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Kng2 Gene Detail
Summary
  • Symbol
    Kng2
  • Name
    kininogen 2
  • Synonyms
    Kininogen-II
  • Feature Type
    protein coding gene
  • IDs
    MGI:3027157
    NCBI Gene: 385643
  • Gene Overview
    MyGene.info: KNG1
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:22985852-23029101 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 13.82 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    226 from dbSNP Build 142
  • Strain Annotations
    10
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3027157
protein coding gene Chr16:22985852-23029101 (-)
129S1/SvImJ no annotation
A/J MGP_AJ_G0022638
protein coding gene Chr16:19540841-19567377 (-)
AKR/J no annotation
BALB/cJ MGP_BALBcJ_G0022643
protein coding gene Chr16:19726135-19777314 (-)
C3H/HeJ MGP_C3HHeJ_G0022407
protein coding gene Chr16:20445067-20522066 (-)
C57BL/6NJ no annotation
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0021937
protein coding gene Chr16:20437115-20496775 (-)
CBA/J no annotation
DBA/2J no annotation
FVB/NJ MGP_FVBNJ_G0022487
protein coding gene Chr16:19476344-19537381 (-)
LP/J MGP_LPJ_G0022579
protein coding gene Chr16:20282982-20359679 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022506
protein coding gene Chr16:21386601-21451237 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023104
protein coding gene Chr16:20278744-20347284 (-)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0021980
protein coding gene Chr16:20254441-20310685 (-)



Homology
more
  • Human Ortholog
    KNG1, kininogen 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    KNG1, kininogen 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BDK, BK, HMWK, KNG
  • Links
    NCBI Gene ID: 3827
    neXtProt AC: NX_P01042
    UniProt: P01042

  • Chr Location
    3q27.3; chr3:186717309-186744410 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 88343
    1 human;2 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: KNG1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 385643 NCBI Gene Model | MGI Sequence Detail 43250 C57BL/6J ±  kb
transcript NM_201375 RefSeq | MGI Sequence Detail 2305 C57BL/6  
polypeptide NP_958763 RefSeq | MGI Sequence Detail 644 C57BL/6  
For the selected sequence
Protein
Information
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  • UniProt
    8 Sequences
  • InterPro Domains
    IPR000010 Cystatin domain
    IPR002395 HMW kininogen
    IPR027358 Kininogen-type cystatin domain
    IPR018073 Proteinase inhibitor I25, cystatin, conserved site
Molecular
Reagents
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  • All nucleic 53
    Genomic 2
    cDNA 51

    Microarray probesets 1
References
more
  • Summaries
    All 29
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 8
  • Earliest
    J:90550 Cardoso CC, et al., Structure and expression of two kininogen genes in mice. Biol Chem. 2004 Mar-Apr;385(3-4):295-301
  • Latest
    J:265607 Naba A, et al., Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression. Sci Rep. 2017 Jan 10;7:40495

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory