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Klhl6
Gene Detail
Symbol

Name
ID
Klhl6
kelch-like 6
MGI:2686922
Feature Type
protein coding gene
Genetic Map
Chromosome 16
12.32 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr16:19946499-19983037 bp, - strand
From VEGA annotation of GRCm38

  36539 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:15603  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: KLHL6
Protein SuperFamily: kelch-like protein, gigaxonin type
Gene Tree: Klhl6

Human
homologs
KLHL6, kelch-like family member 6
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 89857
neXtProt AC: NX_Q8WZ60

Human Chr (Location): 3q27.3; chr3:183487531-183555712 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Chemically induced (ENU)(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit spleen hypoplasia, defects in mature B-cell subsets with normal pro- and pre-B-cell development, severely impaired antigen-dependent germinal center formation, and reduced memory IgG response.
 
Interactions
Klhl6 interacts with 106 markers (Mir1a-1, Mir1a-2, Mir15a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (4 annotations)
Process B cell receptor signaling pathway, germinal center formation
Component cellular_component
Function molecular_function
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (9)    Tissues (5)    Images (10)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 9
cDNA source data(23)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase klhl6    NEW 
Molecular
reagents
All nucleic(24) cDNA(24)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000035230 (Evidence)
Ensembl Gene Model ENSMUSG00000043008 (Evidence)
Entrez Gene 239743 (Evidence)
UniGene 86699
DFCI TC1583310
DoTS DT.487091
NIA Mouse Gene Index U036879
Consensus CDS Project CCDS28041.2
International Mouse Phenotyping Consortium Status Klhl6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035230 VEGA Gene Model | MGI Sequence Detail 36539 C57BL/6J ±  kb
transcript OTTMUST00000089800 VEGA | MGI Sequence Detail 2386 Not Applicable 
polypeptide OTTMUSP00000049109 VEGA | MGI Sequence Detail 619 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(160 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011705 BTB/Kelch-associated
InterPro IPR013069 BTB/POZ
InterPro IPR011333 BTB/POZ fold
InterPro IPR000210 BTB/POZ-like
InterPro IPR017096 Kelch-like protein, gigaxonin
InterPro IPR006652 Kelch repeat type 1
InterPro IPR015915 Kelch-type beta propeller
Protein Ontology PR:000009402 kelch-like protein 6
References
(Earliest) J:87056 Gupta-Rossi N, et al., Specific over-expression of deltex and a new Kelch-like protein in human germinal center B cells. Mol Immunol. 2003 Mar;39(13):791-9
(Latest) J:176969 Costello I, et al., The T-box transcription factor Eomesodermin acts upstream of Mesp1 to specify cardiac mesoderm during mouse gastrulation. Nat Cell Biol. 2011 Sep;13(9):1084-91
All references(27)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory