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Tgm4
Gene Detail
Symbol

Name
ID
Tgm4
transglutaminase 4 (prostate)
MGI:3027002
Synonyms
9530008N10Rik, Eapa1, experimental autoimmune prostatitis antigen 1
Feature Type
protein coding gene
Genetic Map
Chromosome 9
73.56 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:123034739-123067561 bp, + strand
From VEGA annotation of GRCm38

  32823 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20689  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 chicken; 2 western clawed frog

HCOP human homology predictions: TGM4
Protein SuperFamily: TGM_EBP42
Gene Tree: Tgm4

Human
homologs
TGM4, transglutaminase 4
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 7047
neXtProt AC: NX_P49221

Human Synonyms: hTGP, TGP

Human Chr (Location): 3p22-p21.33; chr3:44874592-44914601 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit impaired copulatory plug formation, reduced fertilization and few litters sired.
 
Interactions
Tgm4 interacts with 102 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process mating plug formation, peptide cross-linking
Component cytoplasm, extracellular exosome, ...
Function metal ion binding, protein-glutamine gamma-glutamyltransferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (103)    Tissues (97)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
RT-PCR 9
cDNA source data(5)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(6) cDNA(5) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000023752 (Evidence)
Ensembl Gene Model ENSMUSG00000025787 (Evidence)
Entrez Gene 331046 (Evidence)
DFCI TC1653311, TC1634605, TC1574477
NIA Mouse Gene Index U011191
EC 2.3.2.13
Consensus CDS Project CCDS23653.1
International Mouse Phenotyping Consortium Status Tgm4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023752 VEGA Gene Model | MGI Sequence Detail 32823 C57BL/6J ±  kb
transcript OTTMUST00000058027 VEGA | MGI Sequence Detail 2770 Not Applicable 
polypeptide OTTMUSP00000028062 VEGA | MGI Sequence Detail 670 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(8) UniProt(1)
Polymorphisms
SNPs within 2kb(129 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR014756 Immunoglobulin E-set
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR023608 Protein-glutamine gamma-glutamyltransferase, eukaryota
InterPro IPR013808 Transglutaminase, conserved site
InterPro IPR008958 Transglutaminase, C-terminal
InterPro IPR002931 Transglutaminase-like
InterPro IPR001102 Transglutaminase, N-terminal
Protein Ontology PR:000016295 protein-glutamine gamma-glutamyltransferase 4
References
(Earliest) J:122989 Visel A, et al., GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
(Latest) J:195173 Dean MD, Genetic disruption of the copulatory plug in mice leads to severely reduced fertility. PLoS Genet. 2013 Jan;9(1):e1003185
All references(29)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory