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Ptprh Gene Detail
Summary
  • Symbol
    Ptprh
  • Name
    protein tyrosine phosphatase, receptor type, H
  • Synonyms
    SAP-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:3026877
    NCBI Gene: 545902
  • Gene Overview
    MyGene.info: PTPRH
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:4548614-4604041 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 2.63 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    181 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3026877
protein coding gene Chr7:4548612-4604041 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031551
protein coding gene Chr7:1469499-1519376 (-)
A/J MGP_AJ_G0031525
protein coding gene Chr7:1468477-1534626 (-)
AKR/J MGP_AKRJ_G0031454
protein coding gene Chr7:1546479-1598979 (-)
BALB/cJ MGP_BALBcJ_G0031533
protein coding gene Chr7:1534160-1579270 (-)
C3H/HeJ MGP_C3HHeJ_G0031254
protein coding gene Chr7:1511867-1572256 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031994
protein coding gene Chr7:1507275-1519128 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029118
protein coding gene Chr7:1241297-1252103 (-)
CAST/EiJ MGP_CASTEiJ_G0030618
protein coding gene Chr7:1451732-1510749 (-)
CBA/J MGP_CBAJ_G0031212
protein coding gene Chr7:1708125-1768325 (-)
DBA/2J MGP_DBA2J_G0031371
protein coding gene Chr7:1435433-1445326 (-)
FVB/NJ MGP_FVBNJ_G0031323
protein coding gene Chr7:1415202-1481027 (-)
LP/J MGP_LPJ_G0031456
protein coding gene Chr7:1559897-1635632 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031362
protein coding gene Chr7:1635479-1702944 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032024
protein coding gene Chr7:1449641-1504399 (-)
PWK/PhJ MGP_PWKPhJ_G0030346
protein coding gene Chr7:1622338-1632290 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030171
protein coding gene Chr7:1511875-1561637 (-)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    PTPRH, protein tyrosine phosphatase, receptor type H
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PTPRH, protein tyrosine phosphatase, receptor type H
    Orthology source: HomoloGene, HGNC
  • Synonyms
    R-PTP-H, SAP1
  • Links
    NCBI Gene ID: 5794
    neXtProt AC: NX_Q9HD43
    UniProt: Q9HD43

  • Chr Location
    19q13.42; chr19:55181247-55209506 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    3 phenotype references
Mice homozygous for a null alllele exhibit normal intestinal epithelial cell morphology and physiology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 545902 NCBI Gene Model | MGI Sequence Detail 55428 C57BL/6J ±  kb
transcript NM_207270 RefSeq | MGI Sequence Detail 4020 C57BL/6  
polypeptide E9Q0N2 UniProt | EBI | MGI Sequence Detail 971 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 4
    cDNA 4

    Microarray probesets 1
References
more
  • Summaries
    All 22
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 3
  • Earliest
    J:146871 Sadakata H, et al., SAP-1 is a microvillus-specific protein tyrosine phosphatase that modulates intestinal tumorigenesis. Genes Cells. 2009 Mar;14(3):295-308
  • Latest
    J:226057 Murata Y, et al., Protein tyrosine phosphatase SAP-1 protects against colitis through regulation of CEACAM20 in the intestinal epithelium. Proc Natl Acad Sci U S A. 2015 Aug 4;112(31):E4264-71

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory