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Frmd7 Gene Detail
Summary
  • Symbol
    Frmd7
  • Name
    FERM domain containing 7
  • Synonyms
    EG665849, LOC385354
  • Feature Type
    protein coding gene
  • IDs
    MGI:2686379
    NCBI Gene: 385354
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:49984057-50031587 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 27.82 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    959 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2686379
 protein coding gene ChrX:49980044-50032493 (-)
129S1/SvImJ ENSMUSG00200037229
 protein coding gene ChrX:33824506-33872040 (-)
A/J ENSMUSG00195015745
 protein coding gene ChrX:36629309-36676871 (-)
AKR/J ENSMUSG00220035650
 protein coding gene ChrX:33488765-33536315 (-)
BALB/cJ ENSMUSG00180031483
 protein coding gene ChrX:34343850-34391396 (-)
C3H/HeJ ENSMUSG00175038675
 protein coding gene ChrX:37363177-37410723 (-)
C57BL/6NJ ENSMUSG00215046081
 protein coding gene ChrX:34371262-34418798 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033059
 protein coding gene ChrX:43485658-43531252 (-)
CAST/EiJ ENSTCUG00005037765
 protein coding gene ChrX:36339660-36387337 (-)
CBA/J ENSMUSG00210039030
 protein coding gene ChrX:34605955-34653502 (-)
DBA/2J ENSMUSG00185033394
 protein coding gene ChrX:45311752-45359301 (-)
FVB/NJ ENSMUSG00205029264
 protein coding gene ChrX:32964965-33012511 (-)
JF1/MsJ ENSUMUG00000016871
 protein coding gene ChrX:64352619-64399384 (-)
LP/J ENSMUSG00230029170
 protein coding gene ChrX:51844611-51892150 (-)
NOD/ShiLtJ ENSMUSG00190035428
 protein coding gene ChrX:33705157-33752697 (-)
NZO/HlLtJ ENSMUSG00225042543
 protein coding gene ChrX:57038222-57085765 (-)
PWK/PhJ ENSLUMG00010041008
 protein coding gene ChrX:34047421-34094213 (-)
SPRET/EiJ ENSMSPG00010023012
 protein coding gene ChrX:35734259-35784521 (-)
WSB/EiJ ENSIUOG00005045173
 protein coding gene ChrX:34881918-34929436 (-)



Homology
more
  • Human Ortholog
    FRMD7, FERM domain containing 7
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FRMD7, FERM domain containing 7
  • Synonyms
    NYS, NYS1, XIPAN
  • Links
    NCBI Gene ID: 90167
    UniProt: Q6ZUT3

  • Chr Location
    Xq26.2; chrX:132076990-132128020 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Frmd7 mouse models; 1 with human FRMD7 associations

Human Disease Mouse Models
      
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele lack an optokinetic reflex in the horizontal direction.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    650
  • Tissues
    43
  • cDNA Data
    3
  • Literature Summary
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000036131 Ensembl Gene Model | MGI Sequence Detail 47531 C57BL/6J ±  kb
transcript ENSMUST00000060650 Ensembl | MGI Sequence Detail 2112 Not Applicable  
polypeptide ENSMUSP00000057103 Ensembl | MGI Sequence Detail 703 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 5
    cDNA 3
    Primer pair 2
    Antibodies 1

    Microarray probesets 1
Other
Accession IDs
less
MGI:3643612
References
more
  • Summaries
    All 37
    Developmental Gene Expression 3
    Diseases 1
    Gene Ontology 5
    Phenotypes 15
  • Earliest
    J:155331 Betts-Henderson J, et al., The nystagmus-associated FRMD7 gene regulates neuronal outgrowth and development. Hum Mol Genet. 2010 Jan 15;19(2):342-51
  • Latest
    J:387402 Pitcher MN, et al., Retinal waves shape starburst amacrine cell dendrite development through a direction-selective dendritic computation. Cell Rep. 2026 Jun 1;45(6):117476
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory