Cdhr2 MGI Mouse Gene Detail - MGI:2687323 - cadherin-related family member 2

Symbol

Cdhr2
Name

cadherin-related family member 2
Synonyms

LOC268663, Pcdh24

Feature Type

protein coding gene
IDs

MGI:2687323
NCBI Gene: 268663
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr13:54849276-54884475 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 29.03 cM
Mapping Data

1 experiment

SNPs within 2kb

146 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2687323	protein coding gene	Chr13:54849274-54884475 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020577	protein coding gene	Chr13:54111937-54149823 (+)
A/J	MGP_AJ_G0020531	protein coding gene	Chr13:52127381-52162754 (+)
AKR/J	MGP_AKRJ_G0020509	protein coding gene	Chr13:53666291-53704164 (+)
BALB/cJ	MGP_BALBcJ_G0020527	protein coding gene	Chr13:52365271-52401604 (+)
C3H/HeJ	MGP_C3HHeJ_G0020326	protein coding gene	Chr13:53487720-53523553 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020961	protein coding gene	Chr13:55775767-55815371 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018543	protein coding gene	Chr13:50124568-50159079 (+)
CAST/EiJ	MGP_CASTEiJ_G0019840	protein coding gene	Chr13:53570443-53608241 (+)
CBA/J	MGP_CBAJ_G0020286	protein coding gene	Chr13:57889240-57931952 (+)
DBA/2J	MGP_DBA2J_G0020409	protein coding gene	Chr13:51695490-51730411 (+)
FVB/NJ	MGP_FVBNJ_G0020388	protein coding gene	Chr13:51145414-51183381 (+)
LP/J	MGP_LPJ_G0020485	protein coding gene	Chr13:54389992-54426708 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020417	protein coding gene	Chr13:57386155-57439878 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021004	protein coding gene	Chr13:53258770-53298281 (+)
PWK/PhJ	MGP_PWKPhJ_G0019596	protein coding gene	Chr13:51687348-51723683 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019423	protein coding gene	Chr13:52186654-52214540 (+)
WSB/EiJ	MGP_WSBEiJ_G0019902	protein coding gene	Chr13:53593089-53629541 (+)

Human Ortholog

CDHR2, cadherin related family member 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CDHR2, cadherin related family member 2
Synonyms

PCDH24, PCLCK, PCLKC
Links

HGNC:18231

NCBI Gene ID: 54825

neXtProt AC: NX_Q9BYE9

UniProt: Q9BYE9
Chr Location

5q35.2; chr5:176542511-176595768 (+) GRCh38.p7

Alliance of Genome Resources

Cdhr2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CDHR2
Gene Tree

Cdhr2

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References

1 with disease annotations

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Phenotype Summary

9 phenotypes from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Gene trapped

2
Targeted

4
Genomic Mutations

2 involving Cdhr2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

37 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

24
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

672
cDNA Data

20

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA CDHR2

Xenbase cdhr2

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Cdhr2 interacts with 54 markers (Mir15a, Mir32, Mir125a, ...) View All

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All Sequences

33
RefSeq

2
UniProt

2
CCDS

CCDS36669.1

Ensembl

ENSMUSG00000034918 (Evidence)
NCBI Gene

268663

			Length	Strain/Species	Flank
genomic	268663	NCBI Gene Model \| MGI Sequence Detail	35200	C57BL/6J	± kb
transcript	NM_001033364	RefSeq \| MGI Sequence Detail	4131	C57BL/6
polypeptide	E9Q7P9	UniProt \| EBI \| MGI Sequence Detail	1308	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000012352 cadherin-related family member 2

(term hierarchy)
PDB

5CYX
InterPro Domains

IPR039808 Cadherin

IPR020894 Cadherin conserved site

IPR002126 Cadherin-like

IPR015919 Cadherin-like superfamily

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All nucleic 20

cDNA 20

Microarray probesets 2

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MGI:2685470

Summaries

All 29

Diseases 1

Gene Ontology 4

Phenotypes 7
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:273165 Pinette JA, et al., Brush border protocadherin CDHR2 promotes the elongation and maximized packing of microvilli in vivo. Mol Biol Cell. 2019 Jan 1;30(1):108-118

TSS for Cdhr2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr119889	Chr13:54849248-54849259 (+)	-22 bp
Tssr119890	Chr13:54849270-54849292 (+)	5 bp
Tssr119891	Chr13:54865421-54865430 (+)	16,150 bp
Tssr119892	Chr13:54866373-54866385 (+)	17,103 bp
Tssr119893	Chr13:54867958-54867974 (+)	18,690 bp
Tssr119894	Chr13:54874604-54874615 (+)	25,334 bp
Tssr119895	Chr13:54878056-54878059 (+)	28,782 bp
Tssr119896	Chr13:54879531-54879541 (+)	30,260 bp
Tssr119897	Chr13:54879588-54879603 (+)	30,320 bp
Tssr4074	Chr13:54879632-54879641 (+)	30,361 bp
Tssr119898	Chr13:54879842-54879866 (+)	30,578 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 08/03/2022 MGI 6.21