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Scn4b Gene Detail
Summary
  • Symbol
    Scn4b
  • Name
    sodium channel, type IV, beta
  • Synonyms
    LOC384934
  • Feature Type
    protein coding gene
  • IDs
    MGI:2687406
    NCBI Gene: 399548
  • Gene Overview
    MyGene.info: SCN4B
Location & Maps
more
  • Sequence Map
    Chr9:45138437-45154152 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      15716 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    SCN4B, sodium voltage-gated channel beta subunit 4
  • Vertebrate Orthologs
    11
  • Human Ortholog
    SCN4B, sodium voltage-gated channel beta subunit 4
    Orthology source: HomoloGene
  • Synonyms
    ATFB17, LQT10, Navbeta4
  • Links
    NCBI Gene ID: 6330
    neXtProt AC: NX_Q8IWT1

  • Chr Location
    11q23.3; chr11:118133377-118152915 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 18384
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;2 zebrafish
  • HCOP
    human homology predictions: SCN4B
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human SCN4B associations

Human Disease Mouse Models
       Long QT Syndrome 10; LQT10   OMIM: 611819
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    1 phenotype reference
  • All Mutations and Alleles
    1
  • Targeted
    1
  • Incidental Mutations
Mice homozygous for a conditional ready allele are viable and fertile.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016701 VEGA Gene Model | MGI Sequence Detail 15716 C57BL/6J ±  kb
transcript OTTMUST00000040454 VEGA | MGI Sequence Detail 4940 Not Applicable  
polypeptide OTTMUSP00000018078 VEGA | MGI Sequence Detail 228 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    98 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 10
    Genomic 1
    cDNA 9

    Microarray probesets 2
Other
Accession IDs
less
MGI:2686317
References
more
  • Summaries
    All 24
    Gene Ontology 6
    Phenotypes 1
  • Earliest
    J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-15;
  • Latest
    J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory