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Zc3h12c Gene Detail
Summary
  • Symbol
    Zc3h12c
  • Name
    zinc finger CCCH type containing 12C
  • Synonyms
    C230027N18Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:3026959
    NCBI Gene: 244871
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:52111344-52168572 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 28.62 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    267 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3026959
protein coding gene Chr9:52109569-52168730 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034805
protein coding gene Chr9:51088324-51145580 (-)
A/J MGP_AJ_G0034786
protein coding gene Chr9:49497070-49555651 (-)
AKR/J MGP_AKRJ_G0034714
protein coding gene Chr9:50543687-50600915 (-)
BALB/cJ MGP_BALBcJ_G0034778
protein coding gene Chr9:49253551-49309804 (-)
C3H/HeJ MGP_C3HHeJ_G0034488
protein coding gene Chr9:51044782-51101074 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035297
protein coding gene Chr9:52501427-52557471 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032210
protein coding gene Chr9:48936775-48994406 (-)
CAST/EiJ MGP_CASTEiJ_G0033810
protein coding gene Chr9:51004243-51063960 (-)
CBA/J MGP_CBAJ_G0034459
protein coding gene Chr9:54319787-54382276 (-)
DBA/2J MGP_DBA2J_G0034618
protein coding gene Chr9:49354056-49410716 (-)
FVB/NJ MGP_FVBNJ_G0034560
protein coding gene Chr9:48568781-48625894 (-)
LP/J MGP_LPJ_G0034700
protein coding gene Chr9:51416269-51474482 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034603
protein coding gene Chr9:55914286-55981230 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035319
protein coding gene Chr9:50540681-50603599 (-)
PWK/PhJ MGP_PWKPhJ_G0033514
protein coding gene Chr9:49345174-49402806 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033350
protein coding gene Chr9:50821452-50881377 (-)
WSB/EiJ MGP_WSBEiJ_G0033922
protein coding gene Chr9:50541490-50598684 (-)



Homology
more
  • Human Ortholog
    ZC3H12C, zinc finger CCCH-type containing 12C
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ZC3H12C, zinc finger CCCH-type containing 12C
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MCPIP3
  • Links
    NCBI Gene ID: 85463
    neXtProt AC: NX_Q9C0D7
    UniProt: Q9C0D7

  • Chr Location
    11q22.3; chr11:110092425-110171841 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    31 phenotypes from 3 alleles in 4 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit lymphadenopathy associated with increased IFNgamma signaling.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000035164 Ensembl Gene Model | MGI Sequence Detail 57229 C57BL/6J ±  kb
    transcript ENSMUST00000165519 Ensembl | MGI Sequence Detail 6133 Not Applicable  
    polypeptide ENSMUSP00000127603 Ensembl | MGI Sequence Detail 903 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 9

      Microarray probesets 5
    References
    more
    • Summaries
      All 27
      Gene Ontology 3
      Phenotypes 7
    • Earliest
      J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
    • Latest
      J:277714 von Gamm M, et al., Immune homeostasis and regulation of the interferon pathway require myeloid-derived Regnase-3. J Exp Med. 2019 Jul 1;216(7):1700-1723

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    11/10/2020
    MGI 6.16
    The Jackson Laboratory