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Slc22a14 Gene Detail
Summary
  • Symbol
    Slc22a14
  • Name
    solute carrier family 22 (organic cation transporter), member 14
  • Synonyms
    LOC382113
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685974
    NCBI Gene: 382113
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:119169453-119190430 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 71.33 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    236 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685974
protein coding gene Chr9:119169453-119365553 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035414
protein coding gene Chr9:121893903-122134184 (-)
A/J MGP_AJ_G0035394
protein coding gene Chr9:117386834-117585465 (-)
AKR/J MGP_AKRJ_G0035327
protein coding gene Chr9:120438423-120653674 (-)
BALB/cJ MGP_BALBcJ_G0035390
protein coding gene Chr9:117258000-117462492 (-)
C3H/HeJ MGP_C3HHeJ_G0035098
protein coding gene Chr9:120898144-121117930 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035913
protein coding gene Chr9:125245488-125467588 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032795
protein coding gene Chr9:114578936-114784415 (-)
CAST/EiJ MGP_CASTEiJ_G0034402
protein coding gene Chr9:120862377-121096011 (-)
CBA/J MGP_CBAJ_G0035065
protein coding gene Chr9:129943125-130174093 (-)
DBA/2J MGP_DBA2J_G0035224
protein coding gene Chr9:116824397-117029483 (-)
FVB/NJ MGP_FVBNJ_G0035171
protein coding gene Chr9:115673069-115882949 (-)
LP/J MGP_LPJ_G0035303
protein coding gene Chr9:122241054-122479261 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035212
protein coding gene Chr9:130926292-131147859 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035932
protein coding gene Chr9:120817664-121037383 (-)
PWK/PhJ MGP_PWKPhJ_G0034108
protein coding gene Chr9:117238438-117454935 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033943
protein coding gene Chr9:120934771-121142128 (-)
WSB/EiJ MGP_WSBEiJ_G0034523
protein coding gene Chr9:120705732-120923775 (-)



Homology
more
  • Human Ortholog
    SLC22A14, solute carrier family 22 member 14
  • Vertebrate Orthologs
    7
  • Human Ortholog
    SLC22A14, solute carrier family 22 member 14
    Orthology source: HomoloGene, HGNC
  • Synonyms
    OCTL2, OCTL4, ORCTL4
  • Links
    NCBI Gene ID: 9389
    neXtProt AC: NX_Q9Y267
    UniProt: Q9Y267

  • Chr Location
    3p22.2; chr3:38281662-38318575 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit severe male infertility associated with asthenozoospermia, impaired sperm capacitation, decreased fertilization frequency, abnormal sperm flagellar bending, and abnormal sperm annulus morphology.
Gene Ontology
(GO)
Classifications
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Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 382113 NCBI Gene Model | MGI Sequence Detail 20978 C57BL/6J ±  kb
transcript NM_001037749 RefSeq | MGI Sequence Detail 2200 C57BL/6  
polypeptide NP_001032838 RefSeq | MGI Sequence Detail 629 C57BL/6  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • InterPro Domains
    IPR005828 Major facilitator, sugar transporter-like
    IPR020846 Major facilitator superfamily domain
    IPR036259 MFS transporter superfamily
Molecular
Reagents
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  • All nucleic 7
    cDNA 6
    Primer pair 1

    Microarray probesets 1
References
more
  • Summaries
    All 27
    Phenotypes 14
  • Earliest
    J:12215 Chubb C, Oligotriche and quaking gene mutations. Phenotypic effects on mouse spermatogenesis and testicular steroidogenesis. J Androl. 1992 Jul-Aug;13(4):312-7
  • Latest
    J:277914 Maruyama SY, et al., A critical role of solute carrier 22a14 in sperm motility and male fertility in mice. Sci Rep. 2016 Nov 4;6:36468

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
11/05/2019
MGI 6.14
The Jackson Laboratory