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Klhl6
Gene Detail
 Symbol
Name
ID
Klhl6
kelch-like 6
MGI:2686922
Feature Type protein coding gene
Genetic Map
Chromosome 16
12.32 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr16:19946499-19983037 bp, - strand
From VEGA annotation of GRCm38

  36539 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:15603  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: kelch-like protein, gigaxonin type
Gene Tree: Klhl6

Human
homologs
Human Homolog KLHL6, kelch-like family member 6
NCBI Gene ID 89857
neXtProt AC  NX_Q8WZ60
Human Chr (Location)  3q27.3; chr3:183487531-183555711 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Chemically induced (ENU)(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit spleen hypoplasia, defects in mature B-cell subsets with normal pro- and pre-B-cell development, severely impaired antigen-dependent germinal center formation, and reduced memory IgG response.
 
Interactions
Klhl6 interacts with 106 markers (Mir1a-1, Mir1a-2, Mir15a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (4 annotations)
Process B cell receptor signaling pathway, germinal center formation
Component cellular_component
Function molecular_function
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (9)    Tissues (5)    Images (10)
Theiler Stages: 12, 13, 23
Assay TypeResults
RNA in situ 9
cDNA source data(23)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(24) cDNA(24)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000035230 (Evidence)
Ensembl Gene ModelENSMUSG00000043008 (Evidence)
Entrez Gene239743 (Evidence)
UniGene86699
DFCITC1583310
DoTSDT.487091
NIA Mouse Gene IndexU036879
Consensus CDS ProjectCCDS28041.2
International Mouse Knockout Project StatusKlhl6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035230 VEGA Gene Model | MGI Sequence Detail 36539 C57BL/6J ±  kb
transcript OTTMUST00000089800 VEGA | MGI Sequence Detail 2386 Not Applicable 
polypeptide OTTMUSP00000049109 VEGA | MGI Sequence Detail 619 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(2) UniProt(3)
Polymorphisms SNPs within 2kb(160 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011705 BTB/Kelch-associated
InterPro IPR013069 BTB/POZ
InterPro IPR011333 BTB/POZ fold
InterPro IPR000210 BTB/POZ-like
InterPro IPR017096 Kelch-like protein, gigaxonin
InterPro IPR006652 Kelch repeat type 1
InterPro IPR015915 Kelch-type beta propeller
Protein Ontology PR:000009402 kelch-like protein 6
References (Earliest) J:87056 Gupta-Rossi N, et al., Specific over-expression of deltex and a new Kelch-like protein in human germinal center B cells. Mol Immunol. 2003 Mar;39(13):791-9
(Latest) J:176969 Costello I, et al., The T-box transcription factor Eomesodermin acts upstream of Mesp1 to specify cardiac mesoderm during mouse gastrulation. Nat Cell Biol. 2011 Sep;13(9):1084-91
All references(29)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory