Lpar5 MGI Mouse Gene Detail - MGI:2685918 - lysophosphatidic acid receptor 5

Symbol

Lpar5
Name

lysophosphatidic acid receptor 5
Synonyms

Gpr92, GPR93, LOC381810, LPA5

Feature Type

protein coding gene
IDs

MGI:2685918
NCBI Gene: 381810
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr6:125044883-125059435 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 59.21 cM
Mapping Data

1 experiment

SNPs within 2kb

55 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2685918	protein coding gene	Chr6:125044808-125063092 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0031284	protein coding gene	Chr6:128392851-128407402 (+)
A/J	MGP_AJ_G0031254	protein coding gene	Chr6:123550885-123565569 (+)
AKR/J	MGP_AKRJ_G0031182	protein coding gene	Chr6:126926265-126940788 (+)
BALB/cJ	MGP_BALBcJ_G0031262	protein coding gene	Chr6:123147753-123162285 (+)
C3H/HeJ	MGP_C3HHeJ_G0030985	protein coding gene	Chr6:126982879-126997406 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0031718	protein coding gene	Chr6:131775046-131789598 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028868	protein coding gene	Chr6:120754745-120769269 (+)
CAST/EiJ	MGP_CASTEiJ_G0030366	protein coding gene	Chr6:127192356-127206949 (+)
CBA/J	MGP_CBAJ_G0030946	protein coding gene	Chr6:136825299-136839821 (+)
DBA/2J	MGP_DBA2J_G0031102	protein coding gene	Chr6:122482774-122497300 (+)
FVB/NJ	MGP_FVBNJ_G0031052	protein coding gene	Chr6:121389440-121403969 (+)
LP/J	MGP_LPJ_G0031182	protein coding gene	Chr6:128556479-128571003 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031090	protein coding gene	Chr6:140867641-140882173 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031753	protein coding gene	Chr6:126817561-126832088 (+)
PWK/PhJ	MGP_PWKPhJ_G0030081	protein coding gene	Chr6:120722098-120737314 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0029910	protein coding gene	Chr6:124902071-124920731 (+)
WSB/EiJ	MGP_WSBEiJ_G0030451	protein coding gene	Chr6:127190045-127204557 (+)

Human Ortholog

LPAR5, lysophosphatidic acid receptor 5

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LPAR5, lysophosphatidic acid receptor 5
Synonyms

GPR92, GPR93, KPG_010, LPA5
Links

HGNC:13307

NCBI Gene ID: 57121

neXtProt AC: NX_Q9H1C0

UniProt: Q9H1C0
Chr Location

12p13.31; chr12:6618835-6635960 (-) GRCh38

MGI Vertebrate Homology

Lpar5 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: LPAR5
Gene Tree

Lpar5

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Phenotype Summary

12 phenotypes from 2 alleles in 2 genetic backgrounds
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

17
Gene trapped

13
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

28 strains or lines available

Mice homozygous for a knock-out allele exhibit resistance to neuropathic pain and myelin sheath alterations. Mice homozygous for a different targeted allele exhibit decreased nociception sensitivity, decreased anxiety-related response and enhanced coordination and spatial learning.

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All GO Annotations

7
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

761
Tissues

36
cDNA Data

7
Literature Summary

6

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase lpar5

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All Sequences

37
RefSeq

6
UniProt

3
CCDS

CCDS51911.1

Ensembl

ENSMUSG00000067714 (Evidence)
NCBI Gene

381810

			Length	Strain/Species	Flank
genomic	ENSMUSG00000067714	Ensembl Gene Model \| MGI Sequence Detail	14553	C57BL/6J	± kb
transcript	ENSMUST00000088292	Ensembl \| MGI Sequence Detail	1393	Not Applicable
polypeptide	ENSMUSP00000085630	Ensembl \| MGI Sequence Detail	372	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000001486 lysophosphatidic acid receptor 5

(term hierarchy)
InterPro Domains

IPR017452 GPCR, rhodopsin-like, 7TM

IPR000276 G protein-coupled receptor, rhodopsin-like

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All nucleic 13

cDNA 7

Primer pair 6

Microarray probesets 1

Summaries

All 45

Developmental Gene Expression 6

Gene Ontology 4

Phenotypes 14
Earliest

J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
Latest

J:331374 de Souza CO, et al., GPR92 activation in islet macrophages controls beta cell function in a diet-induced obesity model. J Clin Invest. 2022 Nov 1;132(21)

TSS for Lpar5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr58895	Chr6:125044636-125044649 (+)	-240 bp
Tssr58896	Chr6:125044651-125044662 (+)	-226 bp
Tssr58897	Chr6:125044876-125044905 (+)	8 bp
Tssr58898	Chr6:125044915-125044918 (+)	34 bp
Tssr58899	Chr6:125048230-125048252 (+)	3,358 bp
Tssr58900	Chr6:125048255-125048268 (+)	3,379 bp
Tssr58901	Chr6:125048289-125048308 (+)	3,416 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/09/2024 MGI 6.23