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Ccdc87 Gene Detail
Summary
  • Symbol
    Ccdc87
  • Name
    coiled-coil domain containing 87
  • Synonyms
    4931419P11Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:3026882
    NCBI Gene: 399599
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:4839366-4842528 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 4.11 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    36 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3026882
protein coding gene Chr19:4839366-4842528 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024676
protein coding gene Chr19:1735969-1739131 (+)
A/J MGP_AJ_G0024642
protein coding gene Chr19:1655697-1658859 (+)
AKR/J MGP_AKRJ_G0024615
protein coding gene Chr19:1702972-1706134 (+)
BALB/cJ MGP_BALBcJ_G0024642
protein coding gene Chr19:1651656-1654818 (+)
C3H/HeJ MGP_C3HHeJ_G0024410
protein coding gene Chr19:1704851-1708013 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025089
protein coding gene Chr19:1789649-1792811 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022519
protein coding gene Chr19:1588091-1591262 (+)
CAST/EiJ MGP_CASTEiJ_G0023882
protein coding gene Chr19:1725430-1728592 (+)
CBA/J MGP_CBAJ_G0024381
protein coding gene Chr19:1865413-1868575 (+)
DBA/2J MGP_DBA2J_G0024509
protein coding gene Chr19:1623235-1626397 (+)
FVB/NJ MGP_FVBNJ_G0024476
protein coding gene Chr19:1645332-1648494 (+)
LP/J MGP_LPJ_G0024595
protein coding gene Chr19:1747788-1750950 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024506
protein coding gene Chr19:1771955-1775117 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025137
protein coding gene Chr19:1695005-1698167 (+)
PWK/PhJ MGP_PWKPhJ_G0023628
protein coding gene Chr19:1672804-1675966 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023433
protein coding gene Chr19:1683609-1686770 (+)
WSB/EiJ MGP_WSBEiJ_G0023944
protein coding gene Chr19:1695055-1698211 (+)



Homology
more
  • Human Ortholog
    CCDC87, coiled-coil domain containing 87
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CCDC87, coiled-coil domain containing 87
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 55231
    neXtProt AC: NX_Q9NVE4
    UniProt: Q9NVE4

  • Chr Location
    11q13.2; chr11:66590169-66593083 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit male subfertility or infertility associated with severe sperm head defects, decreased initial sperm motility, impaired acrosome reaction, and loss of fertilizing capacity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 399599 NCBI Gene Model | MGI Sequence Detail 3163 C57BL/6J ±  kb
    transcript NM_207268 RefSeq | MGI Sequence Detail 3163 C57BL/6  
    polypeptide Q8CDL9 UniProt | EBI | MGI Sequence Detail 855 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 8

      Microarray probesets 2
    References
    more
    • Summaries
      All 22
      Gene Ontology 2
      Phenotypes 3
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:265624 Wang T, et al., Ccdc87 is critical for sperm function and male fertility. Biol Reprod. 2018 May 3;

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    02/23/2021
    MGI 6.16
    The Jackson Laboratory