Cdhr2 Gene Detail

Summary

• Symbol
  Cdhr2
• Name
  cadherin-related family member 2
• Synonyms
  LOC268663, Pcdh24

• Feature Type
  protein coding gene
• IDs
  MGI:2687323
  NCBI Gene: 268663
• Gene Overview
  MyGene.info: CDHR2
• Alliance
  gene page
• Transcription Start Sites
  3 TSS

Location &
Maps

• Sequence Map
  Chr13:54701463-54736662 bp, + strand
• From NCBI annotation of GRCm38
  

  View this region in JBrowse
  
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 13, 29.03 cM
• Mapping Data
  1 experiment

Strain
Comparison

• SNPs within 2kb
  146 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2687323	protein coding gene	Chr13:54701461-54736662 (.)
129S1/SvImJ	MGP_129S1SvImJ_G0020577	protein coding gene	Chr13:54111937-54149823 (+)
A/J	MGP_AJ_G0020531	protein coding gene	Chr13:52127381-52162754 (+)
AKR/J	MGP_AKRJ_G0020509	protein coding gene	Chr13:53666291-53704164 (+)
BALB/cJ	MGP_BALBcJ_G0020527	protein coding gene	Chr13:52365271-52401604 (+)
C3H/HeJ	MGP_C3HHeJ_G0020326	protein coding gene	Chr13:53487720-53523553 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020961	protein coding gene	Chr13:55775767-55815371 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018543	protein coding gene	Chr13:50124568-50159079 (+)
CAST/EiJ	MGP_CASTEiJ_G0019840	protein coding gene	Chr13:53570443-53608241 (+)
CBA/J	MGP_CBAJ_G0020286	protein coding gene	Chr13:57889240-57931952 (+)
DBA/2J	MGP_DBA2J_G0020409	protein coding gene	Chr13:51695490-51730411 (+)
FVB/NJ	MGP_FVBNJ_G0020388	protein coding gene	Chr13:51145414-51183381 (+)
LP/J	MGP_LPJ_G0020485	protein coding gene	Chr13:54389992-54426708 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020417	protein coding gene	Chr13:57386155-57439878 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021004	protein coding gene	Chr13:53258770-53298281 (+)
PWK/PhJ	MGP_PWKPhJ_G0019596	protein coding gene	Chr13:51687348-51723683 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019423	protein coding gene	Chr13:52186654-52214540 (+)
WSB/EiJ	MGP_WSBEiJ_G0019902	protein coding gene	Chr13:53593089-53629541 (+)

Homology

• Human Ortholog
  CDHR2, cadherin related family member 2

• Vertebrate Orthologs
  11

• Human Ortholog
  CDHR2, cadherin related family member 2
  Orthology source: HomoloGene, HGNC
• Synonyms
  PCDH24, PCLKC
• Links
  HGNC:18231

  NCBI Gene ID: 54825

  neXtProt AC: NX_Q9BYE9

  UniProt: Q9BYE9

  
  
• Chr Location
  5q35.2; chr5:176542511-176595768 (+)  GRCh38.p7

---

• HomoloGene
  Vertebrate Homology Class 134510
  1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  
• HCOP
  human homology predictions: CDHR2
• Gene Tree
  Cdhr2
  

Human Diseases

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  6 phenotype references
  

• All Mutations and Alleles
  6
• Chemically induced (other)
  1
• Gene trapped
  2
• Targeted
  3
• Genomic Mutations
  2 involving Cdhr2
• Incidental Mutations
  Mutagenetix , APF , CvDC
• Find Mice (IMSR)
  37 strains or lines available

Gene Ontology
(GO)
Classifications

• All GO Annotations
  25
• GO References
  5

• External Resources
  FuncBase

Expression

• cDNA Data
  20

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  GEISHA CDHR2
  Xenbase cdhr2

Interactions

• Cdhr2 interacts with 54 markers (Mir15a, Mir32, Mir125a, ...) View All

Sequences &
Gene Models

• All Sequences
  33
• RefSeq
  2
• UniProt
  2
• CCDS
  CCDS36669.1
• UniGene
  315382

• Ensembl
  ENSMUSG00000034918 (Evidence)
• NCBI Gene
  268663

Representative Sequences			Length	Strain/Species
genomic	268663	NCBI Gene Model | MGI Sequence Detail	35200	C57BL/6J
transcript	NM_001033364	RefSeq | MGI Sequence Detail	4131	C57BL/6
polypeptide	E9Q7P9	UniProt | EBI | MGI Sequence Detail	1308	Not Applicable

Protein
Information

• UniProt
  2 Sequences
• Protein Ontology
  PR:000012352 cadherin-related family member 2
  (term hierarchy)
• PDB
  5CYX
• InterPro Domains
  IPR020894 Cadherin conserved site
  IPR002126 Cadherin-like
  IPR015919 Cadherin-like superfamily
  IPR030276 Cadherin-related family member 2

Molecular
Reagents

• All nucleic 20

  cDNA 20

  
  

  Microarray probesets 2

Other
Accession IDs

MGI:2685470

References

• Summaries
  All 29

  Diseases 1

  Gene Ontology 5

  Phenotypes 6
• Earliest
  J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
• Latest
  J:190741 Migdalska AM, et al., Generation of the Sotos syndrome deletion in mice. Mamm Genome. 2012 Dec;23(11-12):749-57

TSS for Cdhr2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr119889	Chr13:54701435-54701446 (+)	-22 bp
Tssr119890	Chr13:54701457-54701479 (+)	5 bp
Tssr119894	Chr13:54726791-54726802 (+)	25,334 bp