Nicol1 MGI Mouse Gene Detail - MGI:2686519 - NELL2 interacting cell ontogeny regulator 1

Symbol

Nicol1
Name

NELL2 interacting cell ontogeny regulator 1
Synonyms

Gm1673, LOC381633

Feature Type

protein coding gene
IDs

MGI:2686519
NCBI Gene: 381633
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr5:34140863-34142353 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 17.83 cM
Mapping Data

1 experiment

SNPs within 2kb

97 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2686519	protein coding gene	Chr5:34140777-34142357 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029456	protein coding gene	Chr5:32185837-32187417 (+)
A/J	MGP_AJ_G0029423	protein coding gene	Chr5:31133510-31135100 (+)
AKR/J	MGP_AKRJ_G0029372	protein coding gene	Chr5:32334499-32336089 (+)
BALB/cJ	MGP_BALBcJ_G0029433	protein coding gene	Chr5:31659996-31661586 (+)
C3H/HeJ	MGP_C3HHeJ_G0029155	protein coding gene	Chr5:32367882-32369472 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029887	protein coding gene	Chr5:34072464-34074044 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027124	protein coding gene	Chr5:28930381-28931955 (+)
CAST/EiJ	MGP_CASTEiJ_G0028564	protein coding gene	Chr5:31449919-31451509 (+)
CBA/J	MGP_CBAJ_G0029123	protein coding gene	Chr5:34799689-34801279 (+)
DBA/2J	MGP_DBA2J_G0029271	protein coding gene	Chr5:31316378-31317968 (+)
FVB/NJ	MGP_FVBNJ_G0029230	protein coding gene	Chr5:30743987-30745567 (+)
LP/J	MGP_LPJ_G0029356	protein coding gene	Chr5:32607401-32608981 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029260	protein coding gene	Chr5:35675052-35676632 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029920	protein coding gene	Chr5:31851373-31852953 (+)
PWK/PhJ	MGP_PWKPhJ_G0028289	protein coding gene	Chr5:30447942-30449522 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028120	protein coding gene	Chr5:31306958-31308551 (+)
WSB/EiJ	MGP_WSBEiJ_G0028645	protein coding gene	Chr5:31925394-31926984 (+)

Human Ortholog

NICOL1, NELL2 interacting cell ontogeny regulator 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NICOL1, NELL2 interacting cell ontogeny regulator 1
Synonyms

C4orf48, CHR4_55, NICOL
Links

HGNC:34437

NCBI Gene ID: 401115

UniProt: Q5BLP8
Chr Location

4p16.3; chr4:2036554-2043964 (+) GRCh38

MGI Vertebrate Homology

Nicol1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NICOL1
Gene Tree

Nicol1

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References

1 with disease annotations

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
30 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

23
Chemically induced (ENU)

1
Chemically induced (other)

2
Endonuclease-mediated

5
Gene trapped

5
Radiation induced

5
Spontaneous

1
Targeted

2
Transgenic

2
Genomic Mutations

9 involving Nicol1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

18 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit male infertility with epididymis degeneration, impaired sperm migration in female genital tract, impaired binding of sperm to zona pellucida, and decreased fertilization frequency.

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All GO Annotations

2
GO References

1

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

7

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase nicol1

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All Sequences

45
RefSeq

6
UniProt

2
CCDS

CCDS19209.2, CCDS80261.1

Ensembl

ENSMUSG00000070858 (Evidence)
NCBI Gene

381633

			Length	Strain/Species	Flank
genomic	381633	NCBI Gene Model \| MGI Sequence Detail	1491	C57BL/6J	± kb
transcript	NM_001310547	RefSeq \| MGI Sequence Detail	466	C57BL/6
polypeptide	Q3UR78	UniProt \| EBI \| MGI Sequence Detail	90	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000033622 NELL2-interacting cell ontogeny regulator 1

(term hierarchy)
InterPro Domains

IPR028147 NELL2-interacting cofactor for lumicrine signalling

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All nucleic 7

cDNA 7

Microarray probesets 1

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MGI:7524430

Summaries

All 46

Diseases 1

Gene Ontology 1

Phenotypes 30
Earliest

J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
Latest

J:349399 Yang J, et al., The secreted micropeptide C4orf48 enhances renal fibrosis via an RNA-binding mechanism. J Clin Invest. 2024 Apr 16;134(10)

TSS for Nicol1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr45840	Chr5:34140434-34140444 (+)	-424 bp
Tssr45841	Chr5:34140823-34140873 (+)	-15 bp
Tssr45842	Chr5:34140881-34140892 (+)	24 bp
Tssr45843	Chr5:34141019-34141053 (+)	173 bp
Tssr45844	Chr5:34141059-34141078 (+)	206 bp
Tssr45845	Chr5:34141085-34141094 (+)	227 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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