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Brsk1 Gene Detail
Summary
  • Symbol
    Brsk1
  • Name
    BR serine/threonine kinase 1
  • Synonyms
    LOC381979, SAD-B
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685946
    NCBI Gene: 381979
  • Gene Overview
    MyGene.info: BRSK1
Location & Maps
more
  • Genetic Map
    Chromosome 7, 2.71 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    BRSK1, BR serine/threonine kinase 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    BRSK1, BR serine/threonine kinase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    hSAD1
  • Links
    NCBI Gene ID: 84446
    neXtProt AC: NX_Q8TDC3

  • Chr Location
    19q13.4; chr19:55284166-55312562 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    11 phenotypes from multigenic genotypes
    9 phenotype references
Homozygous mutant mice are healthy and fertile.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026253 VEGA Gene Model | MGI Sequence Detail 25394 C57BL/6J ±  kb
transcript OTTMUST00000064928 VEGA | MGI Sequence Detail 2996 Not Applicable  
polypeptide OTTMUSP00000032290 VEGA | MGI Sequence Detail 778 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    107 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 25
    cDNA 25

    Microarray probesets 1
References
more
  • Summaries
    All 32
    Developmental Gene Expression 5
    Gene Ontology 10
    Phenotypes 9
  • Earliest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
  • Latest
    J:215760 Samuel MA, et al., LKB1 and AMPK regulate synaptic remodeling in old age. Nat Neurosci. 2014 Sep;17(9):1190-7

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory