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N4bp2l2 Gene Detail
Summary
  • Symbol
    N4bp2l2
  • Name
    NEDD4 binding protein 2-like 2
  • Synonyms
    2700092H06Rik, MGC:25830, zag1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2687207
    NCBI Gene: 381695
Location & Maps
more
  • Sequence Map
    Chr5:150608007-150666183 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      58177 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    N4BP2L2, NEDD4 binding protein 2-like 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    N4BP2L2, NEDD4 binding protein 2-like 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    92M18.3, CG005, PFAAP5
  • Links
    NCBI Gene ID: 10443
    neXtProt AC: NX_Q92802

  • Chr Location
    13q13.1; chr13:32432488-32538885 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotype references
  • All Mutations and Alleles
    22
  • Gene trapped
    20
  • Targeted
    2
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027925 VEGA Gene Model | MGI Sequence Detail 58177 C57BL/6J ±  kb
transcript OTTMUST00000069171 VEGA | MGI Sequence Detail 8982 Not Applicable  
polypeptide OTTMUSP00000035096 VEGA | MGI Sequence Detail 575 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    235 from dbSNP Build 137
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000010940 NEDD4-binding protein 2-like 2
  • InterPro Domains
    IPR026568 NEDD4-binding protein 2-like 2
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
Molecular
Reagents
less
  • All nucleic 48
    cDNA 48

    Microarray probesets 3
Other
Accession IDs
less
MGI:1925575
References
more
  • Summaries
    All 31
    Gene Ontology 3
    Phenotypes 7
  • Earliest
    J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
  • Latest
    J:205673 Salipante SJ, et al., Contributions to neutropenia from PFAAP5 (N4BP2L2), a novel protein mediating transcriptional repressor cooperation between Gfi1 and neutrophil elastase. Mol Cell Biol. 2009 Aug;29(16):4394-405

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory