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Pfkfb4 Gene Detail
Summary
  • Symbol
    Pfkfb4
  • Name
    6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
  • Feature Type
    protein coding gene
  • IDs
    MGI:2687284
    NCBI Gene: 270198
  • Gene Overview
    MyGene.info: PFKFB4
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:108991778-109032228 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 59.63 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    164 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2687284
protein coding gene Chr9:108988269-109032236 (.)
129S1/SvImJ MGP_129S1SvImJ_G0035320
protein coding gene Chr9:110939210-110988761 (+)
A/J MGP_AJ_G0035299
protein coding gene Chr9:106871578-106910012 (+)
AKR/J MGP_AKRJ_G0035231
protein coding gene Chr9:109553261-109595914 (+)
BALB/cJ MGP_BALBcJ_G0035293
protein coding gene Chr9:106567075-106610618 (+)
C3H/HeJ MGP_C3HHeJ_G0035003
protein coding gene Chr9:109949667-109994078 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035813
protein coding gene Chr9:113972778-114014137 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032711
protein coding gene Chr9:104276976-104315998 (+)
CAST/EiJ MGP_CASTEiJ_G0034314
protein coding gene Chr9:109924660-109965173 (+)
CBA/J MGP_CBAJ_G0034971
protein coding gene Chr9:117983688-118029514 (+)
DBA/2J MGP_DBA2J_G0035132
protein coding gene Chr9:106322227-106363034 (+)
FVB/NJ MGP_FVBNJ_G0035080
protein coding gene Chr9:105141545-105181915 (+)
LP/J MGP_LPJ_G0035208
protein coding gene Chr9:111130063-111174236 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035119
protein coding gene Chr9:119539152-119581377 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035834
protein coding gene Chr9:109826513-109868172 (+)
PWK/PhJ MGP_PWKPhJ_G0034021
protein coding gene Chr9:106658818-106697684 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033856
protein coding gene Chr9:109896271-109935529 (+)
WSB/EiJ MGP_WSBEiJ_G0034435
protein coding gene Chr9:109725832-109768867 (+)



Homology
more
  • Human Ortholog
    PFKFB4, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
  • Vertebrate Orthologs
    11
  • Human Ortholog
    PFKFB4, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 5210
    neXtProt AC: NX_Q16877
    UniProt: Q16877

  • Chr Location
    3p21.31; chr3:48517684-48562383 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025648 Ensembl Gene Model | MGI Sequence Detail 40451 C57BL/6J ±  kb
    transcript ENSMUST00000198140 Ensembl | MGI Sequence Detail 3488 Not Applicable  
    polypeptide ENSMUSP00000142378 Ensembl | MGI Sequence Detail 469 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 31
      cDNA 31

      Microarray probesets 3
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 3
      Gene Ontology 7
      Phenotypes 6
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory