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Pdp1
Gene Detail
Symbol

Name
ID
Pdp1
pyruvate dehyrogenase phosphatase catalytic subunit 1
MGI:2685870
Synonyms
LOC381511, Ppm2c
Feature Type
protein coding gene
Genetic Map
Chromosome 4
5.48 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr4:11958184-11966452 bp, - strand
From VEGA annotation of GRCm38

  8269 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31928  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Pdp1

Human
homologs
Human Homolog PDP1, pyruvate dehyrogenase phosphatase catalytic subunit 1
NCBI Gene ID 54704
neXtProt AC  NX_Q9P0J1
Human Synonyms  PDH, PDP, PDPC, PPM2C
Human Chr (Location)  8q22.1; chr8:93916855-93926068 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human PDP1
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Spontaneous(1) Targeted(2)
Genomic Mutations involving Pdp1 (1)
Alleles Annotated to Human Diseases(1)   
Interactions
Pdp1 interacts with 340 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process peptidyl-threonine dephosphorylation, protein dephosphorylation
Component mitochondrion
Function calcium ion binding, catalytic activity, ...
External Resources: FuncBase
Expression
cDNA source data(24)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(24) cDNA(24)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000004573 (Evidence)
Ensembl Gene ModelENSMUSG00000049225 (Evidence)
Entrez Gene381511 (Evidence)
UniGene331489
DFCITC1584272, TC1612446, TC1631934, TC1634895, TC1703395, TC1749711
DoTSDT.101360511, DT.110814405, DT.481000, DT.55179170, DT.97365014
NIA Mouse Gene IndexU041412
EC3.1.3.43
Consensus CDS ProjectCCDS38694.1, CCDS51121.1, CCDS71345.1
International Mouse Knockout Project StatusPdp1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000004573 VEGA Gene Model | MGI Sequence Detail 8269 C57BL/6J ±  kb
transcript OTTMUST00000010346 VEGA | MGI Sequence Detail 2635 Not Applicable 
polypeptide OTTMUSP00000004911 VEGA | MGI Sequence Detail 597 Not Applicable 

For the selected sequences
All sequences(71) RefSeq(10) UniProt(6)
Polymorphisms
SNPs within 2kb(21 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015655 Protein phosphatase 2C
InterPro IPR000222 Protein phosphatase 2C, manganese/magnesium aspartate binding site
InterPro IPR001932 Protein phosphatase 2C (PP2C)-like
Protein Ontology PR:000012513 [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial
References
(Earliest) J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(30)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory