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Lypd4 Gene Detail
Summary
  • Symbol
    Lypd4
  • Name
    Ly6/Plaur domain containing 4
  • Synonyms
    4933400F01Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2687054
    NCBI Gene: 232973
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:24564044-24569180 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 13.30 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    5 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2687054
 protein coding gene Chr7:24564044-24569366 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031844
 protein coding gene Chr7:23275030-23280347 (-)
A/J MGP_AJ_G0031823
 protein coding gene Chr7:22701550-22706855 (-)
AKR/J MGP_AKRJ_G0031752
 protein coding gene Chr7:23228869-23234184 (-)
BALB/cJ MGP_BALBcJ_G0031831
 protein coding gene Chr7:22905393-22912438 (-)
C3H/HeJ MGP_C3HHeJ_G0031549
 protein coding gene Chr7:23645344-23650339 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032292
 protein coding gene Chr7:24044280-24049703 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029347
 protein coding gene Chr7:24135744-24140897 (-)
CAST/EiJ MGP_CASTEiJ_G0030889
 protein coding gene Chr7:17121909-17128740 (-)
CBA/J MGP_CBAJ_G0031514
 protein coding gene Chr7:24924080-24929077 (-)
DBA/2J MGP_DBA2J_G0031668
 protein coding gene Chr7:22606465-22611657 (-)
FVB/NJ MGP_FVBNJ_G0031621
 protein coding gene Chr7:22582230-22587219 (-)
LP/J MGP_LPJ_G0031747
 protein coding gene Chr7:23583255-23589871 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031658
 protein coding gene Chr7:24666683-24672372 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032324
 protein coding gene Chr7:22932694-22938145 (-)
PWK/PhJ MGP_PWKPhJ_G0030613
 protein coding gene Chr7:17534972-17540359 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030444
 protein coding gene Chr7:14244056-14249282 (-)
WSB/EiJ MGP_WSBEiJ_G0030993
 protein coding gene Chr7:23089622-23095223 (-)



Homology
more
  • Human Ortholog
    LYPD4, LY6/PLAUR domain containing 4
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LYPD4, LY6/PLAUR domain containing 4
  • Synonyms
    SMR
  • Links
    NCBI Gene ID: 147719
    neXtProt AC: NX_Q6UWN0
    UniProt: Q6UWN0

  • Chr Location
    19q13.2; chr19:41835075-41844871 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit impaired sperm migration in the female genital tract and impaired binding of sperm to the zona pellucida, leading to fertilization failure and male infertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    2
  • GO References
    2
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    15
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 232973 NCBI Gene Model | MGI Sequence Detail 5137 C57BL/6J ±  kb
    transcript NM_001419266 RefSeq | MGI Sequence Detail 1200 C57BL/6  
    polypeptide Q8BVP6 UniProt | EBI | MGI Sequence Detail 246 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 15

      Microarray probesets 2
    References
    more
    • Summaries
      All 25
      Gene Ontology 2
      Phenotypes 5
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:294725 Wang D, et al., LYPD4, mouse homolog of a human acrosome protein, is essential for sperm fertilizing ability and male fertility. Biol Reprod. 2020 Apr 24;102(5):1033-1044
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory