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Pdp1
Gene Detail
Symbol

Name
ID
Pdp1
pyruvate dehyrogenase phosphatase catalytic subunit 1
MGI:2685870
Synonyms
LOC381511, Ppm2c
Feature Type
protein coding gene
Genetic Map
Chromosome 4
5.48 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr4:11958184-11966452 bp, - strand
From VEGA annotation of GRCm38

  8269 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31928  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PDP1
Gene Tree: Pdp1

Human
homologs
PDP1, pyruvate dehyrogenase phosphatase catalytic subunit 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 54704
neXtProt AC: NX_Q9P0J1

Human Synonyms: PDH, PDP, PDPC, PPM2C

Human Chr (Location): 8q22.1; chr8:93916855-93926068 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human PDP1

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Spontaneous(1) Targeted(2) Transgenic(3)
Genomic Mutations involving Pdp1 (1)
Mutations Annotated to Human Diseases (1)   
Interactions
Pdp1 interacts with 339 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process peptidyl-threonine dephosphorylation, protein dephosphorylation
Component mitochondrion
Function calcium ion binding, catalytic activity, ...
External Resources: FuncBase
Expression
cDNA source data(24)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase pdp1 ; ZFIN pdp1    NEW 
Molecular
reagents
All nucleic(24) cDNA(24)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000004573 (Evidence)
Ensembl Gene Model ENSMUSG00000049225 (Evidence)
Entrez Gene 381511 (Evidence)
UniGene 331489
DFCI TC1584272, TC1612446, TC1631934, TC1634895, TC1703395, TC1749711
DoTS DT.101360511, DT.110814405, DT.481000, DT.55179170, DT.97365014
NIA Mouse Gene Index U041412
EC 3.1.3.43
Consensus CDS Project CCDS38694.1, CCDS51121.1, CCDS71345.1
International Mouse Phenotyping Consortium Status Pdp1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000004573 VEGA Gene Model | MGI Sequence Detail 8269 C57BL/6J ±  kb
transcript OTTMUST00000010346 VEGA | MGI Sequence Detail 2635 Not Applicable 
polypeptide OTTMUSP00000004911 VEGA | MGI Sequence Detail 597 Not Applicable 

For the selected sequences
All sequences(71) RefSeq(10) UniProt(6)
Polymorphisms
SNPs within 2kb(21 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000222 PPM-type phosphatase, divalent cation binding
InterPro IPR001932 PPM-type phosphatase domain
InterPro IPR015655 Protein phosphatase 2C
Protein Ontology PR:000012513 [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial
References
(Earliest) J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(28)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory