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Inpp5a Gene Detail
Summary
  • Symbol
    Inpp5a
  • Name
    inositol polyphosphate-5-phosphatase A
  • Feature Type
    protein coding gene
  • IDs
    MGI:2686961
    NCBI Gene: 212111
  • Gene Overview
    MyGene.info: INPP5A
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:139389109-139579652 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 84.57 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    883 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2686961
protein coding gene Chr7:139389109-139579652 (.)
129S1/SvImJ MGP_129S1SvImJ_G0033150
protein coding gene Chr7:144407922-144610058 (+)
A/J MGP_AJ_G0033132
protein coding gene Chr7:140327784-140525565 (+)
AKR/J MGP_AKRJ_G0033064
protein coding gene Chr7:144122214-144331030 (+)
BALB/cJ MGP_BALBcJ_G0033133
protein coding gene Chr7:140072721-140267304 (+)
C3H/HeJ MGP_C3HHeJ_G0032847
protein coding gene Chr7:143937999-144142376 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033644
protein coding gene Chr7:149748493-149946896 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030617
protein coding gene Chr7:141470084-141656827 (+)
CAST/EiJ MGP_CASTEiJ_G0032177
protein coding gene Chr7:136224984-136433543 (+)
CBA/J MGP_CBAJ_G0032820
protein coding gene Chr7:154795402-155007519 (+)
DBA/2J MGP_DBA2J_G0032972
protein coding gene Chr7:138285182-138481301 (+)
FVB/NJ MGP_FVBNJ_G0032925
protein coding gene Chr7:138172892-138365466 (+)
LP/J MGP_LPJ_G0033066
protein coding gene Chr7:145959931-146159718 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032957
protein coding gene Chr7:155487492-155698599 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033664
protein coding gene Chr7:143120300-143321679 (+)
PWK/PhJ MGP_PWKPhJ_G0031883
protein coding gene Chr7:131460085-131653001 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031728
protein coding gene Chr7:129950948-130158523 (+)
WSB/EiJ MGP_WSBEiJ_G0032288
protein coding gene Chr7:144042446-144238571 (+)



Homology
more
  • Human Ortholog
    INPP5A, inositol polyphosphate-5-phosphatase A
  • Vertebrate Orthologs
    9
  • Human Ortholog
    INPP5A, inositol polyphosphate-5-phosphatase A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    5PTASE
  • Links
    NCBI Gene ID: 3632
    neXtProt AC: NX_Q14642
    UniProt: Q14642

  • Chr Location
    10q26.3; chr10:132537779-132783480 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Most mice homozygous for a gene trapped allele show preweaning lethality, while surviving mice exhibit decreased body size, small cerebellum, and early-onset, slowly progressive Purkinje cell degeneration, gliosis, and ataxia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 212111 NCBI Gene Model | MGI Sequence Detail 190544 C57BL/6J ±  kb
    transcript NM_001127363 RefSeq | MGI Sequence Detail 2843 C57BL/6  
    polypeptide NP_898967 RefSeq | MGI Sequence Detail 422 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • InterPro Domains
      IPR005135 Endonuclease/exonuclease/phosphatase
      IPR036691 Endonuclease/exonuclease/phosphatase superfamily
      IPR000300 Inositol polyphosphate-related phosphatase
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 12

      Microarray probesets 4
    References
    more
    • Summaries
      All 29
      Developmental Gene Expression 4
      Gene Ontology 4
      Phenotypes 7
    • Earliest
      J:65007 Cattanach BM, et al., Two imprinted gene mutations: three phenotypes. Hum Mol Genet. 2000 Sep 22;9(15):2263-73
    • Latest
      J:249381 Yang AW, et al., Deletion of Inpp5a causes ataxia and cerebellar degeneration in mice. Neurogenetics. 2015 Oct;16(4):277-85

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory