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Hecw2 Gene Detail
Summary
  • Symbol
    Hecw2
  • Name
    HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
  • Synonyms
    A730039N16Rik, D030049F17Rik, mKIAA1301, Nedl2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685817
    NCBI Gene: 329152
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:53806872-54195034 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 26.99 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2696 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685817
protein coding gene Chr1:53806872-54195168 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016023
protein coding gene Chr1:53462909-53876182 (-)
A/J MGP_AJ_G0016006
protein coding gene Chr1:51609736-51996133 (-)
AKR/J MGP_AKRJ_G0015962
protein coding gene Chr1:52998116-53401965 (-)
BALB/cJ MGP_BALBcJ_G0015961
protein coding gene Chr1:51656479-52047491 (-)
C3H/HeJ MGP_C3HHeJ_G0015793
protein coding gene Chr1:53239164-53637379 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016414
protein coding gene Chr1:55710298-56115438 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014136
protein coding gene Chr1:47745501-48125469 (-)
CAST/EiJ MGP_CASTEiJ_G0015375
protein coding gene Chr1:52510275-52928083 (-)
CBA/J MGP_CBAJ_G0015765
protein coding gene Chr1:57262665-57675507 (-)
DBA/2J MGP_DBA2J_G0015866
protein coding gene Chr1:51052375-51445598 (-)
FVB/NJ MGP_FVBNJ_G0015868
protein coding gene Chr1:50400187-50783737 (-)
LP/J MGP_LPJ_G0015938
protein coding gene Chr1:54294527-54699253 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0015888
protein coding gene Chr1:60386045-60797847 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016461
protein coding gene Chr1:52978149-53388142 (-)
PWK/PhJ MGP_PWKPhJ_G0015161
protein coding gene Chr1:50403586-50784184 (-)
SPRET/EiJ MGP_SPRETEiJ_G0014942
protein coding gene Chr1:52546542-52937424 (-)
WSB/EiJ MGP_WSBEiJ_G0015438
protein coding gene Chr1:52662908-53062610 (-)



Homology
more
  • Human Ortholog
    HECW2, HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    HECW2, HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    NDHSAL, NEDL2
  • Links
    NCBI Gene ID: 57520
    neXtProt AC: NX_Q9P2P5
    UniProt: Q9P2P5

  • Chr Location
    2q32.3; chr2:196194382-196593692 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 329152 NCBI Gene Model | MGI Sequence Detail 388163 C57BL/6J ±  kb
transcript NM_001001883 RefSeq | MGI Sequence Detail 11179 Not Specified  
polypeptide Q6I6G8 UniProt | EBI | MGI Sequence Detail 1578 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 8
    cDNA 8

    Microarray probesets 2
Other
Accession IDs
less
MGI:2442222
References
more
  • Summaries
    All 34
    Gene Ontology 5
    Phenotypes 11
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory