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Inpp5a
Gene Detail
 Symbol
Name
ID
Inpp5a
inositol polyphosphate-5-phosphatase A
MGI:2686961
Feature Type protein coding gene
Genetic Map
Chromosome 7
84.57 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr7:139389109-139579652 bp, + strand
From VEGA annotation of GRCm38

  190544 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4045  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Inpp5a

Human
homologs
Human Homolog INPP5A, inositol polyphosphate-5-phosphatase, 40kDa
NCBI Gene ID 3632
neXtProt AC  NX_Q14642
Human Synonyms  5PTASE
Human Chr (Location)  10q26.3; chr10:132537849-132783480 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Gene trapped(1) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in lethality before weaning.
 
Interactions
Inpp5a interacts with 218 markers (Mir7-1, Mir10a, Mir15a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Process inositol phosphate dephosphorylation
Component extracellular vesicular exosome, membrane
Function inositol-polyphosphate 5-phosphatase activity, PH domain binding
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (127)    Tissues (98)    Images (25)
Theiler Stages: 22, 23
Assay TypeResults
RNA in situ 127
cDNA source data(11)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(11) cDNA(11)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000024504 (Evidence)
Ensembl Gene ModelENSMUSG00000025477 (Evidence)
Entrez Gene212111 (Evidence)
NIA Mouse Gene IndexU008904
Consensus CDS ProjectCCDS21954.1, CCDS52428.1
International Mouse Knockout Project StatusInpp5a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024504 VEGA Gene Model | MGI Sequence Detail 190544 C57BL/6J ±  kb
transcript OTTMUST00000060127 VEGA | MGI Sequence Detail 2774 Not Applicable 
polypeptide OTTMUSP00000029320 VEGA | MGI Sequence Detail 422 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(8) UniProt(4)
Polymorphisms SNPs within 2kb(884 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005135 Endonuclease/exonuclease/phosphatase
InterPro IPR000300 Inositol polyphosphate-related phosphatase
Protein Ontology PR:000009047 type I inositol 1,4,5-trisphosphate 5-phosphatase
References (Earliest) J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(27)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory