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Zfp408 Gene Detail
Summary
  • Symbol
    Zfp408
  • Name
    zinc finger protein 408
  • Synonyms
    LOC381410
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685857
    NCBI Gene: 381410
  • Gene Overview
    MyGene.info: ZNF408
Location & Maps
more
  • Sequence Map
    Chr2:91643669-91649791 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6123 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 50.63 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    ZNF408, zinc finger protein 408
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ZNF408, zinc finger protein 408
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EVR6, RP72
  • Links
    NCBI Gene ID: 79797
    neXtProt AC: NX_Q9H9D4

  • Chr Location
    11p11.2; chr11:46700767-46705916 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with human ZNF408 associations

Human Disease Mouse Models
       Exudative Vitreoretinopathy 6; EVR6   OMIM: 616468
Retinitis Pigmentosa 72; RP72   OMIM: 616469
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotype references
  • All Mutations and Alleles
    17
  • Chemically induced (other)
    1
  • Gene trapped
    8
  • Radiation induced
    1
  • Targeted
    7
  • Genomic Mutations
    4 involving Zfp408
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014301 VEGA Gene Model | MGI Sequence Detail 6123 C57BL/6J ±  kb
transcript OTTMUST00000033706 VEGA | MGI Sequence Detail 3469 Not Applicable  
polypeptide OTTMUSP00000015107 VEGA | MGI Sequence Detail 710 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    52 from dbSNP Build 142
Protein
Information
less
  • UniProt
    5 Sequences
  • InterPro Domains
    IPR007087 Zinc finger, C2H2
    IPR015880 Zinc finger, C2H2-like
    IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Molecular
Reagents
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  • All nucleic 21
    cDNA 20
    Primer pair 1

    Microarray probesets 1
References
more
  • Summaries
    All 23
    Gene Ontology 1
    Phenotypes 13
  • Earliest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory