Cdin1 Gene Detail

Summary

• Symbol
  Cdin1
• Name
  CDAN1 interacting nuclease 1
• Synonyms
  BC052040, MGC:62402

• Feature Type
  protein coding gene
• IDs
  MGI:3026886
  NCBI Gene: 399568
• Alliance
  gene page
• Transcription Start Sites
  5 TSS

Location &
Maps

• Sequence Map
  Chr2:115412197-115609249 bp, + strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 2, 58.18 cM
• Mapping Data
  2 experiments

Strain
Comparison

• SNPs within 2kb
  908 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3026886	protein coding gene	Chr2:115411388-115609263 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026305	protein coding gene	Chr2:118135798-118337667 (+)
A/J	MGP_AJ_G0026266	protein coding gene	Chr2:113350671-113551438 (+)
AKR/J	MGP_AKRJ_G0026245	protein coding gene	Chr2:116493612-116700393 (+)
BALB/cJ	MGP_BALBcJ_G0026279	protein coding gene	Chr2:113588098-113787321 (+)
C3H/HeJ	MGP_C3HHeJ_G0026024	protein coding gene	Chr2:116929054-117131884 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026726	protein coding gene	Chr2:122042124-122248180 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024106	protein coding gene	Chr2:108465267-108666849 (+)
CAST/EiJ	MGP_CASTEiJ_G0025487	protein coding gene	Chr2:117228235-117437922 (+)
CBA/J	MGP_CBAJ_G0026001	protein coding gene	Chr2:126339272-126552271 (+)
DBA/2J	MGP_DBA2J_G0026140	protein coding gene	Chr2:112778989-112977946 (+)
FVB/NJ	MGP_FVBNJ_G0026102	protein coding gene	Chr2:111621921-111820232 (+)
LP/J	MGP_LPJ_G0026241	protein coding gene	Chr2:118442293-118648130 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026121	protein coding gene	Chr2:130772181-130980357 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026781	protein coding gene	Chr2:116604377-116807671 (+)
PWK/PhJ	MGP_PWKPhJ_G0025223	protein coding gene	Chr2:112327453-112526987 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025022	protein coding gene	Chr2:115741423-115942641 (+)
WSB/EiJ	MGP_WSBEiJ_G0025556	protein coding gene	Chr2:117420574-117621151 (+)

Homology

• Human Ortholog
  CDIN1, CDAN1 interacting nuclease 1

• Vertebrate Orthologs
  3

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  CDIN1, CDAN1 interacting nuclease 1
  
• Synonyms
  C15orf41, HH114
• Links
  HGNC:26929

  NCBI Gene ID: 84529

  neXtProt AC: NX_Q9Y2V0

  UniProt: Q9Y2V0

  
  
• Chr Location
  15q14; chr15:36579626-36810248 (+)  GRCh38

---

• MGI Vertebrate Homology
  Cdin1 stringent orthology
  1 human;1 mouse;1 rat;1 zebrafish
  
• HCOP
  vertebrate homology predictions: CDIN1
• Gene Tree
  Cdin1
  

Human Diseases

• Diseases
  1 with human CDIN1 associations

				Human Disease	Mouse Models
				congenital dyserythropoietic anemia type Ib IDs congenital dyserythropoietic anemia type Ib       DOID:0111397 MESH:D000742 OMIM:615631 UMLS_CUI:C0271933

Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  5 phenotypes from 1 allele in 1 genetic background
  15 phenotype references
  

• All Mutations and Alleles
  22
• Chemically induced (other)
  1
• Endonuclease-mediated
  3
• Gene trapped
  15
• Radiation induced
  1
• Targeted
  2
• Genomic Mutations
  2 involving Cdin1
• Incidental Mutations
  Mutagenetix , APF
• Find Mice (IMSR)
  30 strains or lines available
• Comparison Matrix
  Gene Expression + Phenotype

Mice homozygous for a knock-out allele show normal blastocyst formation but exhibit complete embryonic lethality between implantation and somite formation.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  9
• GO References
  3

Expression

• Assay Results
  801
• Tissues
  24
• cDNA Data
  12
• Literature Summary
  2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  ZFIN cdin1

Sequences &
Gene Models

• All Sequences
  67
• RefSeq
  32
• UniProt
  2
• CCDS
  CCDS50662.1, CCDS50663.1

• Ensembl
  ENSMUSG00000040282 (Evidence)
• NCBI Gene
  399568

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000040282	Ensembl Gene Model | MGI Sequence Detail	197053	C57BL/6J
transcript	ENSMUST00000166472	Ensembl | MGI Sequence Detail	2770	Not Applicable
polypeptide	ENSMUSP00000126772	Ensembl | MGI Sequence Detail	287	Not Applicable

Protein
Information

• UniProt
  2 Sequences
• Protein Ontology
  PR:000060139 CDAN1-interacting nuclease 1
  (term hierarchy)
• InterPro Domains
  IPR029404 CDAN1-interacting nuclease 1

Molecular
Reagents

• All nucleic 13

  cDNA 12

  Primer pair 1

  
  

  Microarray probesets 3

References

• Summaries
  All 38

  Developmental Gene Expression 2

  Gene Ontology 3

  Phenotypes 15
• Earliest
  J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
• Latest
  J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582

TSS for Cdin1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr19462	Chr2:115412132-115412146 (+)	-58 bp
Tssr19463	Chr2:115412148-115412224 (+)	-11 bp
Tssr19464	Chr2:115412246-115412273 (+)	63 bp
Tssr19465	Chr2:115412276-115412303 (+)	93 bp
Tssr19466	Chr2:115429666-115429681 (+)	17,477 bp