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Tgm4
Gene Detail
 Symbol
Name
ID
Tgm4
transglutaminase 4 (prostate)
MGI:3027002
Synonyms 9530008N10Rik, Eapa1, experimental autoimmune prostatitis antigen 1
Feature Type protein coding gene
Genetic Map
Chromosome 9
73.56 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:123034739-123067561 bp, + strand
From VEGA annotation of GRCm38

  32823 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20689  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 chicken; 2 western clawed frog

Protein SuperFamily: TGM_EBP42
Gene Tree: Tgm4

Human
homologs
Human Homolog TGM4, transglutaminase 4
NCBI Gene ID 7047
neXtProt AC  NX_P49221
Human Synonyms  hTGP, TGP
Human Chr (Location)  3p22-p21.33; chr3:44874606-44914601 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit impaired copulatory plug formation, reduced fertilization and few litters sired.
 
Interactions
Tgm4 interacts with 102 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process mating plug formation, peptide cross-linking
Component cytoplasm, extracellular matrix, ...
Function metal ion binding, protein-glutamine gamma-glutamyltransferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (103)    Tissues (97)    Images (2)
Theiler Stages: 22, 28
Assay TypeResults
RNA in situ 94
RT-PCR 9
cDNA source data(5)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(6) cDNA(5) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000023752 (Evidence)
Ensembl Gene ModelENSMUSG00000025787 (Evidence)
Entrez Gene331046 (Evidence)
DFCITC1574477, TC1634605, TC1653311
NIA Mouse Gene IndexU011191
EC2.3.2.13
Consensus CDS ProjectCCDS23653.1
International Mouse Knockout Project StatusTgm4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023752 VEGA Gene Model | MGI Sequence Detail 32823 C57BL/6J ±  kb
transcript OTTMUST00000058027 VEGA | MGI Sequence Detail 2770 Not Applicable 
polypeptide OTTMUSP00000028062 VEGA | MGI Sequence Detail 670 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(8) UniProt(1)
Polymorphisms SNPs within 2kb(129 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR014756 Immunoglobulin E-set
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR023608 Protein-glutamine gamma-glutamyltransferase, eukaryota
InterPro IPR013808 Transglutaminase, conserved site
InterPro IPR008958 Transglutaminase, C-terminal
InterPro IPR002931 Transglutaminase-like
InterPro IPR001102 Transglutaminase, N-terminal
Protein Ontology PR:000016295 protein-glutamine gamma-glutamyltransferase 4
References (Earliest) J:122989 Visel A, et al., GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
(Latest) J:195173 Dean MD, Genetic disruption of the copulatory plug in mice leads to severely reduced fertility. PLoS Genet. 2013 Jan;9(1):e1003185
All references(30)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory