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Nsl1 Gene Detail
Summary
  • Symbol
    Nsl1
  • Name
    NSL1, MIS12 kinetochore complex component
  • Synonyms
    4833432M17Rik, LOC381318
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685830
    NCBI Gene: 381318
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:190794710-190816755 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 96.28 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    708 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685830
 protein coding gene Chr1:190794710-190818671 (+)
129S1/SvImJ ENSMUSG00200003511
 protein coding gene Chr1:188574870-188599055 (+)
A/J ENSMUSG00195008008
 protein coding gene Chr1:188154975-188178442 (+)
AKR/J ENSMUSG00220004502
 protein coding gene Chr1:187398828-187422297 (+)
BALB/cJ ENSMUSG00180016285
 protein coding gene Chr1:188220426-188243894 (+)
C3H/HeJ ENSMUSG00175022000
 protein coding gene Chr1:188408422-188431889 (+)
C57BL/6NJ ENSMUSG00215012132
 protein coding gene Chr1:187627986-187651445 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015045
 protein coding gene Chr1:180867691-180892400 (+)
CAST/EiJ ENSTCUG00005002020
 protein coding gene Chr1:186189974-186213748 (+)
CBA/J ENSMUSG00210003333
 protein coding gene Chr1:188069944-188094130 (+)
DBA/2J ENSMUSG00185010478
 protein coding gene Chr1:192683196-192707381 (+)
FVB/NJ ENSMUSG00205003961
 protein coding gene Chr1:187066459-187089925 (+)
JF1/MsJ ENSUMUG00000005640
 protein coding gene Chr1:191667081-191691518 (+)
LP/J ENSMUSG00230021275
 protein coding gene Chr1:192219318-192242785 (+)
NOD/ShiLtJ ENSMUSG00190027346
 protein coding gene Chr1:188053467-188077650 (+)
NZO/HlLtJ ENSMUSG00225015352
 protein coding gene Chr1:195980123-196004308 (+)
PWK/PhJ ENSLUMG00010006243
 protein coding gene Chr1:186902171-186926358 (+)
SPRET/EiJ ENSMSPG00010023038
 protein coding gene Chr1:190441043-190462024 (+)
WSB/EiJ ENSIUOG00005004367
 protein coding gene Chr1:187404184-187427657 (+)



Homology
more
  • Human Ortholog
    NSL1, NSL1 component of MIS12 kinetochore complex
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NSL1, NSL1 component of MIS12 kinetochore complex
  • Synonyms
    C1orf48, DC8, MIS14
  • Links
    NCBI Gene ID: 25936
    UniProt: Q96IY1

  • Chr Location
    1q32.3; chr1:212726153-212791783 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    1 images
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show complete embryonic lethality prior to organogenesis. In vitro outgrowth assays show that embryos fail to hatch from the zona pellucida and die after 3 days in culture, never forming blastocysts.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    7
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    26
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 381318 NCBI Gene Model | MGI Sequence Detail 22046 C57BL/6J ±  kb
    transcript NM_198654 RefSeq | MGI Sequence Detail 2973 Not Specified  
    polypeptide Q8K305 UniProt | EBI | MGI Sequence Detail 281 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 26
      cDNA 26

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2138254, MGI:2684951
    References
    more
    • Summaries
      All 39
      Gene Ontology 7
      Phenotypes 10
    • Earliest
      J:85162 Hansen J, et al., A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9918-22
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory