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Ptprh Gene Detail
Summary
  • Symbol
    Ptprh
  • Name
    protein tyrosine phosphatase, receptor type, H
  • Synonyms
    SAP-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:3026877
    NCBI Gene: 545902
  • Gene Overview
    MyGene.info: PTPRH
Location & Maps
more
  • Genetic Map
    Chromosome 7, 2.63 cM
  • Mapping Data
    2 experiments
Homology
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  • Human Ortholog
    PTPRH, protein tyrosine phosphatase, receptor type H
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PTPRH, protein tyrosine phosphatase, receptor type H
    Orthology source: HGNC, HomoloGene
  • Synonyms
    R-PTP-H, SAP1
  • Links
    NCBI Gene ID: 5794

  • Chr Location
    19q13.4; chr19:55181247-55209506 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    3 phenotype references
Mice homozygous for a null alllele exhibit normal intestinal epithelial cell morphology and physiology.
Gene Ontology
(GO)
Classifications
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Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000058448 VEGA Gene Model | MGI Sequence Detail 55430 C57BL/6J ±  kb
transcript OTTMUST00000143546 VEGA | MGI Sequence Detail 3495 Not Applicable  
polypeptide OTTMUSP00000074826 VEGA | MGI Sequence Detail 971 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    181 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • InterPro Domains
    IPR003961 Fibronectin type III
    IPR013783 Immunoglobulin-like fold
    IPR016130 Protein-tyrosine phosphatase, active site
    IPR003595 Protein-tyrosine phosphatase, catalytic
    IPR029021 Protein-tyrosine phosphatase-like
    IPR000242 PTP type protein phosphatase
    IPR028855 Receptor-type tyrosine-protein phosphatase H
    IPR000387 Tyrosine specific protein phosphatases domain
Molecular
Reagents
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  • All nucleic 3
    cDNA 3

    Microarray probesets 1
References
more
  • Summaries
    All 17
    Developmental Gene Expression 1
    Phenotypes 3
  • Earliest
    J:146871 Sadakata H, et al., SAP-1 is a microvillus-specific protein tyrosine phosphatase that modulates intestinal tumorigenesis. Genes Cells. 2009 Mar;14(3):295-308
  • Latest
    J:226057 Murata Y, et al., Protein tyrosine phosphatase SAP-1 protects against colitis through regulation of CEACAM20 in the intestinal epithelium. Proc Natl Acad Sci U S A. 2015 Aug 4;112(31):E4264-71

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory