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Pdp1 Gene Detail
Summary
  • Symbol
    Pdp1
  • Name
    pyruvate dehyrogenase phosphatase catalytic subunit 1
  • Synonyms
    LOC381511, Ppm2c
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685870
    NCBI Gene: 381511
Location & Maps
more
  • Sequence Map
    Chr4:11958184-11966452 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      8269 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 5.48 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    PDP1, pyruvate dehyrogenase phosphatase catalytic subunit 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PDP1, pyruvate dehyrogenase phosphatase catalytic subunit 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    PDH, PDP, PDPC, PPM2A, PPM2C
  • Links
    NCBI Gene ID: 54704
    neXtProt AC: NX_Q9P0J1

  • Chr Location
    8q22.1; chr8:93916855-93926068 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 31928
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: PDP1
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human PDP1 associations

Human Disease Mouse Models
       Pyruvate Dehydrogenase Phosphatase Deficiency; PDHPD   OMIM: 608782
Click on a disease name to see all genes associated with that disease.

  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotype references
  • All Mutations and Alleles
    9
  • Spontaneous
    1
  • Targeted
    2
  • Transgenic
    6
  • Genomic Mutations
    1 involving Pdp1
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000004573 VEGA Gene Model | MGI Sequence Detail 8269 C57BL/6J ±  kb
transcript OTTMUST00000010346 VEGA | MGI Sequence Detail 2635 Not Applicable  
polypeptide OTTMUSP00000004911 VEGA | MGI Sequence Detail 597 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    21 from dbSNP Build 142
Protein
Information
less
  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000012513 [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial
  • EC
  • InterPro Domains
    IPR000222 PPM-type phosphatase, divalent cation binding
    IPR001932 PPM-type phosphatase domain
    IPR015655 Protein phosphatase 2C family
Molecular
Reagents
less
  • All nucleic 24
    cDNA 24

    Microarray probesets 5
References
more
  • Summaries
    All 25
    Diseases 3
    Gene Ontology 5
    Phenotypes 5
  • Earliest
    J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory