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Frmd7
Gene Detail
Symbol

Name
ID
Frmd7
FERM domain containing 7
MGI:2686379
Synonyms
EG665849, LOC385354
Feature Type
protein coding gene
Genetic Map
Chromosome X
27.82 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
ChrX:50895180-50942710 bp, - strand
From VEGA annotation of GRCm38

  47531 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:18855  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: FRMD7
Gene Tree: Frmd7

Human
homologs
FRMD7, FERM domain containing 7
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 90167
neXtProt AC: NX_Q6ZUT3

Human Synonyms: NYS, NYS1, XIPAN

Human Chr (Location): Xq26.2; chrX:132076993-132128022 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human FRMD7

Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Interactions
Frmd7 interacts with 328 markers (Mir1b, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process negative regulation of protein binding, negative regulation of stress fiber assembly, ...
Component cell projection, cytoskeleton, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (51)    Tissues (43)    Images (3)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 6
Western blot 9
RT-PCR 36
cDNA source data(3)
Other mouse links: GEO   Expression Atlas
Other vertebrate links: Xenbase frmd7    NEW 
Molecular
reagents
All nucleic(4) cDNA(3) Primer pair(1)
Microarray probesets(1)
Other database
links
VEGA Gene Model OTTMUSG00000017472 (Evidence)
Ensembl Gene Model ENSMUSG00000036131 (Evidence)
Entrez Gene 385354 (Evidence)
UniGene 393050
DoTS DT.530334
NIA Mouse Gene Index U053729
Consensus CDS Project CCDS53067.1
International Mouse Phenotyping Consortium Status Frmd7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017472 VEGA Gene Model | MGI Sequence Detail 47531 C57BL/6J ±  kb
transcript OTTMUST00000042424 VEGA | MGI Sequence Detail 2112 Not Applicable 
polypeptide OTTMUSP00000019068 VEGA | MGI Sequence Detail 703 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(15) UniProt(2)
Polymorphisms
SNPs within 2kb(140 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR019749 Band 4.1 domain
InterPro IPR014352 FERM/acyl-CoA-binding protein, 3-helical bundle
InterPro IPR014847 FERM adjacent (FA)
InterPro IPR019748 FERM central domain
InterPro IPR019747 FERM conserved site
InterPro IPR018980 FERM, C-terminal PH-like domain
InterPro IPR000299 FERM domain
InterPro IPR018979 FERM, N-terminal
InterPro IPR011993 Pleckstrin homology-like domain
Protein Ontology PR:000007667 FERM domain-containing protein 7
References
(Earliest) J:155331 Betts-Henderson J, et al., The nystagmus-associated FRMD7 gene regulates neuronal outgrowth and development. Hum Mol Genet. 2010 Jan 15;19(2):342-51
(Latest) J:205847 Pu J, et al., FERM domain containing protein 7 interacts with the Rho GDP dissociation inhibitor and specifically activates Rac1 signaling. PLoS One. 2013;8(8):e73108
All references(25)
Other
accession IDs
MGI:3643612

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory