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Lpar5 Gene Detail
Summary
  • Symbol
    Lpar5
  • Name
    lysophosphatidic acid receptor 5
  • Synonyms
    Gpr92, GPR93, LOC381810, LPA5
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685918
    NCBI Gene: 381810
  • Gene Overview
    MyGene.info: LPAR5
Location & Maps
more
  • Sequence Map
    Chr6:125067920-125082472 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      14553 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 59.21 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    LPAR5, lysophosphatidic acid receptor 5
  • Vertebrate Orthologs
    9
  • Human Ortholog
    LPAR5, lysophosphatidic acid receptor 5
    Orthology source: HGNC, HomoloGene
  • Synonyms
    GPR92, GPR93, KPG_010, LPA5
  • Links
    NCBI Gene ID: 57121
    neXtProt AC: NX_Q9H1C0

  • Chr Location
    12p13.31; chr12:6618835-6636131 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    19
  • Gene trapped
    15
  • Targeted
    4
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit resistance to neuropathic pain and myelin sheath alterations. Mice homozygous for a different targeted allele exhibit decreased nociception sensitivity, decreased anxiety-related response and enhanced coordination and spatial learning.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022555 VEGA Gene Model | MGI Sequence Detail 14553 C57BL/6J ±  kb
transcript OTTMUST00000054027 VEGA | MGI Sequence Detail 1393 Not Applicable  
polypeptide OTTMUSP00000025730 VEGA | MGI Sequence Detail 384 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    55 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000001486 lysophosphatidic acid receptor 5
  • InterPro Domains
    IPR017452 GPCR, rhodopsin-like, 7TM
    IPR000276 G protein-coupled receptor, rhodopsin-like
Molecular
Reagents
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  • All nucleic 8
    cDNA 5
    Primer pair 3

    Microarray probesets 1
References
more
  • Summaries
    All 33
    Developmental Gene Expression 4
    Gene Ontology 3
    Phenotypes 10
  • Earliest
    J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
  • Latest
    J:230717 Takeda A, et al., Fibroblastic reticular cell-derived lysophosphatidic acid regulates confined intranodal T-cell motility. Elife. 2016;5:e10561

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory