Inpp5a
Gene Detail

Symbol Name ID

Inpp5a inositol polyphosphate-5-phosphatase A MGI:2686961

Feature Type

protein coding gene

Genetic Map

Chromosome 7

84.57 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr7:139389109-139579652 bp, + strand From VEGA annotation of GRCm38   190544 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Inpp5a ± 2 cM)

Gene Tree: Inpp5a

Human ortholog

INPP5A inositol polyphosphate-5-phosphatase, 40kDa NCBI Gene ID 3632
Human Synonyms: 5PTASE
Human Chr10:134351353-134596984 bp, + strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(3) : Targeted(2) Gene trapped(1)
 

Homozygous mutation of this gene results in lethality before weaning.

 

Gene Ontology (GO) classifications

All GO classifications: (4 annotations)

Process	inositol phosphate dephosphorylation
Component	membrane
Function	inositol-polyphosphate 5-phosphatase activity, PH domain binding

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (127)    Tissues (98)    Images (25)
Theiler Stages: 22, 23

Assay Type	Results
RNA in situ	127

cDNA source data(11)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(11) cDNA(11)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000024504 (Evidence)
Ensembl Gene Model	ENSMUSG00000025477 (Evidence)
Entrez Gene	212111 (Evidence)
NIA Mouse Gene Index	U008904
Consensus CDS Project	CCDS21954.1, CCDS52428.1
International Mouse Knockout Project Status	Inpp5a

Sequences

Length	Strain/Species
genomic	OTTMUSG00000024504	VEGA Gene Model | MGI Sequence Detail	190544	C57BL/6J
transcript	OTTMUST00000060127	VEGA | MGI Sequence Detail	2767	Not Applicable
polypeptide	OTTMUSP00000029320	VEGA | MGI Sequence Detail	422	Not Applicable

All sequences(43) RefSeq(4) UniProt(4)

Polymorphisms

SNPs(703 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR005135	Endonuclease/exonuclease/phosphatase
InterPro	IPR000300	Inositol polyphosphate-related phosphatase

References

(Earliest) J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(26)