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Il1rapl1 Gene Detail
Summary
  • Symbol
    Il1rapl1
  • Name
    interleukin 1 receptor accessory protein-like 1
  • Synonyms
    6330532G10Rik, IL1R8, IL1RAPL, MRX34, OPHN4, TIGIRR-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2687319
    NCBI Gene: 331461
  • Gene Overview
    MyGene.info: IL1RAPL1
Location & Maps
more
  • Sequence Map
    ChrX:86740870-88115645 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      1374776 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome X, 39.89 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    IL1RAPL1, interleukin 1 receptor accessory protein like 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    IL1RAPL1, interleukin 1 receptor accessory protein like 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    IL1R8, IL1RAPL, MRX10, MRX21, MRX34, OPHN4, TIGIRR-2
  • Links
    NCBI Gene ID: 11141
    neXtProt AC: NX_Q9NZN1

  • Chr Location
    Xp22.1-p21.3; chrX:28587564-29956350 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human IL1RAPL1 associations

Human Disease Mouse Models
       Mental Retardation, X-Linked 21; MRX21   OMIM: 300143
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Targeted
    5
Mice homozygous for a knock-out allele exhibit premature giant inhibitory postsynaptic currents and parallel fiber-mediated recruitment of molecular layer interneurons.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016973 VEGA Gene Model | MGI Sequence Detail 1374776 C57BL/6J ±  kb
transcript OTTMUST00000041160 VEGA | MGI Sequence Detail 9133 Not Applicable  
polypeptide OTTMUSP00000018440 VEGA | MGI Sequence Detail 696 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    3542 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 7
    cDNA 7

    Microarray probesets 2
Other
Accession IDs
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MGI:1923412
References
more
  • Summaries
    All 31
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 6
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:222796 Yamagata A, et al., Mechanisms of splicing-dependent trans-synaptic adhesion by PTPdelta-IL1RAPL1/IL-1RAcP for synaptic differentiation. Nat Commun. 2015;6:6926

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory