Zc3h12c MGI Mouse Gene Detail - MGI:3026959 - zinc finger CCCH type containing 12C

Symbol

Zc3h12c
Name

zinc finger CCCH type containing 12C
Synonyms

C230027N18Rik, Reg3, Regnase-3

Feature Type

protein coding gene
IDs

MGI:3026959
NCBI Gene: 244871
Alliance

genome feature page
Transcription Start Sites

18 TSS

Sequence Map

Chr9:52022644-52079872 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 28.62 cM
Mapping Data

2 experiments

SNPs within 2kb

1131 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3026959	protein coding gene	Chr9:52020869-52080028 (-)
129S1/SvImJ	ENSMUSG00200018011	protein coding gene	Chr9:49183173-49240411 (-)
A/J	ENSMUSG00195021775	protein coding gene	Chr9:48868865-48926094 (-)
AKR/J	ENSMUSG00220033479	protein coding gene	Chr9:48966807-49024033 (-)
BALB/cJ	ENSMUSG00180030404	protein coding gene	Chr9:48980202-49037435 (-)
C3H/HeJ	ENSMUSG00175012828	protein coding gene	Chr9:48992174-49049403 (-)
C57BL/6NJ	ENSMUSG00215035492	protein coding gene	Chr9:48951032-49008273 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032210	protein coding gene	Chr9:48936775-48994406 (-)
CAST/EiJ	ENSTCUG00005015531	protein coding gene	Chr9:48920360-48977736 (-)
CBA/J	ENSMUSG00210016492	protein coding gene	Chr9:49068981-49126207 (-)
DBA/2J	ENSMUSG00185010567	protein coding gene	Chr9:49106610-49163839 (-)
FVB/NJ	ENSMUSG00205032625	protein coding gene	Chr9:49349008-49406197 (-)
JF1/MsJ	ENSUMUG00000038155	protein coding gene	Chr9:49157720-49214598 (-)
LP/J	ENSMUSG00230035687	protein coding gene	Chr9:49394575-49451802 (-)
NOD/ShiLtJ	ENSMUSG00190023629	protein coding gene	Chr9:49186653-49243888 (-)
NZO/HlLtJ	ENSMUSG00225041969	protein coding gene	Chr9:49362857-49420032 (-)
PWK/PhJ	ENSLUMG00010020808	protein coding gene	Chr9:49124337-49181626 (-)
SPRET/EiJ	ENSMSPG00010010784	protein coding gene	Chr9:49991955-50049231 (-)
WSB/EiJ	ENSIUOG00005017474	protein coding gene	Chr9:48593701-48650945 (-)

Human Ortholog

ZC3H12C, zinc finger CCCH-type containing 12C

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ZC3H12C, zinc finger CCCH-type containing 12C
Synonyms

MCPIP3
Links

HGNC:29362

NCBI Gene ID: 85463

UniProt: Q9C0D7
Chr Location

11q22.3; chr11:110093392-110171841 (+) GRCh38

MGI Vertebrate Homology

Zc3h12c stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: ZC3H12C
Gene Tree

Zc3h12c

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Phenotype Summary

26 phenotypes from 3 alleles in 4 genetic backgrounds
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Endonuclease-mediated

6
Gene trapped

6
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

35 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit lymphadenopathy associated with increased IFNgamma signaling.

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All GO Annotations

8
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

597
cDNA Data

9

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase zc3h12c

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All Sequences

43
RefSeq

6
UniProt

2
CCDS

CCDS52794.1

Ensembl

ENSMUSG00000035164 (Evidence)
NCBI Gene

244871

			Length	Strain/Species	Flank
genomic	ENSMUSG00000035164	Ensembl Gene Model \| MGI Sequence Detail	57229	C57BL/6J	± kb
transcript	ENSMUST00000165519	Ensembl \| MGI Sequence Detail	6133	Not Applicable
polypeptide	ENSMUSP00000127603	Ensembl \| MGI Sequence Detail	903	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000030435 probable ribonuclease ZC3H12C

(term hierarchy)
PDB

7NDH, 7NDI, 7NDJ, 7NDK
EC

3.1.-.-
InterPro Domains

IPR040757 Endoribonuclease Regnase 1/ZC3H12, C-terminal domain

IPR040546 Rege-1, UBA-like domain

IPR021869 Ribonuclease Zc3h12a-like, NYN domain

IPR051101 ZC3H12/N4BP1 Ribonuclease and Regulator

IPR000571 Zinc finger, CCCH-type

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All nucleic 9

cDNA 9

Microarray probesets 5

Summaries

All 40

Gene Ontology 3

Phenotypes 14
Earliest

J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
Latest

J:385318 Forster PM, et al., Blimp-1 integrates alarmin signals in ILC2s and drives proinflammatory functions required for type 2 immunity. J Exp Med. 2026 May 4;223(5)

TSS for Zc3h12c:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr89584	Chr9:52080188-52080203 (-)	-324 bp
Tssr89583	Chr9:52080138-52080171 (-)	-283 bp
Tssr89582	Chr9:52080092-52080106 (-)	-227 bp
Tssr89581	Chr9:52080040-52080068 (-)	-182 bp
Tssr89580	Chr9:52079975-52079980 (-)	-106 bp
Tssr89579	Chr9:52078679-52078682 (-)	1,191 bp
Tssr89578	Chr9:52076038-52076069 (-)	3,818 bp
Tssr2873	Chr9:52075912-52075924 (-)	3,954 bp
Tssr89577	Chr9:52075865-52075876 (-)	4,001 bp
Tssr89576	Chr9:52075816-52075824 (-)	4,052 bp
Tssr89575	Chr9:52060651-52060672 (-)	19,210 bp
Tssr89574	Chr9:52055220-52055232 (-)	24,646 bp
Tssr89573	Chr9:52053052-52053064 (-)	26,814 bp
Tssr89572	Chr9:52053030-52053047 (-)	26,833 bp
Tssr89571	Chr9:52052929-52052947 (-)	26,934 bp
Tssr89570	Chr9:52039164-52039177 (-)	40,701 bp
Tssr89569	Chr9:52036771-52036783 (-)	43,095 bp
Tssr89568	Chr9:52024282-52024319 (-)	55,571 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24