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Lpar5 Gene Detail
Summary
  • Symbol
    Lpar5
  • Name
    lysophosphatidic acid receptor 5
  • Synonyms
    Gpr92, GPR93, LOC381810, LPA5
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685918
    NCBI Gene: 381810
  • Gene Overview
    MyGene.info: LPAR5
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:125067920-125082472 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 59.21 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    55 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685918
protein coding gene Chr6:125067843-125086129 (.)
129S1/SvImJ MGP_129S1SvImJ_G0031284
protein coding gene Chr6:128392851-128407402 (+)
A/J MGP_AJ_G0031254
protein coding gene Chr6:123550885-123565569 (+)
AKR/J MGP_AKRJ_G0031182
protein coding gene Chr6:126926265-126940788 (+)
BALB/cJ MGP_BALBcJ_G0031262
protein coding gene Chr6:123147753-123162285 (+)
C3H/HeJ MGP_C3HHeJ_G0030985
protein coding gene Chr6:126982879-126997406 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031718
protein coding gene Chr6:131775046-131789598 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028868
protein coding gene Chr6:120754745-120769269 (+)
CAST/EiJ MGP_CASTEiJ_G0030366
protein coding gene Chr6:127192356-127206949 (+)
CBA/J MGP_CBAJ_G0030946
protein coding gene Chr6:136825299-136839821 (+)
DBA/2J MGP_DBA2J_G0031102
protein coding gene Chr6:122482774-122497300 (+)
FVB/NJ MGP_FVBNJ_G0031052
protein coding gene Chr6:121389440-121403969 (+)
LP/J MGP_LPJ_G0031182
protein coding gene Chr6:128556479-128571003 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031090
protein coding gene Chr6:140867641-140882173 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031753
protein coding gene Chr6:126817561-126832088 (+)
PWK/PhJ MGP_PWKPhJ_G0030081
protein coding gene Chr6:120722098-120737314 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029910
protein coding gene Chr6:124902071-124920731 (+)
WSB/EiJ MGP_WSBEiJ_G0030451
protein coding gene Chr6:127190045-127204557 (+)



Homology
more
  • Human Ortholog
    LPAR5, lysophosphatidic acid receptor 5
  • Vertebrate Orthologs
    9
  • Human Ortholog
    LPAR5, lysophosphatidic acid receptor 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GPR92, GPR93, KPG_010, LPA5
  • Links
    NCBI Gene ID: 57121
    neXtProt AC: NX_Q9H1C0
    UniProt: Q9H1C0

  • Chr Location
    12p13.31; chr12:6618835-6636131 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit resistance to neuropathic pain and myelin sheath alterations. Mice homozygous for a different targeted allele exhibit decreased nociception sensitivity, decreased anxiety-related response and enhanced coordination and spatial learning.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000067714 Ensembl Gene Model | MGI Sequence Detail 14553 C57BL/6J ±  kb
transcript ENSMUST00000088292 Ensembl | MGI Sequence Detail 1393 Not Applicable  
polypeptide ENSMUSP00000085630 Ensembl | MGI Sequence Detail 384 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • InterPro Domains
    IPR017452 GPCR, rhodopsin-like, 7TM
    IPR000276 G protein-coupled receptor, rhodopsin-like
Molecular
Reagents
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  • All nucleic 9
    cDNA 6
    Primer pair 3

    Microarray probesets 1
References
more
  • Summaries
    All 35
    Developmental Gene Expression 4
    Gene Ontology 3
    Phenotypes 12
  • Earliest
    J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
  • Latest
    J:260680 Tsukahara R, et al., LPA5 signaling is involved in multiple sclerosis-mediated neuropathic pain in the cuprizone mouse model. J Pharmacol Sci. 2018 Feb;136(2):93-96

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory