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Zfyve1
Gene Detail
Symbol

Name
ID
Zfyve1
zinc finger, FYVE domain containing 1
MGI:3026685
Synonyms
mKIAA1589
Feature Type
protein coding gene
Genetic Map
Chromosome 12
38.76 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr12:83546941-83597147 bp, - strand
From Ensembl annotation of GRCm38

  50207 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10945  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Zfyve1

Human
homologs
Human Homolog ZFYVE1, zinc finger, FYVE domain containing 1
NCBI Gene ID 53349
neXtProt AC  NX_Q9HBF4
Human Synonyms  DFCP1, PPP1R172, SR3, TAFF1, ZNFN2A1
Human Chr (Location)  14q24.2; chr14:72969445-73027212 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(248) : Gene trapped(248)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Zfyve1 interacts with 176 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process negative regulation of phosphatase activity
Component autophagic vacuole, endoplasmic reticulum, ...
Function 1-phosphatidylinositol binding, metal ion binding, ...
External Resources: FuncBase
Expression
cDNA source data(81)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(81) cDNA(81)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000042628 (Evidence)
Entrez Gene217695 (Evidence)
UniGene59257
DFCITC1579705, TC1604026, TC1605492
DoTSDT.60103197, DT.99596890, DT.110912945, DT.102547837, DT.97409166
NIA Mouse Gene IndexU034152
Consensus CDS ProjectCCDS26028.1
International Mouse Knockout Project StatusZfyve1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000042628 Ensembl Gene Model | MGI Sequence Detail 50207 C57BL/6J ±  kb
transcript ENSMUST00000048319 Ensembl | MGI Sequence Detail 3869 Not Applicable 
polypeptide ENSMUSP00000042224 Ensembl | MGI Sequence Detail 777 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(10) UniProt(3)
Polymorphisms
SNPs within 2kb(381 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR011011 Zinc finger, FYVE/PHD-type
InterPro IPR017455 Zinc finger, FYVE-related
InterPro IPR000306 Zinc finger, FYVE-type
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
Protein Ontology PR:000032428 zinc finger FYVE domain-containing protein 1
References
(Earliest) J:85162 Hansen J, et al., A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9918-22
(Latest) J:195131 Hamasaki M, et al., Autophagosomes form at ER-mitochondria contact sites. Nature. 2013 Mar 21;495(7441):389-93
All references(31)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory