Pdp1
Gene Detail

Symbol Name ID

Pdp1 pyruvate dehyrogenase phosphatase catalytic subunit 1 MGI:2685870

Synonyms

LOC381511, Ppm2c

Feature Type

protein coding gene

Genetic Map

Chromosome 4

5.48 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr4:11958184-11966452 bp, - strand From VEGA annotation of GRCm38   8269 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:31928  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Pdp1

Human homologs

Human Homolog		PDP1, pyruvate dehyrogenase phosphatase catalytic subunit 1
NCBI Gene ID		54704
neXtProt AC		NX_Q9P0J1
Human Synonyms		PDH, PDP, PDPC, PPM2C
Human Chr (Location)		8q22.1; chr8:94929083-94938296 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human PDP1

Alleles and phenotypes

All alleles(2) : Targeted(2)

Gene Ontology (GO) classifications

All GO classifications: (18 annotations)

Process	dephosphorylation, metabolic process, ...
Component	mitochondrion
Function	calcium ion binding, catalytic activity, ...

External Resources: FuncBase

Expression

cDNA source data(24)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(24) cDNA(24)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000004573 (Evidence)
Ensembl Gene Model	ENSMUSG00000049225 (Evidence)
Entrez Gene	381511 (Evidence)
UniGene	331489
DFCI	TC1584272, TC1612446, TC1631934, TC1634895, TC1703395, TC1749711
DoTS	DT.101360511, DT.481000, DT.55179170, DT.97365014
NIA Mouse Gene Index	U041412
EC	3.1.3.43
Consensus CDS Project	CCDS38694.1, CCDS51121.1
International Mouse Knockout Project Status	Pdp1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000004573	VEGA Gene Model | MGI Sequence Detail	8269	C57BL/6J
transcript	OTTMUST00000010346	VEGA | MGI Sequence Detail	2635	Not Applicable
polypeptide	OTTMUSP00000004911	VEGA | MGI Sequence Detail	597	Not Applicable

All sequences(63) RefSeq(6) UniProt(6)

Polymorphisms

SNPs(3 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR015655	Protein phosphatase 2C
InterPro	IPR000222	Protein phosphatase 2C, manganese/magnesium aspartate binding site
InterPro	IPR001932	Protein phosphatase 2C (PP2C)-like
Protein Ontology	PR:000012513	[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial

References

(Earliest) J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(30)