About   Help   FAQ
Il1rapl1 Gene Detail
Summary
  • Symbol
    Il1rapl1
  • Name
    interleukin 1 receptor accessory protein-like 1
  • Synonyms
    6330532G10Rik, IL1R8, IL1RAPL, MRX34, OPHN4, TIGIRR-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2687319
    NCBI Gene: 331461
  • Gene Overview
    MyGene.info: IL1RAPL1
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:86747242-88115623 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 39.89 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3534 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2687319
protein coding gene ChrX:86740870-88115645 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035893
protein coding gene ChrX:82870121-84323837 (-)
A/J MGP_AJ_G0035879
protein coding gene ChrX:82958662-84364088 (-)
AKR/J MGP_AKRJ_G0035797
protein coding gene ChrX:85167270-86602663 (-)
BALB/cJ MGP_BALBcJ_G0035859
protein coding gene ChrX:81709298-83109325 (-)
C3H/HeJ MGP_C3HHeJ_G0035570
protein coding gene ChrX:83148219-84563792 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036390
protein coding gene ChrX:85431166-86870942 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033222
protein coding gene ChrX:81734079-83059407 (-)
CAST/EiJ MGP_CASTEiJ_G0034858
protein coding gene ChrX:68122290-69509554 (-)
CBA/J MGP_CBAJ_G0035545
protein coding gene ChrX:87742381-89295592 (-)
DBA/2J MGP_DBA2J_G0035699
protein coding gene ChrX:82376225-83760758 (-)
FVB/NJ MGP_FVBNJ_G0035639
protein coding gene ChrX:81750194-83142781 (-)
LP/J MGP_LPJ_G0035789
protein coding gene ChrX:83649863-85070716 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035675
protein coding gene ChrX:91295868-93257489 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036417
protein coding gene ChrX:82575564-83988510 (-)
PWK/PhJ MGP_PWKPhJ_G0034556
protein coding gene ChrX:66094938-67472767 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034387
protein coding gene ChrX:69043387-70521995 (-)
WSB/EiJ MGP_WSBEiJ_G0034997
protein coding gene ChrX:81484712-82904687 (-)



Homology
more
  • Human Ortholog
    IL1RAPL1, interleukin 1 receptor accessory protein like 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    IL1RAPL1, interleukin 1 receptor accessory protein like 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    IL1R8, IL1RAPL, IL-1-RAPL-1, IL-1RAPL-1, IL1RAPL-1, MRX10, MRX21, MRX34, OPHN4, TIGIRR-2
  • Links
    NCBI Gene ID: 11141
    neXtProt AC: NX_Q9NZN1
    UniProt: Q9NZN1

  • Chr Location
    Xp21.3-p21.2; chrX:28587564-29956350 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human IL1RAPL1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit premature giant inhibitory postsynaptic currents and parallel fiber-mediated recruitment of molecular layer interneurons.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 331461 NCBI Gene Model | MGI Sequence Detail 1368382 C57BL/6J ±  kb
    transcript NM_001160403 RefSeq | MGI Sequence Detail 2739 Not Specified  
    polypeptide P59823 UniProt | EBI | MGI Sequence Detail 695 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 8

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:1923412
    References
    more
    • Summaries
      All 32
      Developmental Gene Expression 2
      Gene Ontology 6
      Phenotypes 8
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:243287 Montani C, et al., The X-Linked Intellectual Disability Protein IL1RAPL1 Regulates Dendrite Complexity. J Neurosci. 2017 Jul 12;37(28):6606-6627

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory