase inhibitor I25, cystatin, conserved site
Molecular
Reagents
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  • All nucleic 52
    Genomic 1
    cDNA 51

    Microarray probesets 1
References
more
  • Summaries
    All 25
    Developmental Gene Expression 1
    Gene Ontology 2
    Phenotypes 6
  • Earliest
    J:90550 Cardoso CC, et al., Structure and expression of two kininogen genes in mice. Biol Chem. 2004 Mar-Apr;385(3-4):295-301
  • Latest
    J:201630 Ryder E, et al., Molecular characterization of mutant mouse strains generated from the EUCOMM/KOMP-CSD ES cell resource. Mamm Genome. 2013 Aug;24(7-8):286-94

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory