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Meioc Gene Detail
Summary
  • Symbol
    Meioc
  • Name
    meiosis specific with coiled-coil domain
  • Synonyms
    Gm1564, LOC268491, LOC380729
  • Feature Type
    protein coding gene
  • IDs
    MGI:2686410
    NCBI Gene: 268491
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:102664966-102682240 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 66.48 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    74 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2686410
protein coding gene Chr11:102663716-102682240 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019241
protein coding gene Chr11:105668970-105689616 (+)
A/J MGP_AJ_G0019209
protein coding gene Chr11:101198121-101216710 (+)
AKR/J MGP_AKRJ_G0019178
protein coding gene Chr11:104334975-104353496 (+)
BALB/cJ MGP_BALBcJ_G0019183
protein coding gene Chr11:101680754-101699550 (+)
C3H/HeJ MGP_C3HHeJ_G0018992
protein coding gene Chr11:104536824-104555285 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019632
protein coding gene Chr11:108954695-108975225 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017258
protein coding gene Chr11:98626669-98648484 (+)
CAST/EiJ MGP_CASTEiJ_G0018546
protein coding gene Chr11:105540465-105560481 (+)
CBA/J MGP_CBAJ_G0018961
protein coding gene Chr11:113449554-113472097 (+)
DBA/2J MGP_DBA2J_G0019073
protein coding gene Chr11:100713577-100731991 (+)
FVB/NJ MGP_FVBNJ_G0019063
protein coding gene Chr11:100255899-100274284 (+)
LP/J MGP_LPJ_G0019142
protein coding gene Chr11:106193025-106213046 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019094
protein coding gene Chr11:112930885-112948833 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019670
protein coding gene Chr11:104694249-104723232 (+)
PWK/PhJ MGP_PWKPhJ_G0018309
protein coding gene Chr11:101782042-101811491 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018101
protein coding gene Chr11:104458429-104476841 (+)
WSB/EiJ MGP_WSBEiJ_G0018595
protein coding gene Chr11:104695634-104717283 (+)



Homology
more
  • Human Ortholog
    MEIOC, meiosis specific with coiled-coil domain
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MEIOC, meiosis specific with coiled-coil domain
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C17orf104
  • Links
    NCBI Gene ID: 284071
    neXtProt AC: NX_A2RUB1
    UniProt: A2RUB1

  • Chr Location
    17q21.31; chr17:44656394-44677086 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 2 alleles in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit infertility with small gonads, absent germ cells and arrested meiosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 268491 NCBI Gene Model | MGI Sequence Detail 17275 C57BL/6J ±  kb
transcript NM_001127576 RefSeq | MGI Sequence Detail 4577 C57BL/6  
polypeptide A2AG06 UniProt | EBI | MGI Sequence Detail 965 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    2 Sequences
  • InterPro Domains
    IPR027963 Meiosis-specific coiled-coil domain-containing protein MEIOC
Molecular
Reagents
less
  • All nucleic 14
    Genomic 2
    cDNA 12

    Microarray probesets 2
Other
Accession IDs
less
MGI:2685509
References
more
  • Summaries
    All 29
    Developmental Gene Expression 2
    Gene Ontology 6
    Phenotypes 9
  • Earliest
    J:56548 Zheng B, et al., Engineering a mouse balancer chromosome. Nat Genet. 1999 Aug;22(4):375-8
  • Latest
    J:243742 Wojtas MN, et al., Regulation of m(6)A Transcripts by the 3'-->5' RNA Helicase YTHDC2 Is Essential for a Successful Meiotic Program in the Mammalian Germline. Mol Cell. 2017 Oct 19;68(2):374-387.e12

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
05/14/2019
MGI 6.14
The Jackson Laboratory